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IQSEC1 human	MWCLHCNSERTQSLL----ELELDSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLySGPPGQQ-QRTRRPKLQHstsILRKQAEEEAIKRSRsLsEsYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNkNFERLRSSMSENRMsRRIVLSNMRMQFsFEGPEKVHSSYFEGkQVSVtNDGSQLGALVsPECGDLSEP--TTLksPAPSSDFADAITELEDAFSRQVkSLAEsIDDALNCRsLHtEEAPALDAARARDTEPQTALHGM-DHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDyWALAHKEDKADTDTSCRStPsLERQEQRLRVEHLPLLTIEPPsDSSVDLSDRSERGsLKRQSAYERsLGGQQGsPKHGPHsGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDySDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSkQTYHKEARNsWDsPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIkNLrGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKkFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPsMSQCSsLKKEsGNGtLSRACLDDsyAsGEGLkRSALsssLRDLSEAGKRGRRssAGsLESNVEFQPFEPLQPS------VLCS-------------------------------------------------------------------------------------------------------------------------------------------------------------------
IQSEC1 iso2 human	-------------------------------------------------------------------------------------------------------------------------------MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEP--TTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGM-DHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPS------VLCS-------------------------------------------------------------------------------------------------------------------------------------------------------------------
IQSEC1 iso3 human	--------------M----ACRRRyFVEGEAPSSETGTSLDSPSAyPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQ-QRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEP--TTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGM-DHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPQPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQLRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSsAGsLESNVEGsIISsPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSVAGHHLGPPEGLPQAAMHGHHTQYCHMQNPPP-YHHHHHHHPPQHIQHAHQYHHGPHGGHPAYGAHAHGHPPLPSAHV---GHTVHHHGQPPAPPPPTSSKAKPSGISTIV
IQSEC1 mouse	MWCLHCNSERTQSLL----ELELDSGVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGP-GPQ-QRTRRPRLQHstsVLRKQAEEEAIKRSRsLsESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSsMsENRMSrRIVLSNMRMQFsFEGPEKVHSSYFEGKQVSVTNDGsQLGALVPSECGDLSDP--A-LKSPAPSSDFADAITELEDAFSRQVKsLAEsIDDALNCRsLHSEEVPASDTARARDTEPKPGLHGM-DHRKLDEMTASYSDVTLYIDEEELsPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWALAHKEDKADtDTSCRstPsLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSsLKRQSAYERSLGGQQGsPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQsKSESDYsDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEtRNsWDsPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGsLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNsVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMsQCSSLKKESGNGtLSRACLDDSYASGEGLKRSALsssLRDLsEAGkRGRRSSAGSLESNVEFQPFQPPQPPVL------CS-------------------------------------------------------------------------------------------------------------------------------------------------------------------
IQSEC1 iso3 mouse	------------------MACRRRYFVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGP-GPQ-QRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFsFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDP--A-LKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGM-DHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDsPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRssAGsLEsNVEGsIIssPHMRRRATSTRECPSRPPQPVPNSSSLLGSLFGsRRGKPPPQAHPPSAPPPAPPHA-------------HHPGPS----EGPLHGHHAQYCHAQQNPPPYHHHHHYHPPPHLQHTHQYHHGPHGGHPPYGAHAHSHPPLPTAHPGHAGHSAHHHGQPPAPPPPTSSKAKPSGIStVV
IQSEC1 rat	---MACRRRYLSSLETGSSLSTDRYSVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGP-GPQ-QRTRRPRLQHSTSVLRKQAEEEAIKRSRsLsEsyELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMsENRMSRRIVLSNMRMQFsFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDP--A-LKsPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGM-DHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDyWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSSLKRQSAYERSLGGQQGsPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNsWDsPAFSNDVIRKRHYRIGLNLFNKKPEkGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQkVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIyERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMsQCssLKKESGNGTLSRACLDDsyAsGEGLKRSALSSsLRDLSEAGKRGRRSSAGSLESNVEFQPFQPSQPPVL------CS-------------------------------------------------------------------------------------------------------------------------------------------------------------------
IQSEC1 cow	MWCLHCNSERTQSLL----ELELDSGVEGEAPSSEPGTSLDSPSAYHQGPLAPGSGLSPEPYEHAPSGAYGLYAGPPGQQQQRARRPRLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSEKRLSRRIVLSNMRVQLsFEGPEKAHSSFFEGKQVSVTDGDSPLGSLGPAECGDLGPPPPPALQAPAPASDFADAITELEDAFSRQVKSLAESIDDALNCRSLHAVEGAP-----TPAAEPSSGLHGAAEQRRLDEMTASYSDVTLYIDEDELSPPLPAAQAGCRPSSGESDLRLRAGAAAQDYWALAHKDDKGDTDTSCRSTPSLE---PRARVEHLPLLTIEPPSDSSADLSDRSDRSSLKRQSAYERGLGGPQGSPKHGPH-GPPRGLPREEPELRARPPRPLDAHLAINGSANRQSKSESDYSDGDNDSLNSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDVIRKRLYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRELLVGIYERIRRRELKTSEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIEAELEKQKGVVRPSMSQCPSLKKEPGGGTLSRACLDDSYAGGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRDCPSRPHQATPNSSSLLGSLFGSKRGKPPPQAHLPPAPAPPRPA------------TGHPQGPVEGPLAGPVHGHHGQYCCLQQNPPPYHHHHHHHPPPHIQHAHQHHHGPHGGHPAYGAHAHGHPPLPAG---HAGHAAHHHGQPPAPPLPTSSKAKPSGISTIV
	...............    :......::::::::::::::::::::::::::::::::::::::::::::::::::.:.: ::::::::::::::::::::::::::::::::::::::::::::::*****************************************:*:**********:*:*******:***:*********:::*:**:*:::*****::*  :.*::***:***********************************::*:::.::::::::**:::***: ::*:*****************:*******::***:****:*******:*:**:********:**:*************:.::*:*****************::*****:*:**********:***:*********.*:*::*********::*****::*************************:***********************************:*****************:***************:*********************************************************:***********************************:********:************************************:***************:*:*******:*****:************************:*****************************************************************************************:******************************:************:****************:*****:*:*************:************************************::::.::::.........*:.....  ..................................              .. ..      .. .... .... ..... ......................................... .     .. ...........................
Consensus	---LHCNSERTQSLL----ELELRSGVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGP-GQQ-QRTRRPRLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPPECGDLSDP--ATLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEAPALDAARARDTEPQPGLHGM-DHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAQDYWALAHKEDKADTDTSCRSTPSLERQEPRLRVEHLPLLTIEPPSDSSVDLSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFSPPQPRRR----RECS-------------------------------------------------------------------------------------------------------------------------------------------------------------------