	( 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 )
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SMC4 human	MPRkGTQPSTARRREEGPPPPsPDGAs sDAEPEPPsGRtEsPAtAAEtAsEELDNRSLEEILNSIPPPPPPAMTNEAGAPRLMItHIVNQNFk K93-m1 K93-ub SYAGEkILGPFHkRFsCIIGPNGSGkSNVIDSMLFVFGYRAQKIRSKkLsVLIHNsDEHkDIQSCTVEVHFQKIIDkEGDDyEVIPNSNFYVSRtACRDNTSVyHIsGk kKTFk K207-ub K207-sc DVGNLLrSHGIDLDHNRFLILQGEVEQIAMMKPkGQTEHDEGMLEYLEDIIGCGRLNEPIk K268-ac K268-ub VLCRRVEILNEHrGEKLNRVKMVEkEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQkRIAEMETQkEkIHEDtk K349-ac K349-ub EINEk K354-ac K354-ub sNILSNEMk K363-ac K363-ub AKNKDVKDTEKKLNKITk K381-ac K381-ub FIEENKEkFTQLDLEDVQVREKLKHATSKAKkLEk K416-ac K416-ub QLQKDKEKVEEFKSIPAkSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFsKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTkAKEALIAAsEtLKERKAAIRDIEGkLPQTEQELKEKEKELQkLTQEETNFk K573-ac K573-ub sLVHDLFQkVEEAk s sLAMNRsRGk K598-ac K598-ub VLDAIIQEk K607-ac K607-ub kSGRIPGIyGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAkKMtEIQtPENTPRLFDLVkVKDEKIRQAFyFALRDTLVADNLDQATRVAYQKDRRWRVVtLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKkAMQIQEQkVQLEERVVKLRHSEREMRNTLEkFtASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQkLLEENVSAFkTEYDAVAEkAGKVEAEVKRLHNTIVEINNHkLKAQQDKLDKINKQLDECASAITkAQVAIkTADRNLQkAQDSVLRTEKEIKDTEkEVDDLTAELkSLEDkAAEVVkNTNAAEEsLPEIQkEHRNLLQELkVIQENEHALQk K1009-ac K1009-ub DALsIkLKLEQIDGHIAEHNsk K1031-ac K1031-ub IKYWHk K1037-ac K1037-ub EISkIsLHPIEDNPIEEIsVLsPEDLEAIkNPDSITNQIALLEARCHEMkPNLGAIAEYk k kEELYLQRVAELDkITyERDSFRQAYEDLRKQRLNEFMAGFYIITNkLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKkIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIy kTYNITkSVAVNPkEIASkGLC
SMC4 iso2 human	MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEEILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAA----------------------------------------------------------EISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVAVNPKEIASKGLC
SMC4 mouse	MRRKGTKPSTACHQEEGPP-PSQDGAHsDEEMEQPAGEAESAAP-AKPPGEELDNRSLEEILNSIPPPPPPAMASEAGAPRLMITHIVNQNFKSYAGEKVLGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVLPNSNFYVSRTAYRDSTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEMFKKKNHICQYYIYDLQNRIAEITTQKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDVEkKLNkVTKFIEQNKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSVPAKSKTVINETTTRNNSLEKEREKEEKKLKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRHNTAVSQLSKAKEALITASETLKERKAAIKDINTKLPQTQQELKEKEKELQKLTQEEINLKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHNIGIATFIGLDKMtVWAKKMSKIQTPENTPRLFDLVKVKNEEIRQAFYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMSGGGSKVMRGRMGSSVIDEISVEEVNKMESQLERHSKQAMQIQEQKVQHEEAVVKLRHSERDMRNTLEKFAASIQGLSEQEEYLCVQIKELEANVLTTAPDRKQQKLLEENVSVFKKEYDAVAEKAGKVEAEIKRLHNTIIDINNRKLKAQQNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRTEKEIKDTEKEINDLKTELKNIEDKAEEVINNTKTAETSLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHISEHNSKIKYWQKEISKIKLHPVEDNPVETVAVLSQEELEAIKNPESITNEIALLEAQCREMKPNLGAIAEYKKKEDLYLQRVAELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKkIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNSTKSVAVNPKQIASKGLC
SMC4 rat	MRRKGTKPSTACHQEEGPP-PSEDGALsEGEKEQPDCEVDSAAA-AETPGEELDSRSLEEILNSIPPPPPPAMASEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHTDIQSCTVEVHFQKIIDKEGDDYDVLPNSNFYVSRTAYRDNTSVYHISGKKRTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFKKKNHICQYYIYDLQNRIAEMKTQKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDIEKKLNKVTKFIEQNKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSIPAKSKNVINETTTRNNSLEKEREKEEKKLKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRHNTAVSQLSKAKDALITASETLKERKAAIKDINTKLPQAQQELKEKEKELQKLTQEEINLKSLVHDLFQKVEEAKSSLATNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHNIGVATFIGLDKMAVWAQKMNKIQTPENTPRLFDLVKVKNEEIRQAFYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMTGGGSKVMRGRMGSSVVDEISVEEVNKMECQLERHSKQAAQVQEQKVQHEEAIVKLKQSEREMRNTLEKFTASIQGLSEQEEYLCVQIKELEANVLTTAPDKKQQKLLEENVNVFKKEYDAVAEKAGKVEAEIKRLHDTIIDINNRKLKAQQNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRTEkEIKDTEKEINDLKTELKNIEDNAEEVIKNTKDAEKSLPEIQKEHRALLQELKVIQDNEHALQKDALSIKLKLEQIDGHISEHNSKIKYWQKEISKIKLHPVEDNPVETVSVLSQEDLEAIKSPDSITNQIALLEAQCREMKPNLGAIAEYKKKEELYLQRVGELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVAVNPKEIASKGLC
	:*::::*..**.::.::::::::.::::**:**************::********************:************************************************:*******************::*********::********:***********************************************************************************************************::**:**::**:.*********::*****::.***:*:**************************************::**:::*****::**********************::***:******:****************:::********:::**::**************::*****************:**********************************:**************:*****:::******::.:***************::*************:*******:****************:***:**::::****::::*:::***:::*:::*****:*::****::******:*::******:::*************::::*:**::***********************:**:********::::*:::::::::.::::::::::::::::::::.:::::::::::::::::::::::::::::::::.:***::**::::**::****::**:***::**************:**:**::******************:*****************************************************************************************************************************:*****:*****
Consensus	MRRKGTQPSTARRREEGPPPPSPDGASSDAEPEQPSGRTESAATAAETAGEELDNRSLEEILNSIPPPPPPAMANEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHICQYYIYDLQNRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKAVKDTEKKLNKITKFIEQNKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSIPAKSNNIINETTTRNNALEKEREKEEKKLKEVMDSLKQETQGLQKEKEIREKELMGFNKSVNEARSKMDVAQSELDIYLSRHNTAVSQLSKAKEALIAASETLKERKAAIRDINGKLPQTQQELKEKEKELQKLTQEEINLKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKNEEIRQAFYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMTGGGSKVMRGRMGSSLVDEISEEEVNKMESQLQRDSKQAMQIQEQKVQHEEAVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQIKELEANVLATAPDKKQQKLLEENVSAFKKEYDAVAEKAGKVEAEIKRLHNTIIDINNRKLKAQQNKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVCRTEKEIKDTEKEINDLKAELKNIEDKAAEVIKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHISEHNSKIKYWQKEISKIKLHPIEDNPIEEISVLSQEDLEAIKNPDSITNQIALLEARCREMKPNLGAIAEYKKKEELYLQRVAELDKITSERDNFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSVAVNPKEIASKGLC

Multiple Sequence Alignment:
SMC4	Download MSA