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USP42 human	MTIVDKASESSDPSAYQNQPGSSEAVSPGDMDAGSASWGAVSSLNDVSNHTLSLGPVPGAVVySSSSVPDKsKPsPQKDQALGDGIAPPQkVLFPSEKICLKWQQTHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRHTQATTLVCQIFGGyLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVkPEQLDGENsyKCSKCKKMVPASKRFTIHRSSNVLTLSLKRFANFTGGkIAKDVKYPEYLDIRPYMSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLSQQAYVLFYIRSHDVKNGGELtHPtHsPGQssPRPVIsQRVVTNKQAAPGFIGPQLPSHMIKNPPHLNGTGPLKDTPSsSMSsPNGNSSVNRAsPVNASASVQNWSVNRSSVIPEHPKKQKITISIHNKLPVRQCQSQ--PNLHSNSLENPTKPVPSSTITNSA-VQSTSNASTMSVSSKVTKPIPRSESCSQPVMNGKSKLNSSVLVPyGAEssEDsDEEsKGLGKENGIGTIVSSHSPGQD---AEDEEATPHELQEPMTLNGANSADSDSDPKENGLAPDGASCQGQPALHSENPFAKANGLPGKLMPAPLLSLPEDKILETFRLSNKLKGSTDEMSAPGAERGPPEDRDAEPQPGsPAAEsLEEPdAAAG-LSSTKKAPPPRDPGtPATKEGAW------EAMAVAPEEPP-PSAGEDIVGDTAPPDLCDPGSLTGDAsPLsQDAKGMIAEGPRDSALAEAPEGLsPAPPARSEEPCEQPLLVHPSGDHARDAQDPSQSLGAPEAAERPPAPVLDMAPAGHPEGDAEPsPGERV-EDAAAPKAPGPsPAKEKIGSLRKVDRGHyRSRRERSSSGEPARESRSKTEGHRHRRRRTCPRERDRQDRHAPE------HHPGHGDRLsPGERRSLGRCSHHHSRHRsGVELDWVRHHYTEGERGWGREKFYPDRPRWDRCRYYHDRyAL--Y----AARDWKPFHGGREHERAGLHERPHKDHNRGRRGCEPARER-ERHRPssPRAGAPHALAPHPDRFsHDRTALVAGDNCNLsDRFHEHENGKSRKRRHDsVENsDSHVEKKARRsEQkDPLEEPk K1191-ac K1191-ub AkkHKKSKKKKKSKDKHRDRDsRHQQDsDLsAACsDADLHRHKKKKKKKKRHSRKsEDFVKDSELHLPRVTsLETVAQFRRAQGGFPLsGGPPLEGVGPFREKTKHLRMESRDDRCRLFEYGQGKRRYLELGR
USP42 iso2 human	MTIVDKASESSDPSAYQNQPGSSEAVSPGDMDAGSASWGAVSSLNDVSNHTLSLGPVPGAVVYSSSSVPDKSKPSPQKDQALGDGIAPPQKVLFPSEKICLKWQQTHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRFANFTGGKIAKDVKYPEYLDIRPYMSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLSQQAYVLFYIRSHDVKNGGELTHPTHSPGQSSPRPVISQRVVTNKQAAPGFIGPQLPSHMIKNPPHLNGTGPLKDTPSSSMSSPNGNSSVNRASPVNASASVQNWSVNRSSVIPEHPKKQKITISIHNKLPVRQCQSQ--PNLHSNSLENPTKPVPSSTITNSA-VQSTSNASTMSVSSKVTKPIPRSESCSQPVMNGKSKLNSSVLVPYGAESSEDSDEESKGLGKENGIGTIVSSHSPGQD---AEDEEATPHELQEPMTLNGANSADSDSDPKENGLAPDGASCQGQPALHSENPFAKANGLPGKLMPAPLLSLPEDKILETFRLSNKLKGSTDEMSAPGAERGPPEDRDAEPQPGSPAAESLEEPDAAAG-LSSTKKAPPPRDPGTPATKEGAW------EAMAVAPEEPP-PSAGEDIVGDTAPPDLCDPGSLTGDASPLSQDAKGMIAEGPRDSALAEAPEGLSPAPPARSEEPCEQPLLVHPSGDHARDAQDPSQSLGAPEAAERPPAPVLDMAPAGHPEGDAEPSPGERV-EDAAAPKAPGPSPAKEKIGSLRKVDRGHYRSRRERSSSGEPARESRSKTEGHRHRRRRTCPRERDRQDRHAPE------HHPGHGDRLSPGERRSLGRCSHHHSRHRSGVELDWVRHHYTEGERGWGREKFYPDRPRWDRCRYYHDRYAL--Y----AARDWKPFHGGREHERAGLHERPHKDHNRGRRGCEPARER-ERHRPSSPRAGAPHALAPHPDRFSHDRTALVAGDNCNLSDRFHEHENGKSRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKSKKKKKSKDKHRDRDSRHQQDSDLSAACSDADLHRHKKKKKKKKRHSRKSEDFVKDSELHLPRVTSLETVAQFRRAQGGFPLSGGPPLEGVGPFREKTKHLRMESRDDRCRLFEYGQGD--------
USP42 mouse	MTIVDK-TEPSDPSTCQNQPGSCEAVSPEDMDTGSASWGAVSSISDVSSHTLPLGPVPGAVVYSNSSVPEKSKPsPPKDQVLGDGIAPPQKVLFPSEKICLKWQQSHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQTHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVTKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISLKRFANFTGGKIAKDVKYPEYLDIRPYMSQPNGEPIIYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRAVLNQQAYVLFYIRSHDVKNGGESAHPAHSPGQSSPRPGVSQRVVNNKQVAPGFIGPQLPSHVMKNTPHLNGTTPVKDTPSSSVSSPNGNTSVNRASPATASTSVQNWSVTRPSVIPDHPKKQKITISIHNKLPARQGQAPLNNSLHGPCLEAPSKAAPSSTITNPSAIQSTSNVPT--------TSTsPSEACPKPMVNGKAKVGASVLVPyGAEssEEsDEEsKGLAKENGVDMMAGTHSDRPEAAADDGAEASSHELQEPVLLNGANSADSD--SQENSLAFDSASCQVQPELHTENLFSKLNGLPGKVTPAPLQSVPEDRILETFKLTNQAKGPAGEESWTTTGGSSPKDPVSQLEPISDEPSPLEIPEAVTNGSTQTPSTTSPLEPTISCTKEDSSV-VVSAEPVEGLPSVPALCNSTGTILGDTPVPELCDPGDLTANPSQPTEAVKGDTAEKAQDSAMAEVVERLsPAPSVLTGDGCEQKLLLYLSAEGSEETEDSSRSSAVS-ADTMPPKPD--RTTTssCEGAAEQAAGDRGDGGHVGPKAQEPsPAKEKMSSLRKVDRGHYRSRRERSSsGEHVRDSRPRPEDHHHKKRHCYSRERPKQDRHPTNSYCNGGQHLGHGDRASP-ERRSLSRYSHHHSRIRSGLEQDWSRYHHLENEHAWVRERFYQDKLRWDKCRYYHDRYTP-LYTAR-DAREWRPLHG-REHDRLVQSGRPYKDsYWGRKGWELQSRGKERPHFNsPRE-APSLAVPLERHLQEKAALSVQDSSHSLPERFHEHKSVKSRKRRYETLENNDGRLEKKVHKSLEKDTLEEPRVKKHKKSKKKKKSKDKHRDRESRHQQEsDFsGAYsDADLHRHRKKKKKKKRHSRKsEDFIKDVEMRLPKLSSYEAGGHFRRTEGSFLLADGLPVEDSGPFREKTKHLRMESRPDRCRLSEYGQGD--------
USP42 rat	MTIVDK-TEPSDPSTCQNQPGSSEAVSPEDMDTGSASWGAVSSISDVSNHTLSLGPVPGAVVYNNSSVPEKSKPSPPKDQVLGDGIAPPQKVLFPSEKICLKWQQSHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQTHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVTKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISLKRFANFTGGKIAKDVKYPEYLDIRPYMSQPNGEPIIYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLNQQAYVLFYIRSHDVKNGGETTHPAHSPGQSSPRPGISQRVVNSKQAAPGFIGPQLPPHVMKNTPHLNGTTPVKDTPSSSVSSPNGNTSVNRASPATASTSVQNWSVNRPSVIPEHPKKQKITISIHNKLPVRQGQAQLNNNLHGPCLEAPSKAAPSSTITNPSAIQSTSNAPT--------TSVSPSESCPKPMVNGKAKVGSSVLVPYGAEssEESDEESKGLAKENGVDMMTSTQSSRPETADEDG-EASPHELQESVMLNGANSADSD--SRESSLAFDSASCQVQPDLHTENLFNKLNGLPGKVTPAPLQSVPEDKILETFKLTNQAKGPAVEESWTTTGGSsPRASVSQPEPITDETSPLEIPEAVTNGSMKTPSTTSPLEPTISCTKEDSSVVVVSAEPMEVLPSVPALCNSTGTTLGDAPVPESCDPGDLTANPSQPSQAVKGDPAENSENSTLAEVVERLsPAPSVLTGDGCEQKLFLYLSTEGSEEAEDSSRSSAVS-ADTVPPQPD--RT-TSSCAGAAEQAAGDRGDGGSVGPKAQEPsPAKEKMNSLRKVDRGHYRSRRDRSSSGEHVRDSRARPEDHHHKKRRCYSRERPKQERHPANTYCNGGQHLGHGDRASP-ERRSLSRYSHHHSRVRSGLEQDWSRYHHSENEPAWARERFYPDKMRWDKCRYYHDRYTTTLYTAREAAREWRPLHG-REHERLVQSGRPHKDSYWGRKGWDLQSRGKERPHFHSPRE-APGLAVPLERHLQEKAALSVQDSSHSLPERFHEHESVKLRKRRYETLDNNDDHPEKKVHKSLEKDALEEPRAKKHKKSKKKKKSKDKHRARDSRHQQEsDFsGAYsDADLHRHRKKKKKKKRHSRKSEDFIKDVEMHLPKLSSYEAVGHFRRTEGTFLLADGLPVEDSGPFREKTKHLRMESRPDRCHLSEYGQGN--------
	******.:*:****::******:*****:***:**********::***:***:**********::****:******:***:************************:******************************************************:*************************************************************************************************************:*******************************************:*************************************:********************************************:**:*******************.:**:**********::*****::**:**********:*::**:******:*:*******:******:*******::**:*******:*:****:****************:**:*::..::**:::**:*:*::*******::.:*****::*........:::::**:*::*::***:*:::************:********:****::::::::*.:::...::::**::*****::.**********..:.*::**:*:****:**:**:**:*:*:******::****:*:***:*****:*:*::**::.*:*::::::::*.:.:::::*:::::::**:*:*:::.:..*:::::*::*::::***:::. ....*:::::*::*:.::::::::**:::*::****:**:::*::::::**:.**.:.:*::**::*:*****:::::::***:*::::*::::::::*:*:*::::.*::.**:*:..::.:::::*:**:::*:*:.:::::***::*******:.**************:******::*:**:::*:*:*::*::::***::*:**:::......:*:*****:**.*****:*:******.***:*:**:*:*:.*:*.:*:**:**:*:.***:********:. .*... :**:*:*:**.***:*:::::**:**:::**:*:::::::.**:::.***:.**.:::*::::::::::::*::::::*::*****:::*:****:::::*:*.:.***:::*::**:****::*****************:*:*****:**:*:*:********:****************:**:*::**:::*:*::::***::*.*:*::*:*:*::***************:***:*:*****.
Consensus	MTIVDKASEPSDPSACQNQPGSSEAVSPEDMDAGSASWGAVSSINDVSNHTLSLGPVPGAVVYSNSSVPDKSKPSPQKDQALGDGIAPPQKVLFPSEKICLKWQQSHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISLKRFANFTGGKIAKDVKYPEYLDIRPYMSQPNGEPIIYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLNQQAYVLFYIRSHDVKNGGELTHPAHSPGQSSPRPGISQRVVNNKQAAPGFIGPQLPSHMIKNPPHLNGTGPLKDTPSSSMSSPNGNSSVNRASPANASASVQNWSVNRPSVIPEHPKKQKITISIHNKLPVRQCQAQLNNNLHGNCLEAPSKAAPSSTITNPAAIQSTSNAPTMSVSSKVTKPIPRSESCPQPMMNGKAKLNSSVLVPYGAESSEDSDEESKGLAKENGIDMIVSSHSPRQD-A-ADDEEASPHELQEPMTLNGANSADSDSDPKENGLAFDGASCQGQPALHSENLFAKANGLPGKLMPAPLQSLPEDKILETFRLSNQAKGPADEESAPGAERGPPEDRDAQPQPGSDAAEPLEEPDAAANGLSSTKKAPPPRDPGIPATKEDASV-VVSAEAMAVAPEEPALCNAGEDILGDTAPPDLCDPGDLTANASQLSQAAKGDIAEGPRDSALAEAPERLSPAPPARSEDGCEQKLLLHLSGDGARDAQDPSRSLAAPEAAERPPAPDLDRAPAGHCEGAAEQAAGDRGDEDAAAPKAQEPSPAKEKIGSLRKVDRGHYRSRRERSSSGEHARDSRSRPEDHRHRRRRCCPRERDRQDRHAPN-YCNGGQHLGHGDRASPGERRSLGRCSHHHSRHRSGLEQDWSRHHHTENERAWGRERFYPDRPRWDRCRYYHDRYAL-LYTAR-AARDWRPLHGGREHERAGQHERPHKDHNRGRRGCELARRRKERHRFSSPRAGAPHAAAPHERRLQEDAAALVADDNCNLPDRFHEHENGKSRKRRHDSLENNDSHVEKKARRSEQKDPLEEPRAKKHKKSKKKKKSKDKHRDRDSRHQQDSDLSAACSDADLHRHRKKKKKKKRHSRKSEDFIKDSELHLPRLSSLEAVAQFRRAQGGFLLADGLPLEDSGPFREKTKHLRMESRDDRCRLFEYGQGD--------