Multiple Sequence Alignment:
TPM1 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280    )
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TPM1 human MDAIKKKMQMLkLDkENALDRAEQAEADkkAAEDRSkQLEDELVsLQkKLKGtEDELDkysEALKDAQEKLELAEKkAtDAEADVAsLNRRIQLVEEELDRAQERLAtALQkLEEAEkAADEsERGMKVIEsRAQKDEEKMEIQEIQLkEAKHIAEDADrkyEEVARkLVIIEsDLERAEERAELSEGKCAELEEELKtVtNNLKsLEAQAEkysQKEDRyEEEIkVLsDkLkEAEtRAEFAERSVtkLEKsIDDLEDELyAQkLKykAIsEELDHALNDMtsI
TPM1 iso2 human --------------------------------------------------------MCRLRIFLRTASSEHLHERKLRETAEADVAsLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDSDLEsINAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEksIDDLEEkVAHAKEENLsMHQMLDQtLLELNNM
TPM1 iso3 human MDAIKKKMQMLKLDKENALDRAEQAEADkKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKyEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDkYsQKEDRYEEEIKVLsDKLKEAETRAEFAERSVTKLEksIDDLEEkVAHAKEENLsMHQMLDQtLLELNNM
TPM1 iso5 human -----------------------------MA-------GSSsLEAVRRKIRsLQEQADAAEERAGTLQRELDHERKLRETAEADVAsLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDQLYQQLEQNRRLTNELKLALNED---
TPM1 iso6 human MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDsLLAAEEAAAKAEADVAsLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
TPM1 iso7 human
TPM1 iso10 human MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDkYsQKEDRYEEEIKVLsDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTsM
TPM1 mouse MDAIKKkMQMLkLDkENALDRAEQAEADkkAAEDRSkQLEDELVsLQkkLkGTEDELDkysEALkDAQEkLELAEkkATDAEADVAsLNRRIQLVEEELDRAQERLATALQkLEEAEkAADESERGMkVIESRAQkDEEkMEIQEIQLkEAkHIAEDADRkyEEVARkLVIIEsDLERAEERAELsEGkCAELEEELktVTNNLksLEAQAEkYsQkEDkyEEEIkVLSDkLkEAETRAEFAERSVTkLEksIDDLEDELyAQkLkYkAIsEELDHALNDMtsI
TPM1 iso2 mouse MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKsIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
TPM1 iso3 mouse MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSkQLEEDIAAKEKLLRASEDERDRVLEELHKAEDsLLAADETAAKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKsIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
TPM1 iso4 mouse MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDkYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKsIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM
TPM1 iso10 mouse -----------------------------MA-------GSSsLEAVRRKIRsLQEQADAAEERAGSLQRELDQERkLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKsIDDLEDQLYHQLEQNRRLTNELKLALNED---
TPM1 rat MDAIKKKMQMLkLDKENALDRAEQAEADKKAAEDRSKQLEDELVsLQKKLKGTEDELDKysEALKDAQEKLELAEKkAtDAEADVAsLNRRIQLVEEELDRAQERLAtALQkLEEAEkAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRkyEEVARKLVIIEsDLERAEERAELSEGKCAELEEELKtVtNNLKsLEAQAEkYsQkEDkYEEEIKVLSDKLkEAEtRAEFAERSVTKLEKsIDDLEDELyAQkLKyKAISEELDHALNDMTsI
TPM1 rabbit MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTsI
TPM1 pig MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTsI
  ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::..::.:::::::::::************************************************************************************************************::::***:*::::::*::::*:::*******:*************************************::::::::::::::::*:::*:::::.
Consensus MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKEKNKAISEELDHALNDMTSI
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.