Multiple Sequence Alignment:
CARKD Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390)
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CARKD human MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHsIKDMENTLQLVRNIIPPLsStkHKGQDGRIGVVGGCQEytGAPYFAAISALKVGADLSHVFCASAAAPVIKAYSPELIVHPVLDSPNAVHEVEkWLPRLHALVVGPGLGRDDALLRNVQGILEVSkARDIPVVIDADGLWLVAQQPALIHGYRkAVLTPNHVEFSRLYDAVLRGPMDsDDSHGSVLRLSQALGNVTVVQkGERDILSNGQQVLVCSQEGSSRRCGGQGDLLSGSLGVLVHWALLAGPQKTNG--------------SSPLLVAAFGACS--------------------------LTRQCNHQAFQKHGR--STTTSDMIAEVGAAFSKLFET-
CARKD iso2 human MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHSIKDMENTLQLVRNIIPPLSSTKHKGQDGRIGVVGGCQEYTGAPYFAAISALKVGADLSHVFCASAAAPVIKAYSPELIVHPVLDSPNAVHEVEKWLPRLHALVVGPGLGRDDALLRNVQGILEVSKARDIPVVIDADGLWLVAQQPALIHGYRKAVLTPNHVEFSRLYDAVLRGPMDSDDSHGSVLRLSQALGNVTVVQKGERDILSNGQQVLVCSQEGSSRRCGGQGDLLSGSLGVLVHWALLAGPQKTNGGISDLKLtIWGPEIETGVKTRAQGsCGPRTTTPTSPHLLLSPSPQVQPSPGGRVWRLLSHQAVQPPSLPEARSLHHHLRHDRRGGGRLQQAL
CARKD mouse MAVHACG----AAAAVVALLSAAIALQWSPLYAVLQRALsLHTAHATKDMENLFQLVRNIVPALTSkKHKGQDGRIGIVGGCQEyTGAPyFAGISALKVGADLTHVFCAREAAPVIKSYSPELIVHPVLDSSNAVEEVEkWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVIDADGLWLVAQQPALIHSYHKAILTPNHVEFSRLWEAVLSsPMDSNDLkGSTLKLSQALGnITVVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMVHWALRAGPEKTNG--------------SSPLLVAAWGACT--------------------------LTRECNRQAFQKYGR--STTTTDMITEVGTAFSRLFTT-
CARKD rat MGIRCVA----IRACG----------------GVLQRALSLHTAHATKDMDNLFQLVRNIVPALTSKKHKGQDGRIGIVGGCQEyTGAPYFAGISALKVGADLTHVFCAREAAPVIKSYSPELIVHPVLDSSDAVEEVEkWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVIDADGLWLIAQRPALVHGYQKAVLTPNHVEFSRLWDAVLSSPMDTSNHSGSVLKLSQALGNITIVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMAHWALRAGPEKTNG--------------SSPLLVAAWGACT--------------------------LTRECNHLAFQKYGR--STTTTDMIAEVGAAFSKLFTT-
  *:.::.:....::*:::::::::.::...::.:**:**:**::**::***:*::******:*:*:*:**********:**************:**********:*****::******:*************::**:**********************:**:**:****::****************:**:***:*:*.**:***********::***::***:.:..**:*:*******:*:*****:*::*********:*********************::****:***:****              :::::::*.*:*.                          ::*.::::*:*:.::  ::::.::::::::::::*:.: 
Consensus MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLQRALSLRKAHAIKDMENLLQLVRNIIPALSSKKHKGQDGRIGIVGGCQEYTGAPYFAAISALKVGADLSHVFCARAAAPVIKAYSPELIVHPVLDSPNAVEEVEKWLPRLHALVVGPGLGRDDALLRNVRGILESSKARDIPVVIDADGLWLVAQQPALIHGYRKAVLTPNHVEFSRLWDAVLRGPMDSDDSHGSVLRLSQALGNITVVQKGERDIISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVLVHWALRAGPQKTNG--------------SSPLLVAAWGACT--------------------------LTRECNHQAFQKYGR--STTTTDMIAEVGAAFSRLFTT-
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.