Multiple Sequence Alignment:
CARKD Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390 )
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CARKD human MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHsIKDMENTLQLVRNIIPPLsStkHKGQDGRIGVVGGCQEytGAPYFAAISALKVGADLSHVFCASAAAPVIKAYSPELIVHPVLDSPNAVHEVEkWLPRLHALVVGPGLGRDDALLRNVQGILEVSkARDIPVVIDADGLWLVAQQPALIHGYRkAVLTPNHVEFSRLYDAVLRGPMDsDDSHGSVLRLSQALGNVTVVQkGERDILSNGQQVLVCSQEGSSRRCGGQGDLLSGSLGVLVHWALLAGPQKTNGSSPLLVA-AFGACSLTRQCNHQAFQKHGRSTTTS---DM--------IAEVGAAFSKLFET--------------------------------
CARKD iso2 human MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHSIKDMENTLQLVRNIIPPLSSTKHKGQDGRIGVVGGCQEYTGAPYFAAISALKVGADLSHVFCASAAAPVIKAYSPELIVHPVLDSPNAVHEVEKWLPRLHALVVGPGLGRDDALLRNVQGILEVSKARDIPVVIDADGLWLVAQQPALIHGYRKAVLTPNHVEFSRLYDAVLRGPMDSDDSHGSVLRLSQALGNVTVVQKGERDILSNGQQVLVCSQEGSSRRCGGQGDLLSGSLGVLVHWALLAGPQKTNGGISDLKLtIWGPE-IETGVKTRAQGsCGPRTTTPTSPHLLLSPSPQVQPSPGGRVWRLLSHQAVQPPSLPEARSLHHHLRHDRRGGGRLQQAL
CARKD mouse ----MAVHACGAAAAVVALLSAAIALQWSPLYAVLQRALsLHTAHATKDMENLFQLVRNIVPALTSk
KHKGQDGRIGIVGGCQEyTGAPyFAGISALKVGADLTHVFCAREAAPVIKSYSPELIVHPVLDSSNAVEEVEkWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVIDADGLWLVAQQPALIHSYHKAILTPNHVEFSRLWEAVLSsPMDSNDLk
GSTLKLSQALGnITVVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMVHWALRAGPEKTNGSSPLLV-AAWGACTLTRECNRQAFQKYGRSTTTTD-----------MITEVGTAFSRLFTT--------------------------------
CARKD rat ----MAVCPYGAAAVVMALLSAAIAFHCSPLLAVLQRALSLHTAHATKDMDNLFQLVRNIVPALTSKKHKGQDGRIGIVGGCQEyTGAPYFAGISALKVGADLTHVFCAREAAPVIKSYSPELIVHPVLDSSDAVEEVEkWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVIDADGLWLIAQRPALVHGYQKAVLTPNHVEFSRLWDAVLSSPMDTSNHSGSVLKLSQALGNITIVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMAHWALRAGPEKTNGSSPLLV-AAWGACTLTRECNHLAFQKYGRSTTTTD-----------MIAEVGAAFSKLFTT--------------------------------
  ....:::.:::*:*:*:******:*:..:**.***:**:**::**::***:*::******:*:*:*:**********:**************:**********:*****::******:*************::**:**********************:**:**:****::****************:**:***:*:*.**:***********::***::***:.:..**:*:*******:*:*****:*::*********:*********************::****:***:****::::*:..::*::.:::.::..*:::.*::***..  ..       .::::*:::::*:.:                                
Consensus MVTRAAAGTAGAAAVVVALLSAAIALYGPPLDAVLQRALSLRKAHAIKDMENLLQLVRNIIPALSSKKHKGQDGRIGIVGGCQEYTGAPYFAAISALKVGADLSHVFCARAAAPVIKAYSPELIVHPVLDSPNAVEEVEKWLPRLHALVVGPGLGRDDALLRNVRGILESSKARDIPVVIDADGLWLVAQQPALIHGYRKAVLTPNHVEFSRLWDAVLRGPMDSDDSHGSVLRLSQALGNITVVQKGERDIISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVLVHWALRAGPQKTNGSSPLLV-AAWGACTLTRECNHQAFQKYGRSTTTTD-----------MIAEVGAAFSRLFTT--------------------------------
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.