Multiple Sequence Alignment:
SET Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290)
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SET human MAPKRQsPLPPQKKKPRPPPALGPEETsASAGLPKKGEkEQQEAIEHIDEVQNEIDrLNEQAsEEILkVEQkYNKLRQPFFQkRSELIAkIPNFWVTTFVNHPQVSALLGEEDEEALHyLTRVEVtEFEDIksGYRIDFyFDENPyFENkVLSkEFHLNEsGDPsSkSTEIkWKsGKDLTkRSSQTQNkAsRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
SET iso2 human -M-----SAP-------AAkVsKkELNsNHDGADEtsEkEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQkRSELIAKIPNFWVTTFVNHPQVsALLGEEDEEALHYLTRVEVTEFEDIkSGYRIDFYFDENPYFENkVLSkEFHLNESGDPSSKSTEIKWKSGKDLTKRSsQTQNKAsRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
SET mouse MAPKRQsAILPQPKKPRPAAAPKLEDkSAsPGLPK-GEkEQQEAIEHIDEVQNEIDRLNEQAsEEILkVEQKYNKLRQPFFQkRSELIAkIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIksGYRIDFYFDENPyFENkVLSkEFHLNEsGDPSSkSTEIkWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD
SET iso2 mouse -M-----SAP-------TAKAsKKELNsNHDGADEtsEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSkEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD
SET rat MAPKRQSAILPQPKKPRPVAAPkLEDkSAsPGLPk-GEkEQQEAIEHIDEVQNEIDRLNEQASEEILkVEQkYNKLRQPFFQkRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIkSGYRIDFyFDENPYFENkVLSKEFHLNESGDPSSkSTEIkWKSGkDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD
SET iso2 rat MM-----SAP-------TAKASkkELNSNHDGADETsEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD
  ::.....:::.......:::::::*::*:::*:::.:***************************************************************************************************************************************************************************************************************:*:**************************:*:**************
Consensus MAPKRQSSAPPQ-KKPRPAKASKKELNSAHDGADETGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.