Multiple Sequence Alignment:
HLAB Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370 )
           |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         | 
HLAB human MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGyVDDTQFVRFDSDAASPREEPRAPWIEQEGPEyWDrNTQIYkAQAQTDRESLRNLRGYYNQSEAGSHTLQSMyGCDVGPDGRLLrGHDQYAYDGkDyIALNEDLrSWtAADTAAQItQRkWEAAREAEQRRAYLEGECVEWLRRyLENGk
DkLERADPPktHVTHHPIsDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQk
WAAVVVPsGEEQRYTCHVQHEGLPkPLTLRWEPSSQSTVPIVGIV------AGLAVLAVVVIGAVVAAVMCRRkSSGGkGGsySQAACsDsAQGsDVsLtA---
HLAB iso7 human MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIV------AGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA---
HLAB iso8 human MLVMAPRTVLLLLSAALALTETWAGSHSMRYFDTAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIFKTNTQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHNQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARVAEQDRAYLEGTCVEWLRRYLENGKDtLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIV------AGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA---
HLAB iso9 human MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIV------AGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAAssDSAQGSDVSLTA---
HLAB mouse ---MALRRLLLLLVAALKLTETRAGSHSLRYFTTAVSRPGLGEPRFIIVGYVDDTQFVRFDsDAENPRMEPRAPWMEQEGPEYWERNTQVSKENEQSFRVSLGTALSYYNQSKGGSHTLQWLVGCDLGPDGSLLRGYEQSAYDGRDYLALNEDLITWTAADLAALKTRSKLEQAGLAEKRRAYLEVDCLTWLRRYLELGKETLLHTDPPKAHVTHHPSSQGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPSGDGTFQKWASVMVPFGEEPRYTCHVEHEGLPEPLTLRWEPPPSTDSYMVIIAVLVVLGAVII------IGAVVAFVMKRGRNTGGKVRDYAQDPGRDSPQSSDISLLEL--
HLAB iso2 mouse ---MALGRLLLLLAAALTLTKTGAGSHSLRYFETSVSRPGFGKPRFISVGYVDDTQFVRFDSDAKNPRYEPRAPWMEQEGPEYWERNTRRVKGSEKRFQESLSTLLSYYNQSKGGIHTFQKLSGCDLGSDGRLQSGYLQFAYDGLDYIALNEDLETWTAADVAAQETRRKWEQAGAAEKHRTYLEGKCLMWLHRYLELGKEMLLRTDPPKAHVTHHPRSQGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQkWASVVVPLGKEQnYTCHVYHEGLPEPLTLRWEPPPYTVSNMVIIAVLVVLGAVIVIGAVVIIGVMVSFVMKRRRNKGGQGEDCALAPSRDSAQSSDISLLDCKA
  :::**::::****:***:**:*:*****:***.*::****:*:****:****************::**:******:********:***::.*::::::::**:::::*****::*:**:*:::***:*:**:*::*:.*:****:**:******::*****:**::*::*:*:*::**::*:***:.*::**:****:**::*:::****:******:*::::************:******::**::***:*******:**:******:*:**:*:*::*****:*****:********::::::::*:*:......*:::::::::**::*::**:*::::**:::::::::::**:*:**:**::   
Consensus MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIV------AGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA---
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.