(        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670       680       690       700       710       720       730       740       750       760       770       780       790       800       810       820       830       840       850       860       870       880       890       900       910       920       930       940       950       960       970       980       990      1000      1010       )
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EPB41 human	MTTEKsLVTEAENsQHQQ-KEEGEEAINSGQQEPQQEESCQ-TAAEGDNWCEQKLKAsNGDtPtHEDLTKNKERTSESrGLsRLFssFLKRPKsQVsEEEGKEVEsDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPsLDLHsLssAEtQPAQEELREDPDFEIKEGEGLEECsKIEVKEEsPQsKAEtELKAsQKPIRKHRNMHCKVSLLDDtVyECVVEkHAKGQDLLkRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAkEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTk K361-ac K361-m1 K361-ub ELEEk K366-ac K366-ub VMELHk K372-m1 K372-ub SyRSMtPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQyEsTIGFk K466-ac K466-ub LPSYRAAKKLWKVCVEHHTFFRLTsTDtIPKSkFLALGskFRYsGRTQAQTRQAsALIDrPAPHFERTASKRAsRsLDGAAAVdsADRsPRPtsAPAItQGQVAEGGVLDAsAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIyIRHsNLMLEDLDKsQEEIKKHHAsISELkKNFMESVPEPRPSEWDKRLstHsPFRtLNINGQIPTGEGP------------------------------------------------------------------------------------------------------------------------------------------------------PLVKTQtVTISDNANAVkSEIPT-KDVPIVHTETKTITyEAAQTDDNSGDLDPGVLLtAQTITSEtPSSTTTTQITKtVkGGIsETRIEKRIVItGDADIDHDQVLVQAIKEAkEQHPDMsVtKVVVHQEtEIADE
EPB41 iso2 human	MTTEKSLVTEAENSQHQQ-KEEGEEAINSGQQEPQQEESCQ-TAAEGDNWCEQKLKASNGDtPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK---------------------------------KKRERLDGENIyIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHsPFRTLNINGQIPTGEGP------------------------------------------------------------------------------------------------------------------------------------------------------PLVKTQTVTISDNANAVKSEIPT-KDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
EPB41 iso4 human	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHCKVSLLDDTVyECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQAsALIDRPAPHFERTASKRAsRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK---------------------------------KKRERLDGENIyIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLsTHSPFRTLNINGQIPTGEGP------------------------------------------------------------------------------------------------------------------------------------------------------PLVKTQTVTISDNANAVKSEIPT-KDVPIVHTETKTItyEAAQ----------------------------------TVKGGIsETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
EPB41 iso5 human	MTTEKSLVTEAENSQHQQ-KEEGEEAINSGQQEPQQEESCQ-TAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVE-----------------------------------TWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWk------------------------------------------------------DLDKsQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGP------------------------------------------------------------------------------------------------------------------------------------------------------PLVKTQTVTISDNANAVKSEIPT-KDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
EPB41 mouse	MTTEKSLAAEAENSQHQQQKEEGEGATNSGQQETQLEEASQAAAAEGSDQGEQKLKASNGDtPTHEDLTKNKERTSESRGLSRLLssFLKRPKsQVsEEEGREVESEKEKGEGGQKEIELGNsLDEDIILKAPIAAPEPELKtDPsLDLHSLSsIETQPAQEEHREDPDSETKEGEGIEECsGTEVKE-DPESRAEREPEASQKPVRRHRNMHCKVSLLDDTVyECVVEkHAkGQDLLKRVCEHLNLLEEDYFGLALWDSATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGMDYVSDFKLAPNQTkELEEkVMELHkSYRSMTPAQADLEFLENAkkLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEHyESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDtIPKSKFLALGSKFRysGRTQAQTRQAsALIDRPAPHFERTASKRAsRsLDGAAAAEsTDRsPRPtsAPAIAQsQVtEGPGA-------PIkKTPKEAVKVEEKRGEEPAEPAEPEPTEAWKVEKTHTEVTVPTSNGDQTQKLAGKGEDLIRMRKKKRERLDGENIyIRHsNLMLEDLDKsQEEIKKHHAsIsELKKNFMESVPEPRPSEWDKRLstHsPFRTLNINGQVPTGDGP------------------------------------------------------------------------------------------------------------------------------------------------------PLVKTQTVTISDTANAVkSEIPT-KDVPIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGIsETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQEtEIsEE
EPB41 iso3 mouse	-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------XTPKEAVKVEEKRGEEPAEPAEPEPTEAWK------------------------------------------------------DLDKsQEEIKKHHAsISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQVPTGDGSVNGIRTEEVATVTKGPSTYPASEWECPKQsVVPSQSLMTtPPAsPQsFGsGsLsINsKEAEEKEQGAAGYLDAEEMPTGPSGECLGVEEQASAFSFPVTPASCQLQLGGEKADssEELGAAAETLETQSGSFLDsPVGNQFPTLIRSFQPPLVkTQTVTISDTANAVKSEIPT-KDVPIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE
EPB41 iso6 mouse	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGMDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRsLDGAA-AESTDRsPRPTSAPAIAQSQVTEGPGA-------PIKKTPKEAVKVEEKRGEEPAEPAEPEPTEAWK------------------------------------------------------DLDKsQEEIKKHHAsISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQVPTGDGV------------------------------------------------------------------------------------------------------------------------------------------------------KKTSILPSGRKGEENSKRPERSTERTLPQ----------------RENEEIAPKVSIPIPE---EH----KALKKCHLYSSAFPSPRIPFMMS----------FLLVLALA----------VWWLIFL--------
EPB41 rat	MTTEKSLAAEAENSQH--QKEEGEGATNSGQQESQLEEASQAAAAEGSNQGEQKLKASNGDTPTHEDLTKNKERTsESRGLsRLLSSFLKRPKsQVsEEEGREVESEREKGEGEQKETELGTSLDEDVILKAPIAAPEPELKTDPSLDLHsLSsIETQPAQEEHREDPDSETKEGEGIEECSGTEVKE-DPESRAEREPETSQKPIRRHRNMHCKVSLLDDTVyECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAVWDSTTSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTVQSELGDYDPELHGVDYVSDFKLAPNQTRELEEkVMELHkSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTLPKSKFLALGSkFRYSGRTQAQTRQASALIDRPAPHFERTASKRAsRsLDGAAAAEsTDRsPRPTSAPAIAQSQVMEGPGA-------PAKKAPKEAVKVEEKRGEEPAEP-EPEPTEAWK---------------------------------KKRERLDGENIYIRHsNLMLEDLDKsQEEIKKHHAsISELKKNFMESVPEPRPSEWDKRLSTHsPFRtLNINGQVPtGDGP------------------------------------------------------------------------------------------------------------------------------------------------------PLVKTQTVTISDTANAVKSEIPT-KDVPIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIsEE
	.................. ...................... .........................................................................................................................................................................::::::::::::::::::...................................:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.......:::*::**:**:*:*:::**:*::*********                                 .....................*****************************************************:***:*:                                                                                                                                                      ::::::::::::::*::::*::* :::*::::::::::::::::.:.:::::::::::::::::::.:::::::::::::::::::**:::::::::::::::::**:*::::::::::::*::::::::::::::
Consensus	MTTEKSLVTEAENSQHQQ-KEEGEEAINSGQQEPQQEESCQ-TAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKE-SPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKEAVKAEEKREDEPAEQAEPEPTEAWK---------------------------------KKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGDGP------------------------------------------------------------------------------------------------------------------------------------------------------PLVKTQTVTISDNANAVKSEIPT-KDVPIVHTETKTITYEAAQTDDNNGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE