Multiple Sequence Alignment:
laforin Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390 )
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laforin human --------------------------MRFRFGVVVPPAVAGARPELLVVGsRPELGRWEPRGAVRL-RPAGTAAGDGALALQEPGLWLGEVELAAEEA-----AQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNE----NNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGL-----------------AYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCN----AGVGRSTAAVCGWLQYVMGWNLRKVQYFLM---AKRPAVyIDEEALARAQEDFFQkFGKVrSSVCSL
laforin iso4 human --------------------------MRFRFGVVVPPAVAGARPELLVVGSRPELGRWEPRGAVRL-RPAGTAAGDGALALQEPGLWLGEVELAAEEA-----AQDGAEPGRVDTFWYKFLKREPGGELSWEGIASRRLPPAQSGS----SGPH----PQP-GP-RPRAGPAGPGGARPGLFARVPAHsPG---------------------------DLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
laforin iso9 human MHPKEGAEQHVFSPVPGAPTPPPNRCGRLVLGPRLPA-AGTPGPGIRAAAARHALPLWGGGATRRGRRPAGAAGGGVAARAGA----LGAARCRPPEAGRHRGGRRGPGPAGAGPVARGGGAGGRGGGAGRGGAGPRGHVLVQVPEAGAGRRALLGRYCQQT----PAPGAERELRPAPPTGASASGRPR----RPRRRASRAFCPRPCA-----LPGRPGLTL-----------LCRPRCRRQPRLRLPTDSLDPYSAPGRLPAHSVACPSDLVSAHPVLSFFPTAPASRASALRLPPGAPFALRVPLDLRVPPFAGPLAARPRAADGFNSPTPPWLGFVSSFSCSNSLKKTQNDPTNETSVFANP------R------------QQCAT
laforin mouse --------------------------MLFRFGVVVPPAVAGARQELLLAGSRPELGRWEPHGAVRL-RPAGTAAGAAALALQEPGLWLAEVELEAYEE------AGGAEPGRVDTFWYKFLQREPGGELHWEGNGPHHDRCCTYNE----DNLVDGVYCLPVGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQLEHVTIKLKHELGVTAVMNFQTEWDIIQNSSGCNRYPEPMTPDTMMKLYKEEGL-----------------SYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCN----AGVGRSTAAVCGWLHYVIGWNLRKVQYFIM---AKRPAVYIDEDALAQAQQDFSQKFGKVHSSICAL
                            :::::*:::*:::::::::::::::*::*::*::.:::*: ****:*:*::*:::::::::*:::::::.*:     .:.*::*:::::::::::::::**::.::*::::....::..:    ..:..:.::::.:...:::*::.:..:::...:.::::.:....:....:..:.:::..:.....:...:*.:.................:.:.:....:......:.:.:.                 .....:::.::.:.:....:.:..::...:.......:...    .::.........::..:.............   .....:.:.......................:..
Consensus --------------------------MRFRFGVVVPPAVAGARPELLVAGSRPELGRWEPRGAVRL-RPAGTAAGDGALALQEPGLWLGEVELAAEEA-----AQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPRHDRCCQYNE----RNLVDGVYCQPIGHWIEATGHTNEMKHTPDFYANIAGHQAMHYSRILPNIWLGSCPRQCEHVTIKLKHELGITAVMNFQTEWDI-QNSSGCNRYPEPMTPDTMIKLYREEGL-----------------AYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHIVYVHCN----AGVGRSTAAVCGWLQYVIGWNLRKVQYFIM---AKRPAVYIDE-ALA-AQ-DF-QKFGKV-SSQCAL
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.