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PDE3A human	MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAE-AAPREHLGSQLIAGTKEDIPVFkRRRRsssVVsAEMsGCSSKSHRRTsLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVtsLsENYTCsDsEEsSEKDkLAIPKRLRRsLPPGLLRRVsstWttttSATGLPTLEPAPVRRDRsTsIkLQEAPSS---SPDsWNNPVMMTLTkSRsFtSSyAISAANHVkAKKQSRPGALAkIsPLssPCssPLQGtPASSLVSkISAVQFPEsADttAkQsLGsHRALTYtQsAPDLsPQILtPPVICSSCGRPYsQGNPADEPLERSGVATRTPsRTDDTAQVTSDYETNNNSDSSDIVQNEDEtECLREPLRKAsACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFkIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKkHFDFVAkFNGkVNDDVGIDWTNENDRLLVCQMCIkLADINGPAkCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKkVIEEEQRLAGIENQsLDQtPQSHSSEQIQAIkEEEEEKGKPRGEEIPtQKPDQ
PDE3A mouse	MAVRGEAAQDLAKPGLGGASPARVARGN-HRHRGESSPSPRGSGCCWRALALQPLRRSPQLSSALCAGSLSVLLALLVRLVGGEVGGELEKSQEAAAEE--EEEEGARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQLSLGVGDGRLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVAWTSVLRTVALVSLERFKVAWRPYLAYLAAVLGLLLARYAEQILPQCSGPAPPRERFGSQLSARTKEEIPGWKRRRRsssVVAGEMSGCSGKSHRRtsLPCIPREQLMGHSEWDHKRGPRGSQ-SGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKQAISKRLRRsLPPGLLRRVsSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPsAVNPDSWNAPGLTTLTKSRsFtSSYAVSAANHVKAKKQNRPGGLAKIsPVPsPsssPPQGsPASSPVSNSASQQFPESPEVTIKRGPGSHRALTYTQSAPDLSPQIPPPSVICSSCGRPYSQGNPADGPSERSGPAMLKPNRTDDTSQVTSDYETNNNSDSSDILQNEEEAECQREPQRKAsACGTYTSQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLMENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKMYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDSDDsGDtDDPEEEEEEAETPHEDEACESSIAPRKKSFKRRRIYCQITQHLLQNHMMWKKVIEEEQCLSGTENQSLDQVPLQHPSEQIQAIKEEEEEKGKPRAEETLAPQPDL
PDE3A rat	MAVRGEAAQDWAKPGLRGPSPAPVARGD-HRCRGGSPSSPRGSGCCWRALALQPLRRSPQLSSALCAGSLSVLLALLVRLVGGEVGGELESSQEAAAEE--EEEEGARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQLSLGVGDGRLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVALTSALRTVALVSLERFKVAWRPYLAYLAAVLGLLLARYAEQLLPQCSGPAPPRERFGSQSSARTKEEIPGWKRRRRSSSVVAGEMSGCGGKSHRRTSLPCIPREQLMGHSEWDHKRGSRGSQ-SGTSVTVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPVLMTLTKSRSFTSSYAVSAANHVKAKKQNRPGGLDKISPVPSPSSSPPQGSPTSSPVSGIASVQFPESPEVTTKRGPGSHRALTYTQSAPDLSPQIPPSPVICSSCGRPYSQGNPADGPSERSGPAMQKPNRTDDTSQVTSDYETNNNSDSSDILQNDEEAECQREPLRKASACGTYTPQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKAYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKDLHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDSDDSGDTDDPEEEEEEAETPHEEETCENSEAPRKKSFKRRRIYCQITQHLLQNHMMWKKVIEEEQCLSGTENQAPDQAPLQHSSEQIQAIKEEEEEKGKPRAEETLAPQPDL
PDE3A cow	MAVPGEAARVGATPGHWEARPAPA--------AGPASPRDVGCRGCWGARVLRPLRRSRKLSSALCAGSLSFLLALLVRLVRGEIGCDLERSKEEA-TEEEEAAPAAEGGVFPGPRGGAPGGGAPLGPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAVCCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVALISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQYSG-AAPREHFGSQLIAGTKEEIPVFKRRRRSSSVVSAEMSGCSSKSHRRTsLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTIQAIHKPRVNPIVSFSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKLHEAPSSSAINPDSWKNPVMMTLTKSRSFTSSYAVSASNHVKAKKQNRPGSLVKISPLSSPCSSPLHGTPASSPVSKVSAVQFPESSDTTAKSGLSSHRALTYTQSAPDLSPQILNPPVICSSCGRPYSQGTSADGPLERSGAAIRTPTRTDDITQVTSDYETNNNSDSSDIVQNEDETEGPREALRKTSSCSTYAPETMMFLEKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVEKIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIGYREIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSASDSDSDSGFTHGHMGYVFSKMYNVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDEVGIDWTNENDRLLVCQMCIKLADINGPAKSKELHLQWTEGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEE--APNEEETCENNESPRKKIFKRRKVYCQITQHLLQNHKMWKKVIEEEQRLAGIEDQ----SPQQHPSEQIQAIREEDEEKGKQKGEETPAPKPNQ
	***:*:**::.::*::.::::*:::... :..::.:::::.*:::**::::*:***:*::***********:*********:**:*::**.::*:*::*..*::::*:****************.*:*****:***************:****************:**:******::****:::*********:****::**************:*:**::***:*:*****************:***:*****:**:***.::.*:***::***::*:***:**::**********::*****::***************************:****.****:*******************************************:**********.:::***********::****:**:*****************************************:***::****:::.:****::*:::*************:**:********:***:*:****::**:***::*:*:**:**..:::*****:::*:*.:::******************:.::*************::**:*:****:*..:*.****::*****************:**::*:*:.**::**:*:*:**:::**:**:******************:************:*:*****************************:***************:***************************::**:****:********************:*:*:****************************************************************************:**********************************:****:*****************************:*:***:**:**::*******************************************:*************:***:*************:.:*:*:*:**::::*:**.****::************:**********:*:*:*:*:.::.*::*:*******:**:*****:::**:::::*::
Consensus	MAVRGEAARDRAKPGHRGASPAPVARGD-HRRAGPASPRDRGCRCCWRALALQPLRRSRQLSSALCAGSLSFLLALLVRLVRGEVGCDLERSQEAAAEEEEEAAEGARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQIGLGVGDDRLLSLPAAGVLLSCLAAATWLVLRLRLGVLMIALTSALRTVALISLERFKVAWRPYLAYLAAVLGILLARYAEQILPQCSGPAAPRERFGSQLIARTKEEIPGFKRRRRSSSVVAAEMSGCSGKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVSFSENYTCSDSEEGLEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKLHEAPSPSAVNPDSWNAPVLMTLTKSRSFTSSYAVSAANHVKAKKQNRPGGLAKISPLPSPCSSPLQGSPASSPVSKIAAVQFPESPDTTAKRGLGSHRALTYTQSAPDLSPQILPPPVICSSCGRPYSQGNPADGPLERSGPAMRKPNRTDDTSQVTSDYETNNNSDSSDILQNEDEAECQREPLRKASACGTYAPQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVINDHGSASDSDSDSGFTHGHMGYVFSKMYNVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLRWTEGIANEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVDDSDDSGDTDDPEEEEEEAEAPNEEETCENNEAPRKKSFKRRRIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQAPQQHPSEQIQAIKEEEEEKGKPRAEETLAPQPDQ