TOPBP1 human
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---------------------------------------------------------------------------MSRNDkEPFFVKFLkSSDNSkCFFKALESIkEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHLkKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVsVTHLIAGEVGsKkYLVAANLkkPILLPSWIKTLWEkSQEKKItRytDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVkHGGQYMGQLkMNECTHLIVQEPkGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYkTEPRPEAkTMPNSStPtsQINT--IDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVsAFQAPEDLLDGCRIYLCGFsGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNkSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLsQyENGssTVVEAKTSEA-----RPFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFsQKSFLVLGFSNENESNIANIIKENAGkIMSLLsRTVADYAVVPLLGCEVEATVGEVVTNTWLVtCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENstkEERsLETEITNGINLNSDTAEHPGTRLQTHRKtVVtPLDMNRFQSkAFRAVVSQHARQVAAsPAVGQPLQKEPsLHLDtPSKFLSKDKLFKPsFDVkDALAALEtPGRPsQQkRKPstPLsEVIVKNLQLALANssRNAVALsAsPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMsLDIsAVQDGRLCNsRLLsAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSGVLtQtLEMRENFQKQLQEIMSATSIVKPQGQRTsLSRSGCNSASStPDSTRSARSGRSRVLEALRQsRQTVPDVNTEPsQNEQIIWDDPTAREERARLAsNLQWPSCPTQYSELQVDIQNLEDsPFQKPLHDsEIAKQAVCDPGNIRVTEAPK-HPIsEELEtPIKDSHLIPtPQAPSIAFPLANPPVAPHPREkIITIEETHEELkKQYIFQLSSLNPQERIDYCHLIEkLGGLVIEkQCFDPTCTHIVVGHPLRNEkYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFkRLLQSGGAkVLPGHSVPLFkEATHLFSDLNkLkPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLsQkRKAPTEKNKIKRPRVH |
TOPBP1 mouse
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---------------------------------------------------------------------------MSRNDQEPFLVKFLKSSDNSECFFKALESIKELQSEDYLQIITDEEALKIRENDKSLYICDRFSGTVFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDVTVSCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSkKYLVAANLKKPILLPSWIKTLWEKSQEKKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAETRVEAKMVPDTSTPTAQSN---AESHTLADVSHISNINGSCVNETMFGSTTSKLECSLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDDVRQFWSKSSHRPHVVGAKWLLECFTKGYILPEESYIHTNYQPAGIAVSDQPGNQTAVL-DKSGSFSKSALVPAERLQQADEDLLAQYGNDDSTMVEAKLSEALEPEVGPCPGSAHREPCDDSTHISVQEENKSSVSHCILDDSTVREEGLFSQKSFLVLGFSVENKCNIVDIIREHAGKIVSLPSRIVADYAVVPLLGCEVDVTVGEVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSGVTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKANAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFLVDNAPKQEQVLETKIPNGVSSNPDLPAHPDAHLEIHRKKAVTPLDMNRFQSRAFRAVISQQRGQDPTFPPVRQPLTKEPsLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAAS-QKRKLssPLsEVIVRNLTVALANSSRNTDSHsAsPQLKGAHLEEEETRKPLDSVVVCVSKKLSKKQSELNGVAASLGAEYRWSFDETVTHFIYQGRANDSNREYKSAKERGVHIVSEHWLLECAQEYKHLPESLYPHTYNPKMSLDINTVQDGRLCNSRAPLAVSAsKDDGPDHLSVEGNETNTMGTNDKESPLLNGSGRDDCKGALTQALEMRENFQKQLQEIMSATCIVKTPAQKTCMSRSSCNSASSTPDSARSVRSGRSRVLEALRQsRQAVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSDPTQHSELQVEIKMPDDsPSRKPVYHSEIAEQASC------VTQAPG-HPGSEEPEPPVAERPLIPEPQAPAVASPLAKPPVAPQPADKIETQEETHRKVKKQYVFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACKTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAAMRWRKRIQQSQESGIVEGAFSGWKAILRVDRPREAGFKRLLQAGGAkVLSGHPEPLLkDATHLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMLESPPCADNYRVSEAALF--HNKKGGPGLPQKRKTPAE-NVVKRPRVH |
TOPBP1 rat
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MTPLPPEEALRPLVWRESRFLVLALPGTAALTSGWGRRRGRGLRAGLAPDPSRRPAGRAPPDLVPVGPRAPPSSAMSRNDQEPFFVKFLKSSDNSECFFKALESIKELQSEEYLQVITDEEALRIKENDKSLYICDRFSGTAFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDITISCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPAWIKTLWEKSQEKKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAEPRAAVKTVPDTSTPTAQSGSAAAENHRLADVSHISNINGSCVNETMFGSTTSKLECTXENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIMGDYEDDVRQFWSKSSHRPHVVGAKWLLECLVKGYILPEESYIHANYQPDGIPVSDQPRNQTTVL-EKSGTFSKKDFVPNEKFQQTDEDLLAQYVHDDSTIVEAKLSEAIEPEVGPCGGSAHVEPCDDSTHISVQEENKSSVSHCLLDGSTVPEEGLFSQKSFLVLGFSVENECNIVNIIREHAGKIVSLPSRIVADYAVVPLLGCEVEATVAEVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSGMTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKSNAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARMGKRADENHFLVDSAPKQEQVLETNIPNGVSPNPDSPAHPDAHLEIHRQKAVTPLDMNRFQSKAFHAVISQHNRQGLASPPVRQPPKKEPSFHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAAS-QKRKLSSPLSEVIVRNLTTALANSSRNTGCLSASPQLKGAHLEKEETPKPLDKVVVCVSKRLSKKQSELNGVAASLGAEYRWSFDETVTHYIYQGRANDSNREYKSAKERGVHVVSEHWLLECAQEYKHLPESLYPHTYNPKMSLDISTVQDGRLCDSRLPSALSASKDDEPDHLSVEENATETLGTHSRESALLNGNGRDDCKGAMFQCLEMRENFQKQLQEIMSATSIVRTPAQKTCMSRSSCNSASSTPDSTRSARSGRSRVLEALRQSRQIVPDINTEPSQNEQIIWDDPTAREERARLASNLQWPSYPTQYSELQVEIKKLDDSPSRKPVYHSEIAGQASC------VTQAPGQHPGSEEPEAPAAERNLIPEPQAPSVAFPLAKPPVAPQPEDKIETLEETHGKLKKQYVFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACRTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAAMRWRKRIQQSRESGIAEGAFSGWKVILRVDRPREAGFKRLLQAGGAKVLPGHPEPLFKDATHLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMMESPPCADNYRVSETALF--RNKEGGPGLPQKRKTPAE-NVIKRPRVH |
...........................................................................*****:***:**********:***********:***:***:**:****:*:***:******:***::*****:***********:***:**:************:***:*:*****:*:**************************************************:***************:***:********************:*::**:*****:*******************************:********:***:***************:*:*:::*::*::****:*::...:::::*:***:*****:***:*::::*::****::********:*:*************************************************:***:*:::***:**:**************:.***:*:**:***:****::*:**::*.:::::*..*:::***::::*:*:.:*:*****:**.:::**.****:***.:::::*:.:*:*:**::******:****:******.:*.**:.****************:**::**::**:*:****:**:**:**************::**:*************:***:***********:**:*:*************:***::**:****:*******:****:******:******:**::**********:****:*:*******.******:***:::::*:*::***.*:**::.*:*.::**:::*::**:::***********:**:**:**:::*.:::*:*:**:.****:*********************:*********:::*.****:*:*******:**:.********:.::*******:*::*:**::***::*******:**********:******:***********:*****:**:******:******:*******:****:********************::*******:**:::*:*::***:**:*::*:*::.:::*:.:**:::**:*::*:**:::*:******************:**::::*:*::***:**********:**:****************:***:********************************.***:*****:*:.::***::**:::****.**:*......**:**:.**:***:*:*::::.***:****::*:***:*****:*::**:*.****.::****:**:****:*******:**::***:******:**:***:***:**********:************:**:***:****************:*::::::*::**********:***::****:********:**:**::**********:******:**::**:*:*****:*:*******::*:****:***::**:*********.****:::**:::*:::*...**::*:**:****:*:*.*::****** |
---------------------------------------------------------------------------MSRNDQEPFFVKFLKSSDNSECFFKALESIKELQSEEYLQIITDEEALKIKENDKSLYICDRFSGTVFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDVTISCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAEPRAEAKTVPDTSTPTAQSNS--AESHTLADVSHISNINGSCVNETMFGSTTSKLECTLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDDVRQFWSKSSHRPHVVGAKWLLECFSKGYILPEESYIHANYQPAGIPVSDQPRNQTAVL-DKSGSFSKKDFVPAEKHQQADEDLLAQYENDDSTIVEAKLSEAIEPEVGPCNGSAHAEPCDDSTHISVQEENKSSVSHCILDDSTVREEGLFSQKSFLVLGFSVENECNIVNIIREHAGKIVSLPSRIVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSGMTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKSNAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFLVDNAPKQEQVLETNIPNGVSLNPDLPAHPDAHLEIHRKKAVTPLDMNRFQSKAFRAVISQHARQDAASPPVRQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAAS-QKRKLSSPLSEVIVRNLTLALANSSRNTDALSASPQLKGAHLEKEETPKPLDKVVVCVSKKLSKKQSELNGVAASLGAEYRWSFDETVTHFIYQGRANDSNREYKSAKERGVHIVSEHWLLECAQEYKHLPESLYPHTYNPKMSLDISTVQDGRLCNSRLPSAVSASKDDEPDHLSVEENATNTMGTNNKESALLNGSGRDDCKGALTQALEMRENFQKQLQEIMSATSIVKTPAQKTCMSRSSCNSASSTPDSTRSARSGRSRVLEALRQSRQAVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSDPTQYSELQVEIKNLDDSPSRKPVYHSEIAEQASC------VTQAPG-HPGSEEPEAPAAERNLIPEPQAPSVAFPLAKPPVAPQPADKIETQEETHRKLKKQYVFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACRTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAAMRWRKRIQQSQESGIVEGAFSGWKVILRVDRPREAGFKRLLQAGGAKVLPGHPEPLFKDATHLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMQESPPCADNYRVSEAALF--RNKEGGPGLPQKRKTPAE-NVIKRPRVH |