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FANCI human	MDQkILSLAAEkTADk K16-ac K16-ub LQEFLQTLREGDLTNLLQNQAVkGkVAGALLRAIFkGSPCSEEAGtLRRRKIYTCCIQLVESGDLQKEIASEIIGLLMLEAHHFPGPLLVELANEFISAVREGSLVNGkSLELLPIILTALATKkENLAYGkGVLsGEECkkQLINTLCSGRWDQQYVIQLTSMFKDVPLTAEEVEFVVEKALSMFSKMNLQEIPPLVyQLLVLSsKGSRKSVLEGIIAFFSALDKQHNEEQSGDELLDVVTVPSGELRHVEGTIILHIVFAIKLDYELGRELVKHLKVGQQGDSNNNLSPFSIALLLSVTRIQRFQDQVLDLLkTSVVkSFkDLQLLQGSkFLQNLVPHRSYVSTMILEVVKNSVHSWDHVTQGLVELGFILMDSYGPKKVLDGkTIEtsPsLsRMPNQHACkLGANILLETFkIHEMIRQEILEQVLNRVVTRASSPISHFLDLLSNIVMYAPLVLQSCSSKVTEAFDYLSFLPLQTVQRLLkAVQPLLKVSMSMRDCLILVLRkAMFANQLDARKSAVAGFLLLLKNFKVLGSLSSsQCsQSLSVsQVHVDVHSHYNSVANETFCLEIMDSLRRCLSQQADVRLMLyEGFyDVLRRNSQLANSVMQTLLSQLKQFYEPkPDLLPPLkLEACILtQGDKISLQEPLDYLLCCIQHCLAWYKNTVIPLQQGEEEEE--EEEAFYEDLDDILESITNRMIkSELEDFELDksADFsQsTSIGIKNNICAFLVMGVCEVLIEYNFSISSFSKNRFEDILSLFMCYKkLsDILNEkAGKAKTKMANktSDSLLSMKFVSSLLTALFRDSIQSHQESLSVLRSSNEFMRYAVNVALQkVQQLkETGHVSGPDGQNPEkIFQNLCDITRVLLWRYTSIPTSVEESGkKEKGksISLLCLEGLQKIFSAVQQFYQPkIQQFLRALDVTDkEGEEREDADVSVtQRTAFQIRQFQRSLLNLLSsQEEDFNSKEALLLVTVLTSLSKLLEPSsPQFVQMLSWTSKICkENSREDALFCKsLMNLLFSLHVSYkSPVILLRDLSQDIHGHLGDIDQDVEVEkTNHFAIVNLRTAAPTVCLLVLSQAEKVLEEVDWLITkLkGQVSQETLS-----EEAssQATLPNQPVEKAIIMQLGTLLTFFHELVQTALPSGSCVDTLLKDLCKMYTTLTALVRYYLQVCQSSGGIPKNMEkLVkLSGSHLTPLCYSFISYVQNKSkSLNYTGEkKEkPAAVAtAMARVLRETkPIPNLIFAIEQYEKFLIHLSKKSkVNLMQHMkLSTSRDFKIkGNILDMVLREDGEDENEEGTAsEHGGQNKEPAKKKRKK---
FANCI iso1 human	MDQKILSLAAEKTADKLQEFLQTLREGDLTNLLQNQAVKGKVAGALLRAIFKGSPCSEEAGTLRRRKIYTCCIQLVESGDLQKEIASEIIGLLMLEAHHFPGPLLVELANEFISAVREGSLVNGKSLELLPIILTALATKKENLAYGKGVLSGEECKKQLINTLCSGRWDQQYVIQLTSMFKDVPLTAEEVEFVVEKALSMFSKMNLQEIPPLVYQLLVLSSKGSRKSVLEGIIAFFSALDKQHNEEQSGDELLDVVTVPSGELRHVEGTIILHIVFAIKLDYELGRELVKHLKVGQQGDSNNNLSPFSIALLLSVTRIQRFQDQVLDLLKTSVVKSFKDLQLLQGSKFLQNLVPHRSYVSTMILEVVKNSVHSWDHVTQGLVELGFILMDSYGPKKVLDGKTIETSPSLSRMPNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTRASSPISHFLDLLSNIVMYAPLVLQSCSSKVTEAFDYLSFLPLQTVQRLLKAVQPLLKVSMSMRDCLILVLRKAMFANQLDARKSAVAGFLLLLKNFKVLGSLSSSQCSQSLSVSQVHVDVHSHYNSVANETFCLEIMDSLRRCLSQQADVRLMLYEGFYDVLRRNSQLANSVMQTLLSQLKQFYEPKPDLLPPLKLEACILTQGDKISLQEPLDYLLCCIQHCLAWYKNTVIPLQQGEEEEE--EEEAFYEDLDDILESITNRMIKSELEDFELDKSADFSQSTSIGIKNNICAFLVMGVCEVLIEYNFSISSFSKNRFEDILSLFMCYKKLSDILNEKAGKAKTKMANKTSDSLLSMKFVSSLLTALF------------------------------------------------------------RVLLWRYTSIPTSVEESGKKEKGKSISLLCLEGLQKIFSAVQQFYQPKIQQFLRALDVTDKEGEEREDADVSVTQRTAFQIRQFQRSLLNLLSSQEEDFNSKEALLLVTVLTSLSKLLEPSSPQFVQMLSWTSKICKENSREDALFCKSLMNLLFSLHVSYKSPVILLRDLSQDIHGHLGDIDQDVEVEKTNHFAIVNLRTAAPTVCLLVLSQAEKVLEEVDWLITKLKGQVSQETLS-----EEASSQATLPNQPVEKAIIMQLGTLLTFFHELVQTALPSGSCVDTLLKDLCKMYTTLTALVRYYLQVCQSSGGIPKNMEKLVKLSGSHLTPLCYSFISYVQNKSKSLNYTGEKKEKPAAVATAMARVLRETKPIPNLIFAIEQYEKFLIHLSKKSKVNLMQHMKLSTSRDFKIKGNILDMVLREDGEDENEEGTASEHGGQNKEPAKKKRKK---
FANCI mouse	MDLKILsLATDKTTDKLQEFLQTLKDDDLASLLQNQAVKGRAVGTLLRAVLKGSPCSEEDGALRRYKIYSCCIQLVESGDLQQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDRLVNGKSLELLPIILTALATKKEVLACGkGDLNGEEYkRQLIDTLCSVRWPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLTMFSKLNLQEIPPLVYQLLVLSSKGSRRSVLDGIIAFFRELDKQHREEQSSDELSELITAPADELYHVEGTVILHIVFAIKLDCELGRELLKHLKAGQQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKDLQLLQGSKFLQTLVPQRTCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSYGPKKILDGKAVEIGTSLSKMTNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLILQNC-SKVTETFDYLTFLPLQTVQGLLKAVQPLLKISMSMRDSLILVLRkAMFAsQLDARKSAVAGFLLLLKNFKVLGSLPSSQCTQSIGVTQVRVDVHSRYSAVANETFCLEIIDSLKRSLGQQADIRLMLYDGFYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGACVLTQGSQIFLQEPLDHLLSCIQHCLAWYKSRVVPLQQGDEGEE--EEEELYSELDDMLESITVRMIKSELEDFELDKSADFSQNTNVGIKNNICACLIMGVCEVLMEYNFSISNFSKSKFEEILSLFTCYKKFSDILSEKAGKGKAKMTSKVSDSLLSLKFVSDLLTALFRDSIQSHEESLSVLRSSGEFMHYAVNVTLQKIQQLIRTGHVSGPDGQNPDKIFQNLCDITRVLLWRYTSIPTSVEESGKKEKGKSISLLCLEGLQKTFSVVLQFYQPKVQQFLQALDVM---GTEEEEAGVTVTQRASFQIRQFQRSLLNLLSSEEDDFNSKEALLLIAVLSTLSRLLEPTSPQFVQMLSWTSKICKEYSQEDASFCKSLMNLFFSLHVLYKSPVTLLRDLSQDIHGQLGDIDQDVEIEKTDHFAVVNLRTAAPTVCLLVLSQAEKVLEEVDWLIAKIKGSANQETLSDKVTPEDASSQAVPPTLLIEKAIVMQLGTLVTFFHELVQTALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVCQSSRGIPNTVEKLVKLSGSHLTPVCYSFISYVQNKSSDAPKCSEKEK--AAVSTTMAKVLRETKPIPNLVFAIEQYEKFLIQLSKKSKVNLMQHMKLSTSRDFKIKGSVLDMVLREDEEDENEEGTASAHTQQDREPAKKRRKKCLS
FANCI rat	MDLKILSLATDKTTDKLQEFLQTLKADDLASLLESQAVKGRAVGTFLRAILKGSPCSEEDGALRRYKIYSCCIQLVESGDLQQDVASEIIGLLMLEVHHFPGPLLVDLANDFVGAVREDRLVNGKSLELLPIILTALATKKEGLTCGKGDLNGEECKRQLIDTLCSVRWAQRYVIQLTSVFKDVRLTPEEMKLVVAKVLTMFSRLNLQEIPPLVYQLLVLSSKGSRRSVLDGIIAFFRELDKQHSAEQSSDELSELVTAPADELHHVEGTIILHIVFAIKLDCELGRELLKHLKAGQQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDFLKTSVVKSFKDLQLLQGSKFLQTLVPQRTCVSTMILEVVKNSVHSWDHVTQGLIEFGFILMDSYGPKKILDGKAVEIGSSLSKMTNQHACKLGADILLETFKIHEMIRQEILEQVLNRVVTRTSSPISHFLDLFSDIIMYAPLILQSC-SKVTETFDYLSFLPLQTVQGLLKAVQPLLKISMSMRDSLILVLRKALFASQLDARKSAVAGFLLLLKNFKVLGSLPSSQCTQSIGVTQVHVDVHSRYSAVANETFCLEIIDSLKRCLGQQADVRLMLYEGFYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGACVLTQGSQTFLQEPLGHLLSCIQHCLAWYKSRVVPLQQGDEGEEEQEEEELYHELDDMLESITIRMIKSELEDFELDKSADFSQNNNVGIKNNICASLVMGVCEVLMEYNFSISNFSKSKSEEILSLFMCYKKFSDILSEKAGKGKAKMASKASDSLLSMKFVSDLLTALFRDSIQSHEESLSVLRSSSEFMHYALNVALQKVQQLTRTGCVSGPDGQNPDRIFQHLCDITRVLFWRYTSIPTSVEESAKKEKGKSISLLCLEALQKTFSAVLQFYQPKVQQFLQALDVM---STEEEEAGVTVTQRASFQIRQFQRSLLNLLSSQEEDFNSKEALLLVTVLSTLSKLLEPTSPQFVQMLSWTSKICKEHSQEDASFCKSLMSLFFSLHVLYKSPVTLLRDLSQDIHGQLGDIDQDVEIEKTDHFAIVNLRTAAPTVCLLVLSQAEKVLEEVDWLITKIKGSVNQETLSDEMTPEDASSQAVPPTVHIEKAITMQLGTLVTFFHELVQTALPSGSCVDTLLKDLSKIYSTLTAFVKYYLQVCQSSRRIPNTVEKLVKLSGSHLTPVCYSFISYVQNKSSNNPKCPEKEK--AAVSKSMAKVLRETKPIPNLVFAIEQYEKFLIQLSKKSKVNLMQHMKLSTSRDFKIKGNVLDMVLREEGEDENEEGTASAHTQQDREPAKKRRKKCLS
	**:******::**:**********:::**::**::*****:::*::***::********:*:***:***:************:::***********:*********:**::*::****::**********************.*::***:*:***:*:***:****:**:*:*:*****:****.**:**:.:**:*:*:***::*********************:***:******::*****.:***:***::::*:*::**.*****:***********:******:****:*****::::*:*********:******::**:*:**********************:***:*::*********:*************:*:************:****::*::.***:*:*********:***************************:****:*****:*:*:*****:**:*.*****:****:********:**********:******:********:**:*************************:****:**::*:**:*****:*::**********:***:*:*:****:*****:*************:*:****:*********:*********:**:****::::*****::**:**********::*:*****:*:**  ***::*.:***:*****.********************::::********.*:*******:*******:***:::*:*****:****:****:*****:*:**::*:******:****:******:::::::.:::::::::.:::.::.::.:::.:::..::.:::::::::..:::.:::::***:*************:**************:***:**:*:******:****:****:...::*:*:*:*:****::****************:*:**********::**::**:****:*****************.*:***:******:*:*****:*****:***********:*********:***:***:*****************************:*:**:::*****.....*:*****::*:..:****:******:**********************:*:*:*:****:*:*********::**:::*************:************:.::::.**::..***:::**:***********:***********:*************************::*******::**********:*::*::*****:***...
Consensus	MDQKILSLAADKTADKLQEFLQTLREDDLANLLQNQAVKGRAAGALLRAILKGSPCSEEAGALRRRKIYSCCIQLVESGDLQQDIASEIIGLLMLEAHHFPGPLLVDLANDFIGAVREDRLVNGKSLELLPIILTALATKKENLACGKGDLNGEECKRQLINTLCSGRWDQRYVIQLTSMFKDVPLTAEEMELVVAKALSMFSKLNLQEIPPLVYQLLVLSSKGSRRSVLDGIIAFFRALDKQHNEEQSGDELLDLVTAPADELRHVEGTIILHIVFAIKLDCELGRELLKHLKAGQQGDPNNNLCPFSIALLLSLTRIQRFQDQVLDLLKTSVVKSFKDLQLLQGSKFLQNLVPQRSCVSTMILEVVKNSVHSWDHVTQGLIELGFILMDSYGPKKILDGKAIEIGPSLSRMPNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTRASSPISHFLDLLSNIIMYAPLILQSCSSKVTEAFDYLSFLPLQTVQRLLKAVQPLLKISMSMRDCLILVLRKAMFANQLDARKSAVAGFLLLLKNFKVLGSLPSSQCSQSIGVSQVHVDVHSRYNAVANETFCLEIIDSLRRCLGQQADVRLMLYEGFYDVLRRNSQLANSIMQTLLSQLKQFYEPEPDLLPPLKLEACILTQGDQIFLQEPLDHLLCCIQHCLAWYKNRVIPLQQGDEEEE--EEEALYEDLDDILESITNRMIKSELEDFELDKSADFSQNTNIGIKNNICAFLVMGVCEVLIEYNFSISNFSKNRFEDILSLFMCYKKLSDILNEKAGKAKAKMANKTSDSLLSMKFVSDLLTALFRDSIQSHEESLSVLRSSNEFMHYAVNVALQKVQQLIRTGHVSGPDGQNPDKIFQNLCDITRVLLWRYTSIPTSVEESGKKEKGKSISLLCLEGLQKIFSAVQQFYQPKIQQFLRALDVMDKEGEEREDADVSVTQRAAFQIRQFQRSLLNLLSSQEEDFNSKEALLLVTVLSSLSKLLEPSSPQFVQMLSWTSKICKENSREDALFCKSLMNLLFSLHVLYKSPVILLRDLSQDIHGQLGDIDQDVEIEKTNHFAIVNLRTAAPTVCLLVLSQAEKVLEEVDWLITKIKGQVNQETLSD--TPEDASSQATLPNQPIEKAIIMQLGTLLTFFHELVQTALPSGSCVDTLLKDLCKIYSTLTALVRYYLQVCQSSRGIPNNMEKLVKLSGSHLTPLCYSFISYVQNKSKSLNKCGEKEEKPAAVATAMARVLRETKPIPNLIFAIEQYEKFLIQLSKKSKVNLMQHMKLSTSRDFKIKGNILDMVLREDGEDENEEGTASAHGQQNREPAKKRRKKCLS