Multiple Sequence Alignment:
COG6	Download MSA

	( 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 )
	\| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \|
COG6 human	MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHkILETRLDNDkEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFkEVKEELESISEDVQAMSNCCQDMTSRLQAAkEQTQDLIVk K135-ac K135-ub TTkLQSESQkLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFkALGRVkQIHNDVKVLLRTNQQTAGLEIMEQMALLQETAyERLYRWAQSECRTLTQESCDVSPVLTQAMEALQDRPVLYKYTLDEFGTARRs tVVRGFIDALtRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTTQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIVGNSATALLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLMLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASNLGTADMATFMVNSLYMMKTTLALFEFtDRRLEMLQFQIEAHLDTLINEQASYVLTRVGLSYIYNTVQQHKPEQGSLANMPNLDSVTLKAAMVQFDRYLSAPDNLLIPQLNFLLSATVKEQIVkQSTELVCRAYGEVYAAVMNPINEyKDPENILHRsPQQVQTLLS
COG6 mouse	MADASGEVAAVPASGAANGFSNGAGATPAQPNNPLSRKLHKILETRLENDKEMLEALKALSAFFVENSLRTRRNLRGDIERRSLAINEEFVNIFKDVKEELESINEDVQAMSSCCQDMTSRLQAAKEQTQDLIVKTTKLQAENQRLEIRAQVVDAFLAKFQLTSDEMSLLRGTRGGPVTEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETAYERLYRWAQSECRALTQESCDVSAVLSQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVKENIQEVVGHITEGVCRPLKVRIEQVILAEPGAVLLYKISNLLKFYHHTISGIVGNSAATLLTTIEEMHLLSKKIFFTSLSLHANKLMDKVELPPPDLGPSSALSQTLTLLRDILASHDSSVVPLDARQADFVQVLSCALDPLLQMCTVSASNLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRVGLSYIYNTIQQHRPDQGSLANMPNLDAVALKAAMAQFDRYLSAPDHLLMPQLNSLLSATVKEQIIKQSTELICRAYAEVHAAVMNPDNAYKDPENILHRSPEQVKTLLS
COG6 rat
	:::::**::*:::::************:*********:***************:*****::*****:***:************************:::****::************::*******************************************************:*****::***********************************************************************************::***********************:**************************::*************:**:***************::::********************:***************************************************************************:::**********::***:******::**:******:**:::*****::**********::****
Consensus	MADASGEVAAVPASGAANGLNNGAGATPAQPNNPLSRKLHKILETRLDNDKEMLEALKALSAFFVENSLRTRRNLRGDIERRSLAINEEFVNIFKDVKEELESINEDVQAMSNCCQDMTSRLQAAKEQTQDLIVKTTKLQAENQRLEIRAQVADAFLAKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETAYERLYRWAQSECRALTQESCDVSAVLSQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVEENIQEVVGHITEGVCRPLKVRIEQVILAEPGAVLLYKISNLLKFYHHTISGIVGNSAAALLTTIEEMHLLSKKIFFNSLSLHANKLMDKVELPPPDLGPSSALNQTLMLLRDILASHDSSVVPLDARQADFVQVLSCALDPLLQMCTVSASNLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRVGLSYIYNTIQQHRPDQGSLANMPNLDAVALKAAMAQFDRYLSAPDNLLIPQLNFLLSATVKEQIIKQSTELICRAYAEVHAAVMNPDNAYKDPENILHRSPQQVQTLLS

Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.

Aligned using MAFFT. Conservation and consensus calculated using von Neumann entropy from PFAAT.