Multiple Sequence Alignment:
HLAC Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400   )
           |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |   
HLAC human MRVMAPRALLLLLSGGLALTETWACSHSMRyFDTAVSRPGRGEPRFISVGyVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEyWDRETQkYkRQAQADrVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGkDyIALNEDLrSWTAADTAAQItQRkLEAARAAEQLRAyLEGTCVEWLRRyLENGkEtLQRAEPPkTHVtHHPLsDHEAtLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQkWAAVVVPsGQEQRYTCHMQHEGLQEPLTLSWEPSSQPT-----IPIMGIVAGLAVLVVLAVLGAVVTAMMCR-RKSSGGkGGsCSQAACsNs-AQGsDEsL----------ITCkA--------------------
HLAC iso2 human MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEHLRSCTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLRW----------------------------------------------GGKGGSCSQAACSNS-AQGSDESL----------ITCKA--------------------
HLAC iso5 human MRVMAPRtLLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPT-----IPIMGIVAGLAVLVVLAVLGAVVTAMMCR-RKSSGGKGGSCSQAACSNS-AQGSDESL----------ITCKA--------------------
HLAC iso6 human
HLAC iso7 human MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPT-----IPIMGIVAGLAVLVVLAVLGAVVTAMMCR-RKSSGGKGGSCSQAAsSNS-AQGSDESL----------ITCKA--------------------
HLAC mouse MGAMVPRTLLLLLAAALAPAQTRAGPHSLRYFETVVSRPGLGEPRFISVGYVDNTEFVRFDSDAENPRDEPRVRWMEQEGPEYWERETQIAKGNEQSFRVDLRTLLRYYNQSEGGSHTIQRLSGCDVGSDWRLLRGYEQFAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERDRAYLEGTCVEWLRRYLELGNATLLHTDSPKAHVTHHPRSKVEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQkWASVVVPLGKEQnYTCHVYHEGLPEPLTLRWEPPPSTDSYMVIVAVLGVLGAV------AIIGAVVAFVMMM-RRNTGGKGGDYTLTPG----SQSsEMsL--P--------DCKA--------------------
HLAC iso8 mouse
HLAC iso25 mouse ---MAPGKLLLLLAVALAPTQTRAGPHSLRYFYTTVSRPGLGEPRFISVGYVDNTEFVRFDSAAENPRDEPRVRWMEQEGPEYWERETQKSKGQKESFRVDLRTALRYYNQSKGGSHTLQVMYGCDVGSDWRLLRGYLQYAYDGRDYIALNEDLKTWTAADMAAQITRHKWEQAGAAELYKAYLEGECVEsLRRYLELGNATLLRTDSPKAHVTHHSRPKDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVYHEGLPEPLTLRWEPPPSTVSNTVIIAVLVVLGAA------IVTGAVVAFVMKMRRRNTGGkGGDyALAPG----SQtsDLsL--P--------DCKA--------------------
HLAC iso27 mouse ---MAPCTLLLLLAAALAPTQTRAGPHSLRYFETAVSRPGLGEPRYISVGYVDNTEFVRFDSDAENPRFEPRVRWMEQEGPEYWERETQRAKGQEQSFRVDLRTLLGYYnQSESGSHTLQVMYGCDVGSDWRLLRGYQQHAYDGRDYIALNEDLKTWTAADMAALITKQKWEQAGAAERLRAYLEGACVEWLRRYLERGnATLLRTDSPKAHVTHHPRSEDYVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAsVVVPRGKEQnYTCHVHHEGLPEPLTLRWEPPPSTDSYMVIIAVLGVLGAL------AIFGAVVAFVMRRRRRNTGGKGGDYTLAPG----SQSSDMSL--P--------DCKVMVDDPHSLA-----------
HLAC rat ------------------------GSHSLRYFVTAMSGPGLGKPRFMEVGYVDDTEFVRYDSDAKNPGMEPRARWMEREGREYWERETRIAKGNEQTFRENLRTLLRYYNQSEGGSHTFQWMSGCDVGSDGSLLRGYEQFAYDGRDYIVLNEDLKTWTAADTAARITRNKWDRAGVAERHKAYLEGKCLESLLRYLELGKETLLRSDPPKAHVTLHPRPEGDVTLRCWALGFYPAGISLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCLVEHEGLPEPLTQRWEPSPSTDSNMETYVIYVILGAVAIIAAV-IIVAVVAVVMK-RRRNTGGKVGVyAPAPSRDS-SESSDVSL--S--------DCKA--------------------
HLAC iso1 rat MGAMAPRTLLLILAAALAPtQTRAGSHsMRYFDIAVSRPGLGEPRFIIVGYVDDTEFVRFDSDAEKPRYEPRAPWMEPEGPEYWEEQTRRAKEGEQTFRVNLRTALHYYNQSEDRSHTIQRLSGCDVGSDGRLLRGYEQYAYDGRDYIALNEDLKTWTAADFAARISRNKWDQAGVAERLRAYLEGECVEWLRRYLELGKETLLRSDPPKAHVTLHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVEHEGLPEPLSQRWEPPPSTDSNMETTVIYVVLGAVAIIAAV-IIGAVVTVVRK-RRRNTGG-KGVYTPAPGTDS-SQSsDVsL--P--------DCKA--------------------
HLAC iso3 rat ---MAPRTLLLLLAAALAPTQTQAGSHSLRYFDIAVSRPGLGEPRFIIVGYVDDREVMRFDSDAENPRMKPRARWMEREGPEYWERQTRKVKEKEQIFRDNLRTLLRYYNQSEGGSHTVQRLSGCDVGSDGSLLRGYNQHAYDGRDyIALNEDLKtWTAADTAAQITKNKWERDGEAERRRAYLEGECVEWLRSYLAPRKETLLRSDPPKAHVTLHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMEFVETRPAGDGTFQKWASVVVPSGEEQNYTCLVEHEGLPKPLTQRWEPSPSTNTNMGIDVTSVVLGAVAVFVVLAIIGAVVCVVRRRRRRRNTGGKGDYTPARGRDS-SQSsDVsL--P--------DCKA--------------------
  ...:::::::::::::::::::.:::**:***.:::*:**:*:**:::*****:::::::**:*::*:.:**::*:*::::***:::*:::*:.::.:*:.**::::*****:::***:*:::***:*:*::*****.*.****:***:***:*:::****.**:*:..*::::::**:.:*****:*:*:*::**:.:::**:::::**:***:*::::..:************:*:****::**::***:*:***************:****:*:**:***::.*:**::**:::*::::::.......:..::::::......::.::::::::...::..:::::.::.:::... ::.*:.**  .       .:*::                    
Consensus MRVMAPRTLLLLLAGALALTQTWAGSHSMRYFDTAVSRPGLGEPRFISVGYVDDTEFVRFDSDAANPRGEPRAPWMEQEGPEYWERETQKYKRQAQADRVNLRTLLGYYNQSEDGSHTLQRMSGCDVGSDGRLLRGYDQSAYDGRDYIALNEDLKTWTAADTAAQITQRKWEAAGAAERLRAYLEGTCVEWLRRYLENGKETLLRADPPKAHVTHHPRSDHEATLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPSGKEQRYTCHVQHEGLPEPLTLRWEPSPSTTS----IPILGILGALAVLVVLAVLGAVVAAVMCR-RRNTGGKGGDYSQAPGSNS-SQGSDESL--P--------DCKA--------------------
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.