Multiple Sequence Alignment:
HMGCS1	Download MSA

	( 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520)
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HMGCS1 human	MPGsLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGk K46-ac K46-ub YTIGLGQAKMGFCTDREDINsLCMTVVQNLMERNNLSYDCIGRLEVGTEtIIDk sKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYk K206-ac K206-ub PDMLSEyPIVDGKLsIQCYLsALDRCYSVYCKk K239-ac K239-ub IHAQWQk K246-ac K246-ub EGNDKDFTLNDFGFMIFHSPYCKLVQk K273-ac K273-ub SLARMLLNDFLNDQNRDkNsIYsGLEAFGDVk K305-ub K305-sm LEDTyFDrDVEk K317-ac K317-ub AFMk K321-ac K321-ub ASSELFSQkTKASLLVSNQNGNMYTSSVYGSLASVLAQYsPQQLAGkRIGVFSYGSGLAATLYSLKVTQDATPGSALDkITASLCDLk K409-ac K409-ub K409-sc SRLDSRTGVAPDVFAENMkLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPtPNDDtLDEGVGLVHsNIATEHIPsPAk kVPRLPATAAEPEAAVIsNGEH
HMGCS1 mouse	MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGk K46-ac K46-ub YTIGLGQARMGFCTDREDINSLCLTVVQKLMERHSLSYDCIGRLEVGTETIIDk K100-ac K100-ub SKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWVESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFyk K206-ac K206-ub PDMLsEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQk K273-ub K273-sc SLARMFLNDFLNDQNRDkNSIYSGLEAFGDVKLEDTYFDRDVEk K317-ac K317-ub AFMkASSELFNQkTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRVGVFSYGSGLAATLYSLKVTQDATPGSALDkITASLCDLk K409-ac K409-ub SRLDSRTCVAPDVFAENMkLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARRPFTNDHSLDEGMGLVHsNTATEHIPsPAkKVPRLPATSAESESAVIsNGEH
HMGCS1 rat	MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGkYTIGLGQARMGFCTDREDINSLCLTVVQKLMERNSLSYDCIGRLEVGTETIIDkSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAIYASGNARPTGGVGAVALLIGPNAPVIFDRGLRGTHMQHAYDFYkPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARRPsTNDHSLDEGVGLVHSNTATEHIPsPAKKVPRLPATSGEPESAVIsNGEH
	****************************************************:**********::::********************:********************************:**************::*******************::**********************:*****************::****:*************************:****************************************::**************************************:******************************************:***************:*:***********************.:::**:**:***************::::*******
Consensus	MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARRPFTNDHSLDEGVGLVHSNTATEHIPSPAKKVPRLPATSAEPESAVISNGEH

Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.

Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.