Multiple Sequence Alignment:
SFR1	Download MSA

	( 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 )
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SFR1 human	--------------------------------------------------------------MAEGEKNQDFTFKMESPSDS----------------------------------------------------------------------------------------AVVLPSTPQASANPSSPYTNSSRkQPMsAtLRERLRKTRFsFNs sYNVVKRLKVESEENDQTFSEKPASSTEENCLEFQESFKHIDsEFEENTNLkNTLKNLNVCESQSLDSGSCSALQNEFVSEKLPKQRLNAEKAKLVKQVQEkEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAVSE-ENk kLSLTQLIDHYGLDDKLLHYNRSEEEFIDV
SFR1 iso2 human	MKNLVVPMWEGkWKTAkRARMNyKVKLEEISGLLVDALYTNTIYYLIKVDYREVWLIRLFYNFSFLEKNQDFTFKMESPSDS----------------------------------------------------------------------------------------AVVLPSTPQASANPSSPYTNSSRKQPMSATLRERLRKTRFsFNSSYNVVKRLKVESEENDQTFSEKPASSTEENCLEFQESFKHIDSEFEENTNLkNTLKNLNVCESQSLDSGSCSALQNEFVSEKLPKQRLNAEKAKLVKQVQEKEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAVSE-ENkKLSLTQLIDHYGLDDKLLHYNRSEEEFIDV
SFR1 mouse	---------------------------------------------------------------MAEEGNQEFTSKMENSSDSASTSPDAPQPSENPPSPPTSPAAPQTSENPPSPPTSPAVPQTRENPPsPPt sPAAPQPRENPPsPPt --------SPAAPQPRENPPsPPt sPAAPQPRENPPsPHsNSsGKQPLsGtPKERLKKARs s sHsFCsVVkRMKVENDENNEtLsEPGEs sKEENCsKAQESLKNKDSEPGEK-----SSEEKNTCESKSSDTGSSNALPKESE-NAIIREKLKQEKIRLIRQVEEKEDLLRRLKLVKMYRIkNDVTELENLIKKWRKCGQRLLCELQSIMSEDEDEKLTLTELIDFYGIDDNLLHYNRSEEEFTGV
SFR1 rat	---------------------------------------------------------------------------------------------------------------------------------------MASAPSDIPENAFRLAKASGRCQSMMSQMKDETK----CMGAVFSGYPTALWLEYEVSPQPMSGTLKERLKKARASSQPFCSVVkRIKVENEENDQTLSEPGESSKEENCSKAQESLENKDNEPEKE-----SSEDKNTSESKSLDTGSSSVLQKDST-EkTIKQTLkEEKAKLTRQVQEKEDLLRRLKLVKMYRIKNDVTELEDLIKKWRRCGQRLLCELQSIMSEDEDEKLTLTELIDYYGIDDKLLHYNRTEEEFTGV
	....:.::.::.:::..::: .............. ............ ....::::::.::::::..:::.:*::::*::::.::::**::::::::::**:::::::::::......:::.:::*::::::::::..::.:::.:::::::************:::::.*****.:::*::.::::.::**:*::
Consensus	---------------------------------------------------------------AAEEKNQDFTFKMESPSDS------------------------------------------------------A--P---P------------------Q-------AVVLPSAPQASANPSSPYTNSSRKQPMSATLRERLRKARFSFNSFCNVVKRLKVENEENDQTLSEKGASSKEENCLEAQESLKNIDSEFEENTNLKNSLENLNTCESQSLDSGSCSALQNEFVSEKLIKQRLNAEKAKLVRQVQEKEDLLRRLKLVKMYRIKNDLSQLQLLIKKWRSCGQRLLCELQSAMSEDENEKLSLTQLIDHYGIDDKLLHYNRSEEEFIDV

Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.

Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.