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PLEKHG6 human	MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGyPVLDPsRRRLQQyVPFArGSGQArGLsPMRLRDPEPEKRHGGHVGAGLLHsPKLKELTKAHELEVRLHtFsMFGMPRLPPEDRRHWEIGEGGDsGLtIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIyVRKLKIMtDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRsGRQMLCDLLIKPHQRITKyPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPStRPstP--SLEGSQSSAEGRTPEFSTIIPHLVVTEDtDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLtFSTLELRDIPLRPHPPDPQAPQRRsAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSsPTHADSAGESPWESSGEEEEEGPLFLKAGHTsLRPMRAEDMLREIREELASQRIEGAEEP--RDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV
PLEKHG6 iso2 human	----------------------MG----------CRLHAPGEKAAHDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTP--SLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEP--RDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV
PLEKHG6 mouse	MQAFGPPNEGPLQGLVASRIETYGGRHQTSAHsTAGNLFPRGGPGVDPSRRRLQHYVPFAKGSGQTRGMSPLVLREPDPEKRHGSYFGVGPPHSPKLKEVTRAHELEIRLHTFSMFGMPRLPPEDRRHWEIGEGGDSALTMEKSWKELVLEHKEMNRQLCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLTEVSAETLFGNVPNLIRAHRRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQRFQPYVQYCLRVKQTMAYAREQQDTNPLFHTFVQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVRKRSPEPRAQEALNAMIEAVESFLRHINGQVRQGEEQESLMAVAQRIGPYEVLEPSSEEVEKNLRPFSTLDLMTPVLGVAPEYTRQLLLEGPVRVKEGREGKMDVYLFLFSDVLLVTKPQRKADRAKVIRPPLMLEKLVCRPLRDPNSFLLIHLTEFQCVSSALTVHCPSSTERARWLEKTQHAQTTLQKLKGEQYIQQKRELLALYRNQGTEsPSTRPSTPSPSPEDSQSSAEGRTLEFA-IIPRLVVTEDTDEDTPSMPDDASDSGYGTLIPSSPKDSHsPLNRLRSKALRRDPRLTFSTLELRDVPLRPQPPDPQAPQRRSAPELPEGILRGGSLPRRAPPIWSEEEDETLASGNVVVETLHRAQRRSPLPHSPTHTDSAGESPWESSDEDE--GLLSP---ELRPRSLR-EDMLREIREELANQRIDGASEPEPGNGKPRRLTLAQLQRMRVPHIIQLDTPLSTSEV
PLEKHG6 rat	MQTFDPPNEGPLQGLVASRIETYGGRHQTSAQSSAGITYPRGGPALDLSRRRLQHYVPFAKGSGQTRGLSP---QEPDPEKRHGNYFGVGSPYFPKFKEVSKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSALTIEKSWKELVLGHKEMNRELCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLTEVSAETLFGNVPKLIRTHRRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQRFQPYIQYCLRVKQTMAYAREQQDTNPLFRTFVQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVLKRSPEPRAQLALDNMIVAVESFLQHINGLVRRGEEQESLMAVAQRIGPYEVLEPSSEEVEKHLRQFSTLDLMTPIEGVAPENTRQLLLEGPVRMKEGREGKMDVYLFLFSDVLLVTKPQRKVDKAKVIRPPLMLEKLVCRPLRDPHSFLLIHLTEFQCVSSALTVHCSSSTERTQWLQKTQQAQATLQKLKAEEYVQQKRGLLALYRDQGRESPSPRPSTP--SPEDSQSSAEGRALEFT-VIPRLVVTEDTDEDTPSVTDDTSDSGYGTLIPSSPKDSQSPLNRLRSKALRRDPRLTFSTLELRDVPLRPQPPDPQALQRRSAPEMPEGILRGGsLPRRAPPTWSEEEDETLTPGNVVVETLSRAQRRSPLPHSPAHTDSAGESPWESTDEDE--GPLSP---GLRPRSLRAEDMLREIREELASQRIEGALEPEPGNGKLRRLTRAQLQRMRGHHVIQLDTPMSTSDV
	:..:.::.:::::::::::::::*:::.:::.:.::..:*::.::.*:******:*****:****:**:**..:::*:******.::*:*.:::**:**:::*****:*****************************:**:****:***::****:::******************:***********************:************.***:**:**:***:*:**:**:*******::**:*********:**:*****************:*****::**************:*:*****************:**:*****:***:**::**:******:****:**:*******:*:************:*:****:**:******::*.:***:*.***********:*******:*******************:*:***************:*****:*****************:***:*:*:*::**:***:**::*****:*:*:****:**:***:*::****:*****  *:*:********::**:.:**:**********:*:::**:**********::*::*.***:***::*****************:****:******:*******:*****:*****:::**:******::::.********:**::*::**:**:*:**********::*:*..*:*::....:::*::*:************:***:**.**..:::::*:**:*******::*:******:*:*:*
Consensus	MQAFGPPNEGPLQGLVASRIETYGGRHQTSAQSTAGRLYPRGGPALDPSRRRLQQYVPFARGSGQARGLSPMRLRDPDPEKRHGGHFGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSALTIEKSWRELVLGHKEMNRELCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRRFWDEVLQPILEDTRASGQPLDPIGLQNGFLTFGQRFQPYVQYCLRVKQTMAYAREQQDTNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLQAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLMSPMLGVAPEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCRPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLALYRDQDRESPSTRPSTP--SLEDSQSSAEGRTLEFSTIIPRLVVTEDTDEDAPLVPDDTSDSGYGTLIPGSPKDSRSPLNRLRQRALRRDPRLTFSTLELRDIPLRPQPPDPQAPQRRSAPELPEGILRGGSLPRRAPPTWSEEEDEALERGNVVVETLHRARRRGQLPHSPTHADSAGESPWESSDEDEEEGPLFLKAGHLRLRPLRAEDMLREIREELASQRIEGAEEPEPRNGRPRRLTRAQLQRMRGPHIIQLDTPLSASEV