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pyrin human	MAKTPsDHLLstLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTYYGEEYAVQLTLQVLRAINQRLLAEELHRAAIQEYSTQENGTDDSAASSSLGENKPRSLKTPDHPEGNEGNGPRPYGGGAAsLRCSQPEAGrGLSRKPLSKRR-EKASEGLDAQGKPRtRSPA-----LPGGRsPGPCRALEGGQAEVRLRRNAssAGRLQGLAGGAPGQKECRPFE--VYLPSGKMRPRsLEVTISTGEKAPANPEILLTLEEKtAANLDsATEPRA--------------R-PTPDGGASADLKEGPGNPEHSVT-------------------------------------------------------------------------------GRPPDTAASPRCHAQEGDPVDGTCVRDSCSFPEAVSGHPQASGSRSPGCPRCQDSHERKsPGSLsPQPLPQCKRHLkQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKKKIQKQLEHLkkLRKSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHFFVASLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKWTTPQEIKQKIQLLHQKSEFVEKSTKYFSETLRSEMEM--FNVPELIGAQAHAVN-------VILDAETAYP---NLIFSDDLKSVRLGNKWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGDKTAWILGACKtsISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIFVDYRVGSISFyNVTARSHIyTFASCSFSGPLQPIFSPGTRDGGKNTAPLTICP-----VGGQGPD------
pyrin mouse	MAKTLGDHLLNTLEELLPYDFEKFKFKLQNTSLEKGHSKIPRGHMQMARPVKLASLLITYYGEEYAVRLTLQILRATNQRQLAEELRKATGTEHLIEENRVGGSVQSSV--ENKAKSVKVPDVP---EGDGTQQNNDESDTLPSSQAEVGKGPQKKSLTKRKDQRGPESLDSQTKPWTRSTAPLYRRTQGTQsPGD----KESTASAQLRRNVsSAGRLQGLYNNAPGRREsKKAEVYVYLPSGKKRPRsLEITTYSREGEPPNSEVLPTQEETRNGSL-----IRM--------------RTATLNGRTTGALEKGTGIPEHSMVLDEKTFRNMSSKTsLIGEERCPTSWTENGNGSPETTESSGETAGSILSD---PEVPLSLCEKPAKTPEDPASLGQAACEGRSQDKAVCPLCHTQEGDLRGDTCVQSSCSCSIA-PGDPKASG-RCSICFQCQGLLARKsCEAQsPQSLPQCPRHMKQVLLLFCEDHREPICLICRLSLEHQGHRVRPIEEAALEYKEQIREQLERLREMRGYVEEHRLQGDKKTDDFLKQTEIQKQKISCPLEKLYQLLEKQEQLFVTWLQELSQtISKVRETYYTRVS----LLDEMIEELEAKQDQPEWDLMQDIGITLHRAKMMSASELLDTPPGVKEKLHLLYQKSKSVEKNMQCFsEMLssEMAFSASDVAKWEGRQPSATQVQGLVPTVHLKCDGAHTQDCDVVFYPEREAG--GSE-------PKDY---------------------------------------------LHPQ--------------PAQDTP------------------------ELHEIHSRNNKRKFKSFL---KWKPSFS-------RTDWRLRTCCYRDLDQAAAHPNLIFSMI
pyrin rat	MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSLVKMARPIKLTRLLLTYYGEEYAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVGGSVQSSA--ENKDKGVKGSDVP---GEDEAQQNDDESDILPPIQAEVGKGPQKKSLAKRKDQRGPESLDSQTKPGARSAAPLYRRTLVTQSPGD----KENRAGAQPQEC-----------------QLCREAARSTAMSQGGERSRRLKCICL-QERSDPGVLKLPLTQKkENPQI-----QKLFRLKRKQEMAVSFVREATLNGRTTGTLEKGVGIPEHSMMLDEETSRNMSSKISLTREKRCTASWTENGNGGPETPETLGETVSSILCDSCSPKVLLSLGEKLAQTPEDPASLGQAASKGRSRDKVACPLCHTQ-GELPAKACVQSSCSCSVA-PGDPKASG-RHSICFQCQSSRAGKSCEAQSPQFLPQCPRHMKQVQLLFCEDHREPICLICRLSQEHQGHRVRPIEEAALQYKEQIRKQLERLREMRGYVEEHKLPADKKAEDFLKQTETQKQRISCPLEKLFQFLEQQEQLFVTWLQELVQTIGKVRETYYTQVS----LLDKLIGELEAKQDQPEWELMQDIGATLHRAETMTASELLGIPPGVKEKLHLLYQKSKSAEKNMQRFSEMLGSEMAFSASDVATREGCRPSTTKAQALIPTVHLKCDGAHTQDFDVILCAELEAG--GSE-------PQDY---------------------------------------------LHPS--------------SAQDTP------------------------ELHEIHSQNNKRKFKSFL---KWKPSFS-------RTDRCLRTCW------------------
	**:*..****:*****:**::*******::**::*:**:**::..::***:*::.**.*********:****:***:***:*****::*::.*::::**::::*::**:..***::::*.:*:*...::::::::.::::.*:.:*:*:*:*:::*:*:**::::::*:**:*:**.:**:*::::::.:::***:....::..*.::::::.:::::::::...:::..:::.::..:::::*:.*:*:*:.:....*.::::.:.*::.:::.::.:......::..............*.:*::*:::::*::*.*:****:.:::.:.::::::.::..:.::..::::::::.:::.:..:::..:::.:...:.:.:::.::.:.::::::::::::..**:.*::::*:**:*:*::.:.:**::***::.*.:*:*:***.*.::*::**.:.::**::::***.****:**:***:*******:*******:**:************:**::*::*::***:*:::*:::**:::.:::*:.:******::**:::::**:::::**:**::**::*:::.*:::::*::*:*:**....***::*:*****::*:**:*:****::****:::.::*::.:*:::*:*::**:***:::**:::.***:*.***::::::*:..:*::::::..:.:.::*:*::::*::::.::::.::::::..*::.......*:::.............................................*:*................*:::*........................:::::::::::::*:*::...:::*:**.......::::.*::*...........:.......
Consensus	MAKTRGDHLLNTLEELLPYDFEKFKFKLQNTSLEKGHSRIPRSQIQMARPVKLARLLITYYGEEYAVRLTLQILRATNQRQLAEELHKATGQEHLTEENGVGGSVQSSA--ENKAKSVKGPDVP---EGDGAQQNNDESDILPCSQAEVGKGPQKKSLAKRKDQRGPESLDSQTKPRTRSAAPLYRRTQGTQSPGD----KENRAEAQLRRNASSAGRLQGLANNAPGRRECREAERSVYLPSGKERPRSLECTCLSRERAPPNPEILPTQEEKRNANL-----QRA--------------REATLNGRTTGALEKGPGIPEHSMMLDEETFRNMSSKISLIREERCPASWTENGNGGPETPESLGETAGSILCD---PEVLLSLCEKLAQTPEDPASLGQAACEGRSRDKAACPLCHTQEGDLRADTCVQSSCSCSEA-PGDPKASG-RCSICFQCQDSRARKSCEAQSPQFLPQCPRHMKQVQLLFCEDHREPICLICRLSQEHQGHRVRPIEEAALEYKEQIRKQLERLREMRGYVEEHRLQGDKKADDFLKQTEAQKQRISCPLEKLYQFLEQQEQLFVTWLQELGQTIGKVRETYYTRVS----LLDALIGELEAKQDQPEWELMQDIGATLHRAKTMPASELLDTPPGVKEKLHLLYQKSKSVEKNMQRFSEMLRSEMAFSASDVAEREGAQPSATNAQALIPTVHLKCDGAHTQDCDVIFCAELEAG--GSE-------PQDY---------------------------------------------LHPQ--------------QAQDTP------------------------ELHEIHSRNNKRKFKSFL---KWKPSFS-------RTDARLRTCC-----QAAAGPN------