(        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670       680       690       700       710       720       730       740       750       760       770       780       790       800       810       820       830       840       850       860       870    )
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Alix human	MATFISVQLkKTsEVDLAkPLVk K23-ac K23-ub FIQQTYPSGGEEQAQyCRAAEELSk K48-ac K48-ub LRRAAVGRPLDk K60-ac K60-ub HEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDkGsLFGGsVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKEtVLsALSREPTVDISPDTVGtLSLIMLAQAQEVFFLKATRDKMkDAIIAk K215-ac K215-ub LANQAADyFGDAFkQCQYkDTLPk-----EVFPVLAAKHCIMQANAEyHQSILAKQQKk K269-ac K269-ub FGEEIARLQHAAELIkTVASRYDEyVNVkDFSDkINRALAAAKkDNDFIyHDrVPDLkDLDPIGkATLVkSTPVNVPISQk K350-ac K350-ub FTDLFEkMVPVSVQQsLAAyNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSRSVIEQGGIQTVDQLIkELPELLQRNREILDESLrLLDEEEAtDNDLRAkFKERWQRtPsNELyk K486-ac K486-ub K486-sc PLRAEGTNFRTVLDkAVQADGQVkECYQSHRDTIVLLCKPEPELNAAIPSANPAkTMQGSEVVNVLKSLLSNLDEVkKEREGLENDLKsVNFDMTSKFLTALAQDGVINEEALSVTELDrVyGGLttkVQESLKKQEGLLkNIQVSHQEFSkMkQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCsDIVFARKTERDELLkDLQQsIAREPsAPsIPtPAyQssPAGGHAPtPPtPAPrTMPPTk K751-ac K751-m1 K751-ub PQPPArPPPPVLPANrAP-SATAPSPVGAGTAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ
Alix iso2 human	MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKYFYFQEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAP-SATAPSPVGAGTAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ
Alix mouse	MASFIWVQLKKTSEVDLAk K19-ac K19-ub PLVKFIQQTYPSGGEEQAQYCRAAEELSk K48-ac K48-ub LRRSALGRPLDkHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDk K101-ac K101-ub GSLFGGsVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKTAAKQYQFASGAFLHIKDTVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAkLANQAADYFGDAFKQCQYKDTLPK-----EVFPTLAAKQCIMQANAEYHQSILAKQQkkFGEEIARLQHAAELIkNVASRYDEYVNVk K298-ac K298-ub K298-sc DFSDKINRALTAAKKDNDFIYHDRVPDLKDLDPIGKATLVKPTPVNVPVSQkFTDLFEKMVPVSVQQSLAVFSQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSTSVVEQGGIQTVDQLIKELPELLQRNREILEESLRLLDEEEATDNDLRAKFKDRWQRTPSNDLYkPLRAEGAKFRAVLDkAVQADGQVKERYQSHRDTIALLCKPEPELNAAIPSANPAKTMQGSEVVSVLKSLLSNLDEIKKERESLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRIYGGLTSKVQESLKKQEGLLkNIQVSHQEFSkMkQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLkDLQQSIAREPsAPSIPPPAyQSSPAAGHAAAPPtPAPRTMPPAKPQPPARPPPPVLPANRVPPASAAAAPAGVGTASAAPPQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPTYPFPQPPQQSYYPQQ
Alix rat	MASFIWVQLKKTSEVDLAkPLVKFIQQTYPSGGEEQAQYCRAAEELSkLRRSALGRPLDkHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKTAAKQYQFASGAFLHIKDTVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAkLANQAADYFGDAFKQCQYKDALPKYFYFQEVFPTLAAKQCIMQANAEYHQSILAKQQKkFGEEIARLQHAAELIKNVASRYDEYVNVkDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVkPTPVNVPISQKFTDLFEKMVPVSVQQSLAVFSQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSTAVVEQGGIQTVDQLIKELPELLQRNREILEESLRLLDEEEATDNDLRAKFKDRWQRTPSNDLYkPLRAEGAKFRAVLDKAVQADGQVKERYQSHRDTIALLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEIKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRIYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNSEASLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQsIAREPSAPSIPPPAYQSSPAGGHATAP-TPAPrTMPPAKPQPPARPPPPVLPANRVPPAAAATAPAGVGTASAAPPQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYTYGQYNMPYPPVYHQSPGQAPYPGPQQPTYPFPQPPQQSYYPQQ
	**:**:*********************************************:*:*********************************************************************************************:***:************:**********************************************************************:***.....****:****:************************************:**********************:******************************:******:*********************:::**************************************************::*:**************************:*********************:********:*********::**:**************:********:****************************:***********:*****:**************************************:*****:******************************:**:****************************************************************************:********:***::*:*********:*****************:*.:::*::*:*:***::**:*************************************:***************************:***************
Consensus	MASFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAALGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKQYQFASGAFLHIKDTVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKYFYFQEVFPTLAAKQCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKNVASRYDEYVNVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKPTPVNVPISQKFTDLFEKMVPVSVQQSLAAFNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKDRWQRTPSNDLYKPLRAEGANFRAVLDKAVQADGQVKERYQSHRDTIALLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEIKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRIYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPPPAYQSSPAGGHAPAPPTPAPRTMPPAKPQPPARPPPPVLPANRAPPAAAAPAPAGAGTAAAAPPQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ