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EPS15 human	MAAAAQLsLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDtssPLLISGTSAAELPWAVKPEDKAKYDAIFDSLsPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVsPAEKAk K227-m1 K227-ub YDEIFLk K234-m1 K234-ub TDKDMDGFVsGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLtPEMIPPSDRAsLQkNIIGssPVADFSAIkELDTLNNEIVDLQREKNNVEQDLkEkEDTIKQRTSEVQDLQDEVQRENTNLQkLQAQkQQVQELLDELDEQKAQLEEQLkEVRKKCAEEAQLISSLKAELTsQESQISTyEEELAkAREELsRLQQETAELEEsVEsGkAQLEPLQQHLQDsQQEISSMQMkLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLEsEPIHQEsPARssPELLPSGVTDENE-VTTAVTEKVCsELDNNRHsKEEDPFNVDssSLTGPVADTNLDFFQSDPFVGSDPFkDDPFGkIDPFGGDPFkGSDPFAsDCFFRQ-StDPFATSSTDPFSAANNssITSVETLKHNDPFAPGGTVV-AASDSATDPFASVFGNEsFGGGFADFSTLSKVNNEDPFRsATSSsVSNVVITkNVFEETSVkSEDEPPALPPkIGtPtRPCPLPPGk K788-ac K788-ub RsINkLDsPDPFkLNDPFQPFPGNDsPkEkDPEIFCDPFTSATTTTNkEADPSNFANFSAyPsEEDMIEWAkRESEREEEQRLARLNQQEQEDLELAIALSkSEISEA
EPS15 mouse	MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLSKQEFFVALRLVACAQNGLEVSLSSLSLAVPPPRFHDsssPLLTsGPSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVsPAEKAkYDEIFLKTDKDMDGyVSGLEVRETFLKTGLPSALLAHIWSLCDTKGCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNItGSsPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTVKQRTSEVQDLQDEVQRESINLQkLQAQKQQVQELLGELDEQKAQLEEQLQEVRKKCAEEAQLISSLKAEITSQESQISSYEEELLkAREELSRLQQETAQLEESVESGkAQLEPLQQHLQESQQEISSMQMRL-EMKDLETDNNQSNWSSSPQSVLVNGATDYCSLSTSSSETANFNEHAEGQNNLESEPTHQESSVRssPEIAPSDVTDESEAVTVAGNEKVTPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGkIDPFGGDPFkGSDPFASDCFFKQTSTDPFTTSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVVAAASDSATDPFASVFGNESFGDGFADFSTLSKVNNEDAFNPTISSSTSSVTIAKPMLEETAsKSEDVPPALPPKVGtPtRPCPPPPGKRPINkLDssDPLkLNDPFQPFPGNDsPkEkDPDMFCDPFTSSTTT-NKEADPSNFANFSAyPsEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
EPS15 rat	MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVACAQNGLEVSLSSLNLAVPPPRFHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAkYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNTIGSsPVADFSAIKELDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQDEVQRESLNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRL-AMKDLETDNNQSNWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRssPEIAPSDVTDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVV-AATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPFNPTISSSASSVVIPKPVLEETPSKSEDVPPALPPKTGTPTRPCPPPPGKRPINKLDssDPFKLNDPFQPFPGNDsPKEKDPDMFCDPFTSSSTTANKEAEPSNFANFSAYPsEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
	**************************::********:*****************************:*:*****:*******************:**********:*****:**:*:********:****************:*******************:***************:**************************************************************:********:********:******:*****.****************:***********:***********:*****::*********************:*******************::***:*:**********:.****************:*************:*******************:********:*****:**************:********************:**********:*.:*****::*:*:**:***:*:*****:**************:***:***:******:*:**::*****::**:****:*.**:*..***.:::*:::**********:*****::************************************************:*:*****:*********::***:*****:*************.**:*****************:***********:***:*::::***:*:*:*:*:::***::****:*******.********:*****:******:**:********************::*******::**.****:*********************************************************
Consensus	MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWSLCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTVKQRTSEVQDLQDEVQRESINLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELAKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRL-EMKDLETDNNQSNWCSSPQSILVNGATDYCSLSTSSSETANLNEHAEGQNNLESEPIHQESSVRSSPEIAPSDVTDESEAVTAADNEKVCPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVV-AASDSATDPFASVFGNESFGDGFADFSTLSKVNNEDPFNPTISSSASSVVIAKPVLEETASKSEDVPPALPPKIGTPTRPCPPPPGKRPINKLDSSDPFKLNDPFQPFPGNDSPKEKDPDMFCDPFTSSTTTANKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA