Multiple Sequence Alignment:
Abi-1 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520     )
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Abi-1 human MAELQMLLEEEIPSGKRALIESyQNLTRVADYCENNyIQ-----------------ATDkRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMEsSINHISQTVDIHKEKVARREIGILTTNKNTSRTHkIIAPANMERPVRYIRkPIDyTVLDDVGHGVKWLKAKHGNNQPARtGtLSRtNPPtQKPPsPPMsGRGtLGRNtPyKtLEPVKPPtVPNDyMtsPARLGsQHsPGRtAsLNQRPRtHsGssGGsGsRENsGSSSIGIPIAVPtPsPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVIAAPGSAPGSQYGTMTRQIsRHNsttsstssGGyRRtPsVTAQFSAQPHVNGGPLySQNSIsIAPPPPPMPQLTPQIPLTGFVARVQENIADsPtPPPPPPPDDIPMFDDsPPPPPPPPVDyEDEEAAVVQyNDPyADGDPAWAPKNYIEKVVAIyDYtKDKDDELSFMEGAIIYVIKKNDDGWyEGVCNRVTGLFPGNyVEsIMHytD
Abi-1 iso2 human MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQ-----------------ATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGV-----KHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGsGSRENSGSSSIGIPIAVPTPSPPTIGP----------------------------APGSAPGsQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI-----------------------------ADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD
Abi-1 iso3 human MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQ-----------------ATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRtHsGsSGGSGsRENsGssSIGIPIAVPtPsPPtIGPA---------------------------APGsAPGsQyGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI-----------------------------ADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD
Abi-1 iso11 human MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQ-----------------ATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHIS----------------------------------------------------------------QHGNNQPARtGtLsRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPV-------------------------------------------------------------------------------------------------------------------ADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD
Abi-1 iso12 human MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQRHGFAVLLCLLSNSWPQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI-----------------------------ADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD
Abi-1 mouse MAELQMLLEEEIPSGKRALIESyQNLTRVADYCENNYIQ-----------------ATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMEsSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVkWLKAKHGNNQPARTGtLsRtNPPtQKPPsPPVsGRGtLGRNtPyktLEPVkPPTVPNDyMtsPARLGsQHsPGRtAsLNQRPRTHsGSsGGSGSRENSGSSSIGIPIAVPTPSPPTAGPA---------------------------APGAAPGSQYGTMTRQIsRHNsttSsTSSGGyRRTPSVAAQFSAQPHVNGGPLYSQNSISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQySDPYADGDPAWAPKNYIEKVVAIyDYTKDKDDELsFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHytD
Abi-1 iso4 mouse MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQ-----------------ATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGV-----KHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHsGsSGGSGsRENsGsSSIGIPIAVPTPSPPtAGP----------------------------APGAAPGSQyGTMTRQISRHNSTTSSTSSGGYRRTPSVAAQFSAQPHVNGGPLYSQNSISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
Abi-1 rat MAELQMLLEEEIPSGKRALIESyQNLTRVADYCENNYIQ-----------------ATDKRkALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGV-----KHGNNQPARTGTLSRTNPPTQKPPsPPVSGRGTLGRNTPyKTLEPVkPPTVPNDyMtSPARLGsQHsPGRTAsLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPA---------------------------APGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELsFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
  ***************************************                 *******************************************************:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.....:**************************:************************************************************************************:**.                           :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.............................******************************************:***********************************:***************:************************
Consensus MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQ-----------------ATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPA---------------------------APGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIS-APPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.