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HEFL human	MKGtGIMDCAPKALLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETyQVPTLPRPPtPGPVyEQMRsWAEGPQPPtAQVyEFPDPPTSARIICEKTLsFPKQAILtLPRPVRAsLPTLPsQVyDVPtQHRGPVVLKEPEKQQLyDIPAsPKKAGLHPPDSQASGQGVPLISVTTL-RRGGystLPNPQKSEWIyDtPVsPGKASVRNTPLTSFAEESRPHALPsSSSTFyNPPSGRSRsLtPQLNNNVPMQKKLsLPEIPsyGFLVPRG-TFPLDEDVsyKVPSSFLIPRVEQQNtKPNIyDIPKATSSV-----------SQAGKELEKAKEVSENsAGHNSSWFSRRtTsPSPEPDRLSGsSSDSRASIVSSCsTTStDDsSSSSSEESAKELsLDLDVAKETVMALQHKVVSSVAGLMLFVsRKWRFRDYLEANIDAIHRSTDHIEESVREFLDFARGVHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDLERFVMVARMLPEDIKRFASIVIANGRLLFKRNCEKEEtVQLTPNAEFKCEKYIQPPQRETESHQ-KSTPSTKQREDEHSSELLKKNRANICGQN--------------------------PGPLIPQPSSQQTPERKPRLSEHCRLyFGALFKAISAFHGSLSSSQPAE-IITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQAEAEKLEQHTRQFRGTLG
HEFL iso3 human	MKGTGIMDCAPKALLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTPGPVYEQMRSWAEGPQPPTAQVYEFPDPPTSARIICEKTLSFPKQAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDsQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SN--------------------------PGPLIPQPSSQQTPERKPRLSEHCRLYFGALFKAISAFHGSLSSSQPAE-IITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQAEAEKLEQHTRQFRGTLG
HEFL mouse	MRGTSIREGAPKTLLARALYDNHADCSDELAFSRGDILTIVEQNVPESEGWWRCLLHGRQGLAPANRLQVLRETPADRPCPLLPRGPDTDLTSSGAPYQVQDLISPPPQGPVyEPMRSWVEGPSPATAQVYELPESPSSARIICEKTLSFPKQALSVLPRPTRASLPTLPSQVyDVPVQRQGFSTLERLEKQQFyDIPTSSQKALLHSSTSQG--RDVTLAPTMAFRQGGGYNPLSSPQKSERIHDTPVLLEKADVRNVSMTSFTKDSGSRAIPGSSAVHTG-----AVALsPQLGNT--VQRKNsLPEEPtyAFPTSR-DPLPSDAGGSYKVPSRFLIPRVEQQNTMPNIyDTPKAMQGVSHNAPKAMQGVSLAGKELERGREA-----PENSPWISGQTSFLSPDSDRLSVASSDSRASVVSSCSSISMDSSSGSSSEDSVKELWMDVDFAKETAVSLQHKVASSAAGLLLFVSRTWRFKDSLETNIHRIRRAADHVEESVREFLDFAQGVGGTACNLTDSYLQARIRDQLQTISSSYQTLLDAKGSLDRCNWSLEVLVTDKVQNSLDDLERFVATARIVPEDVKRFTSIVIANGKLLFKQNCEKGE-------MDLKCERCIRPPQRETESYQ-ESSPFDRQPTTEHSFELARKNRVNVCWQQSPNLQEKGKPTMEGKSNRNPDFHGMSPPPLTSPSPSGQNTERKIHLsKHsRLYFGALFKAISVFASSLSNGQPPEVFITQSKLVITVGQKLVDTLCSETQEKDERNEILCGSSHLCGLLKDLALATKSAVIQYPSPSALSLLQSEVERLEHHSRKFRDTLE
HEFL rat	MRGTGIREGATKTLLARALYDNHPDCSDELAFSRGDILTIVEQNVPESEGWWKCLLHGRQGLAPANRLQVLRETPVDRPCPLPPRGLDSDLTGSEAPCQVFNSFSPPTPGPVYEPMKSWVEGPSPATAQVYELPDSPSSARIICEKTLNFPKQALFVLPRPTRAsLPTLPSQVYDVPVQRQVSSTLERPEKQQFYDIPTSSQKAVFHISTSQG--PGVTLAPTTAFRQGGGYNPLSSPQKSDWIHDTPVSLGKADVRNASMTSFTKESCSNTIPGSSVVRIG-----AVTLSPQLGNA--VQKKSSPPEETSYAFLTPRGDSLPSDAGSSYKVPSRFLIPRVERQNTKPNIYDTPKAMQGVFQNTSKATQGVSLAGKELERGREA-----PENSPWVSRQTNFLSPDSDRLSVASSDSRASVVSSCSSLSTDSSPGSSSEDSVKELWMDLDFAKETAVALQSRVASSVAGLLLFVSRTWRFKDSLETNVNRIRGAADRVEESLREFLDFAQGVGGLACNLTDSYLQARVRDQLQTISSSYQTLLDAKGTLDRCNWSLEVLVVDKAQssVDDLERFVQVARVVPEDVKRFTSIVVANGKLLFKQNCERGE-------VDWRCERCIQPPQREAESHPERSSPFHKQPAAEHSLELAKKSRGDVCGQKSPNLQKKGKNTMEGKSNENQDFCGTSPTPLPSPSPSGQNVERKIRLSEHSRLYFGALFKAIGVFASSLSNSQPPEVFITQSKLAITIGQKLVDTLCSETQERDERNEILCGSSHLCGLLKDLALATKNAVIQYPSPSALGLLQSELEKLEYHSRKFRGTLE
	*:**:*:::*:*:*********::****************:**:********:****************:*:*:::*****:.:**::.::::*::::**..:.:**::*****:*:**:***:*:******:*::*:**********:*****:.:****:***************:*:::.::*:::****:****:*::**.:*.::**:  ..:.:.........:::..:..::::..:.::::...::.:::...::::..:.....:.::.....     ...:.:::.:.  .:.:.:.::...:.:...:....:.:...::::::.:::::::.:::.:::::.:::...:...........:.::::::.:.:.     ..::.:.:..:...::..::::..:::::::.:::::..:.:.:..::::.:::::..:.:.::::...::..:.::::::.:::::.:::.:.::::..::....:..:::.:::::::.::.:.:::::::.::.:.:::.::::.::..::..:..::..::.:::::.:.::.:.:::::::..::..:::.:::::::.:::.::::.:::..:       ....::..:.::::::::.. .:.:...:...:::.::..:.:...:.:...........................*.**.::::*:*:.***::**:*:***********::*::***::**:*.:******:*::*********:****:*:*****:******:****:*****:**::****:**::**:*:*:**.*:*:**:**:
Consensus	MRGTGIRDCAPKALLARALYDNCPDCSDELAFSRGDILTILEQNVPESEGWWKCLLHGRQGLAPANRLQILRETAADRPCPLFLRGLDEALASSEAPYQVPTLPRPPTPGPVYEQMRSWAEGPQPATAQVYELPDPPSSARIICEKTLSFPKQAILTLPRPTRASLPTLPSQVYDVPTQRRGPSTLERPEKQQLYDIPASPQKAGLHPPDSQA--RGVTLAPTTAFRQGGGYNPLSSPQKSEWIHDTPVSLGKADVRNASMTSFTKESRSRAIPGSSAVRIG-----AVALSPQLGNA--VQKKNSLPEEPSYAFLTPRGDPLPSDAGGSYKVPSRFLIPRVEQQNTKPNIYDTPKAMQGV--N--KA-QGVSLAGKELERGREA-----PENSPWISRQTNFLSPDSDRLSVASSDSRASVVSSCSSISTDSSSGSSSEDSVKELWMDLDFAKETAVALQHKVASSVAGLLLFVSRTWRFKDSLETNINRIRRAADHVEESVREFLDFAQGVGGTACNLTDSYLQARIRDQLQTISSSYQTLLDAKGSLDRCNWSLEVLVTDKVQNSLDDLERFVAVARIVPEDVKRFTSIVIANGKLLFKQNCEKGE-------ADLKCERCIQPPQRETESHQ-RSSPFDKQPAAEHSLELAKKNRANVCGQNSPNLQ-KGK-TMEGKSN-N-DF-G-SPGPLIPQPPSQQNPERKIRLSEHCRLYFGALFKAISAFAGSLSNSQPAEVIITQSKLVIMVGQKLVDTLCMETQERDERNEILRGSSHLCGLLKDLALATKNAVIQYPSPAALGHLQAEAEKLEQHSRQFRGTLE