Multiple Sequence Alignment:
GIT2 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670       680       690       700       710       720       730       740       750       760 )
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GIT2 human MSKRLRssEVCADCSGPDPSWASVNRGTFLCDECCsVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDkVHPNkAEFIRAKYQMLAFVHRLPCRDDDsVTAkDLSkQLHSSVRTGNLETCLRLLsLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGtQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSsLSGskDNVELILKtINNQHsVEsQDNDQPdyDsVAsDEDtDLEttAsKTNRQKsLDsDLsDGPVtVQEFMEVkNALVASEAkIQQLMkVNNNLSDELRIMQKkLQTLQSENSNLRkQAttNVyQVQtGsEytDtsNHSsLKRRPsARGsRPMsMyEtGsGQKPyLPMGEAsRPEESRMRLQPFPAHIGRSALVTSsssLPsFPsTLsWsRDESARRASRLEKQNstPEsDyDNTPNDMEPDGMGSSRKGRQRsMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDsYIPCsERIHVAVTEMAALFPKKPKsDMVRtsLRLLTSSAYRLQSECKKTLPGDPGsPTDVQLVTQQVIQCAYDIAKAAkQLVTITTKENNN
GIT2 iso10 human MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADRRLsLDLsELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQ--------------------------------------------------KLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMRLQPFPAHA------------------------------SRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN
GIT2 mouse MSKRLRsSDVCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRAD---SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGsPLSRSKDNVELILRTVSTQHStEsQDNDQPDyDsVAsDEDtDVETRASKANRQ--------------------------------------------------KLQTLQSENSSLRRQATASACQVQTGSDHKDTASHSsLKRRPsARGsRPMsMyETGSGQKPYLPMGEASHPEESRTRLQPFPTHIGRSALVtssssLPSFPSTLSWSRDESARRAsRLEKQNstPEsDyDNTACDPEPDDTGSTRKGRQRsMLWQGDGLLPDTAEPHSVPsPtLPSTEDVIRKtEQITKNIQELLRAAQENKHDsYIPCSERIHVAVTEMAALFPKKPKSDTVRTSLRLLTSSAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENSS
GIT2 iso3 mouse MSKRLRSSDVCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRADs--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSTQHSTESQDNDQPDYDSVASDEDTDVETRASKANRQ--------------------------------------------------KLQTLQSENSSLRRQATASACQVQTGSDHKDTASHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASHPEESRTRLQPFPTHA------------------------------SRLEKQNSTPESDYDNTACDPEPDDTGSTRKGRQRSMLWQGDGLLPDTAEPHSVPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDTVRTSLRLLTSSAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENSS
GIT2 iso4 mouse MSKRLRSSDVCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRADs--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSTQHSTESQDNDQPDYDSVASDEDTDVETRASKANRQKsLDsDLsDGPVTVQEFMEVKSALVASEAKRQQLMKVNNNLSDELRIMQKKLQTLQSENSSLRRQATASACQVQTGSDHKDTASHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASHPEESRTRLQPFPTHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTACDPEPDDTGSTRKGRQRSMLWQGDGLLPDTAEPHSVPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDTVRTSLRLLTSSAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENSS
GIT2 iso5 mouse MSKRLRSSDVCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRADRRLsLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSTQHSTESQDNDQPDYDSVASDEDTDVETRASKANRQ--------------------------------------------------KLQTLQSENSSLRRQATASACQVQTGSDHKDTASHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASHPEESRTRLQPFPTHA------------------------------SRLEKQNSTPESDYDNTACDPEPDDTGSTRKGRQRSMLWQGDGLLPDTAEPHSVPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDTVRTSLRLLTSSAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENSS
GIT2 rat MSKRLRSNDVCADCSGPDPSWASVNRGTLICDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYSNGANSIWEHSLLDPASVMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTHDSSGKTPVDYARQGGHRELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGsPLSRSKDNVELILRTVSNQHSTESQDNDQPDYDsVAsDEDtDVETRASRTNRQKsLDsDLsDGPVTVQEFMEVKHALVASEAKRQQLMKVNNNLSGELRIMQKKLQTLQSENSSLRRQATASACQVQTASDHKDTVSHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEANHPEESRTRLQPFPTHIGRSALVTSSSSLPSFPSTLSWSRDESTRRAsRLEKQNSTPESDYDNTAYDPEPDDTVSGRKGRQRsMLWQGDGPLPDTAEPHAVPSPALPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHAAVTEMAALFPKKPKSDTVRTSLRLLTASAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENSS
GIT2 chicken MSKRLRSSEVCADCSAQDPCWASINRGILICDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASVMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVAAKAGQTLQAELLAVYGADPGTQDSNGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKNGQHFVIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMYVyDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGNPLSGSKENVELILKSISNQHSSESQDNDQPDyDSVASDEDTDLETNAAKSTRQKSLDSDLSDGPVTAQEYMQVKNALVASEVKIQQLMKVNINLSDELRIMQKKLQTLQSENTNLRRQATTNIYQVQTGSEYTDPTNNSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEVTYPEESITRLQPFPPHIGRSAFVTSSSSLPSFPSTLSWSRDESTRRASKLEKQSSVPESDyDNTTASLELEETGSGRKGRQRSVIWQGEGSIPEDT--DTAPSSSLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSELVRTSLRLLTSSAYRLQSECKKTLPVETCPTTDIQLVTQQVIQCAYDIAKAAKQLVTITTKENNN
  *******::*****:::**:***:***:::************************:*************:****************:*************************************:*******************************************:******:****:***************:**:*************:******:**********************:****:***:**:  ****************************:*********************:*****************************************************::**:**:******:::::***:********************:**:*::::**..................... ............................*********::**:***::::****:*:::*::::********************************:::****::******:*:..............................*:****:*:********::::*:::::*.*******::*:*:*::*::::::::**::*****************************************:***************::*********:*********:*:**::::::**:*****************************::
Consensus MSKRLRSSDVCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKNGQHFLIPQRADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSNQHSTESQDNDQPDYDSVASDEDTDVETRASKANRQKSLDSDLSDGPVT-QE-M-VK-ALVASE-K-QQLMKVN-NLS-ELRIMQKKLQTLQSENSSLRRQATASACQVQTGSDHKDTASHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASHPEESRTRLQPFPTHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTACDPEPDDTGSTRKGRQRSMLWQGDGLLPDTAEPHSVPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDTVRTSLRLLTSSAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENSS
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.