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NRAGE human	MAQKMDCGAGLLGFQA--------------------------------------------------------EASVEDSALLMQTLMEAIQISEAPPTNQATAA-----ASPQSSQPPTANEMADIQVSAAAARPKsAFkVQNATtkGPNGVyDFsQAHNAk K101-ac K101-ub DVPNTQPk K109-ac K109-ub AAFkSQNATPkGPNAAyDFsQAATTGELAANkSEMAFk K147-m1 K147-ub AQNATTkVGPNAtyNFSQsLNANDLANSRPKtPFkAWNDTTkAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGkRTRkINNLNVEENSSGDQRRAPLAAGtWRSAPVPVTT-QNPPGAPPNVLWQTPLAWQNPSGWQNQtARQtPP-ARQsPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRAsQNPGAAQPRDVALLQERANKLVkyLMLkDYTkVPIkRSEMLRDIIREyTDVYPEIIERACFVLEkkFGIQLkEIDKEEHLYILISTPESLAGILGTTkDTPKLGLLLVILGVIFMNGNRAsEAVLWEALRkMGLRPGVRHPLLGDLrkLLTYEFVkQkYLDYRRVPNSNPPEyEFLWGLRsYHEtskMKVLRFIAEVQkRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE
NRAGE iso2 human	MAQKMDCGAGLLGFQNPDACRAVCHPLPQPPASTLPLSAFPTLCDPPYSQLRDPPAVLSCYCTPLGASPAPAEASVEDSALLMQTLMEAIQISEAPPTNQATAA-----ASPQSSQPPTANEMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPKGPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTPFKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPP-ARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE
NRAGE mouse	MAQKPDGGAGLRGFQ--------------------------------------------------------AEASVEDSALLVQTLMEAIQISEAPPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNATTKGPN---DYSQARNAKEMPKNQSKAAFKSQNGTPKGPHAASDFSQAAPTGKSA-KKSEMAFKGQNS-TKAGPGTTYNFPQsPsANEMTNNQPKT-AKAWNDTTkVPGADAQtQNVNQAKMA----DVGTSAGISEADGAAAQTSADGSQTQNVESRTIIRGKRTRkVNNLNVEENNSGDQRRAsLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVkYLMLkDYTkVPIKRSEMLRDIIREYTDVYPEIIERACFVLEkkFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRkLLTYEFVkQkYLDYRRVPNSNPPEYEFLWGLRSYHETSkMKVLRFIAEVQkRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE
NRAGE rat	MAQKPDGGAGLRGFQ--------------------------------------------------------AEASVEDSALLVQTLMEAIQISEAPPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNTTTKGPN---DYSQARNAKEMPKNQPKVAFkSQNATSKGPHAASDFSHAASTGKSAAKKSEMAFKGQNTTTKAGPSATYNFTQSPSANEMTNNQPKT-AKAWNDTTKIPGADAQTQNVNQAKMA----DVGTSAGISETDGAAAQTSADGSQAQNVESRTIIRGKRTRKINNLNVEENSNGDQRRAsLASGNWRSAPVPVTT-QNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPP-ARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQLPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSPNSRASQNQGPPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE
	****:*:****:***.                                                       :**********:***************:*****.....*************:**::*********::**:**:******...*:***:***::*::*:*:******:*:***:**:***:**.**::*::*******:**::**:**.:****.**::**:::*::***.:********:*:**:***********....*::*::****:***:*********:**:*************:********::******:**:*:********** **********:*********************** ***********:***********************************:*****:***::****:**:**:**:**:*:********::****::****::*:***:*************************:*:*******:*::*********************************************************************************************************:********:*****************************************************************************************************************:********************************************************:*:******:***:****************
Consensus	MAQKMDCGAGLRGFQ--------------------------------------------------------AEASVEDSALLMQTLMEAIQISEAPPTNQATAAASGPNASPQSSQPPTANEKADIQVSAAAARPKSAFKAQNATTKGPNGVYDFSQARNAKDMPNNQPKAAFKSQNATPKGPNAASDFSQAATTGELAANKSEMAFKAQNATTKAGPNATYNFSQSLNANDLANNRPKTPAKAWNDTTKAPGADAQTQNVNQAKMATSQADIETDAGISEPDGAAAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGNWRSAPVPVTT-QNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPP-ARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPLAWQNPPGWQSPPGWQAPPGWQGPQDWQGPPDWQLPPDWPLPPDWPLPSDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNQGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFAGPIIGPGGTASANFAANFGAIGFFWVE