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Cas-L human	MKYKNLMARALyDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQPASGLMQQTFGQQKLyQVPNPQAAPRDtIyQVPPsyQNQGIyQVPtGHGtQEQEVyQVPPSVQRSIGGTSGPHVGKKVITPVRtGHGyVyEyPSRyQKDVyDIPPsHttQGVyDIPPSSAKGPVFSVPVGEIKPQGVyDIPPtKGVyAIPPsACRDEAGLREKDyDFPPPMRQAGRPDLRPEGVyDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQsLsPNHPPPQLGQsVGsQNDAyDVPRGVQFLEPPAETsEKANPQERDGVyDVPLHNPPDAKGSRDLVDGINRLsFSSTGSTRSNMSTSSTSSKESSLSAsPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPGPGsLHLKNGPESIMNsTEYPHGGSQGQLLHPGDHKAQAHNKALPPGLSKEQAPDCsssDGsERSWMDDyDyVHLQGKEEFERQQKELLEkENIMKQNKMQLEHHQLSQFQLLEQEITKPVENDISKWKPSQsLPTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNkVMNSsNQLCEQLKTIVMATKMAALHYPStTALQEMVHQVTDLSRNAQLFKRSLLEMATF
Cas-L iso3 human	MWTRNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYDIPPSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKDYDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHPPPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRDLVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHNKALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
Cas-L mouse	MWARNLMARALyDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPVQETP-GHEQPTPGPMHQTFGQQKLyQVPNsQAASRDTIyQVPPSYQNQGIyQVPTGHGTPEQDVyQVPPSVQRNIGGTNGPLLSKKVITPVRTGHGyVyEYPSRYQKDVyDVPPsHsTQGVyDIPPSsVKGPVFSVPVGEIKPQGVYDIPPTQGVYAIPPSACRDEAGLREKEyDFPPPMKQDGKPDTRPEGVyDIPPTSTKTAGKDLHIKFPCDAPGGVEPMARRHQSFSLHHAPSQLGQSGDtQSDAyDVPRGVQFLEVPTETSEKANPEERDGVyDVPLHNPADAKGSRDVVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPSQDKRLRLDPDTAIEKLYRLQQtLEMGVCSLMSLVTTDWRCYGYMERHINEIRTAVDKVELFLREYLHFAKGALANASCLPELVLHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRADPANSHLKNGPNSIMNSSEYTHPGSQMQPLHPGDYKAQVHSKPLPPSLSKDQPPDCGSSDGSERSWMDDyDyVHLQGKEEFERQQKELLEKENIMKQSKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNNSVGAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVRNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
Cas-L rat	MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPVQEPS-SHEQPTPGPMHQNFGQQKLYQVPNSQAAPRDTIYQVPPSYQNQGIYQVPTGHGTPEQDVYQVPPSVQRNIGSTNGPHLGKKVITPVRVGHGYVyEHPSRYQKDVYDVPPSHTTQGVYDIPPSSVKGPVFSVPVGELKPQGVYDIPPTQGVYAIPPSACRDEAGLREKEYDFPPPMKQDGKLDTRPEGVyDIPPTSTKTVGKDLHTKFPCDAPGGAEPMARRHQSLSLHHAPSQVGPSGDTQSDAyDVPRGVQFLEVPTESSEKANLEERDGVyDVPLHNPADAKGSRDVVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPSQDKRLLLDPDTAIGKLYWLQQTLETGICSLMSLVTIDWRSYGYMERHINEIRTAVDKVELFLREYLHFARGALANASCLPEPVLLNKMNRELQRVDDSHQILSQTSHDLNECSWSLNVLAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRVDPGNSHLKNGPDSITNSIEYTHTGSQMQPLRPGDYKGQVHNKPLPPTLSKEQPPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQSKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNNSVGAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVRNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
	*:::**************************************************************:**::.:****::*:*:*:***********:***:*************************:**:**********:**:*:**:::********:*******:**********:****:***********:***********:***********:*******************:*******:*:*::*:***********:**::*****:*::**:**::**:******:*::*:*:*:*:*:::*:*************:*:*:*****::*************:*******:***********************************:*****.*******::*::***:**:*::***:***:***:**********************:*****::**:***:****::*:***:******:*********************:**********************************:*:**:***::*:::******.**:**.**:*.***:*:*:***:*:*:*:*:***.***:*:***:****************************************:*:**************************************::*:******************************************************************:********:*********************************************************
Consensus	MKYRNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQPAPGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTGHGTQEQDVYQVPPSVQRNIGGTNGPHLGKKVITPVRTGHGYVYEYPSRYQKDVYDIPPSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTQGVYAIPPSACRDEAGLREKDYDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKFNCDAPGAAEPMARRHQSLSLNHAPPQLGQSGDSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPADAKGSRDLVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVCSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLREYLHFAKGALANAACLPELILHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPDPGNLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHNKALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNNGVGAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVRNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF