Multiple Sequence Alignment:
p16-INK4A Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240    )
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p16-INK4A human MEPAAGssMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSyGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHrAGAR---------------------------------------LDVRDAWGRLPVDLAEELGHRDVARYLrAAAGGTrGsNHARI-----DAAEG---PsDIPD-----------------------------------------
p16-INK4A iso2 human -----------------------------------------------------------------------------------------------MLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGr------GAAGrArCLGPSArG---------------PG-------------------------------------------
p16-INK4A iso3 human MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVGRRSAAGAGDGGRLWRT--------KFAGELE----SG-------------S---------------------------------------ASILRKKGRLPGEFSEGVCNHR------PPPG-DALGAWETKEEE---------------------------------------------------------
p16-INK4A iso4 human -------------------------------------------MVRRFLVtLRIRRACGPPRVRVFV-----VHIPRLtGEWAAPGAPAAVALVLMLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGr------GAAGrArCLGPSArG---------------PG-------------------------------------------
p16-INK4A mouse --------MESAADRLARAAAQGRVHDVRALLEAGVSPNAPNSFGRTPIQVMMMGNVHVAALLLNYGADSNCEDPTTFSRPVHDAAREGFLDTLVVLHGSGAR---------------------------------------LDVRDAWGRLPLDLAQERGHQDIVRYLRSAGCSLCSAGWSLCTAGNVAQTDGHSFSSSTPRALELRGQsQEQs-----------------------------
p16-INK4A iso3 mouse -------------------------------------------MGRRFLVTVRIQRAGRPLQERVFL-----VkFVRSRRPRTASCALAFVNMLLRLERILRRGPHRNP-GPGDDDGQRsRSSSSAQLRCRFELRGPHYLLPPGARRsAGRLPGHAGGAARVR------GSAGCARCLGsPAAR---------------LGPR----AGTSRHRAIFAFRWVLFVFRWVVFVyRWERRPDRRA-
p16-INK4A rat -------------------------------------------MGRRFVVTVRIRRTGRSPQVRVFL-----VQFLGSsRPRSANGTRGFVALVLRPERIARRGPQPHP-GPGDDDGQRQSGSSPALLWCRFELRGPHHPLPTGARRSAGGLPRHSGSTAPGR------GAAGCARCLGSPAAR---------------PGPR----AGTSRRRAVFAVST----------LLRWERFPGHRQA
          ....................................:::.....:...:......:....    .......::.......::......:.:..::...... ................................:.::::.*:**.:::.::..:.     ::::.:.:::..::.               ....    ..... ..                             
Consensus -------------------------------------------MGRRFIQTMRIRRAGRAPQLRVFG-----VDF-RLSRPRHAAAAEGFVALLLRLERSQRRG-QP-P--PG-DDGQR-SG---A--R----LR-P-H--PTRARRAAGRLPGHAGGAAPGR------GAAGCARCLGPPARR---------------PGPR-----------------------------------------
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.