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SH2-B-beta human	MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLyLAsHPQyAGPGAEAAFsRRFAELFLQHFEAEVARAsGSLsPPILAPLsPGAEIsP-HDLsLEsCRVGGPLAVLGPsRssEDLAGPLPSSVSSSSTTSSKPKLKKRFsLRsVGRsVRGsVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVGrGLVSDGTsPGERWTHRFERLRLSrGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGrGGGVAGPPSGGGGQPQWQkCRLLLRSEGEGGGGSRLEFFVPPKASRPRLsIPCSSITDVRTTTALEMPDRENTFVVKVEGPsEYIMETVDAQHVKAWVSDIQECLsPGPCPATsPRPMTLPLAPGTSFLTRENTDSLELSCLNHSEsLPSQDLLLGPSESNDRLSQGAyGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLsLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSyVPSSQRQQEPTTSHDPPQPPEPPS-WTDPPQPGAEEASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQG-AGSGGDAGVPPMVQLQQSPLGGDGEEGGHPRAINNQySFV
SH2-B-beta iso2 human	MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISP-HDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDG-----CH---------PDASCTL----------MPFGASDCVTDHLP---------------------------------------------------------------
SH2-B-beta mouse	MNGAPSPEDGVFPSPPALPPPPPPSWQEFCESHARAAALDLARRFRLYLASHPQYAEPGAEAAFSGRFAELFLQHFEAEVARASGsLSPPVLAPLsPGVEIPPSHDLSLESCRVGGPLAVLGPSRssEDLAGPLPSSVPS-STTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGAVDSPSQAGPLETTSGPPVLGGNSNSNSSGGAGTVGRALANDGTsPGERWTHRFERLRLSrGGGTLKDGAGMIQREELLSFMGAEEAAPDPAGVGrGGGAAGLTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLsIPCSTITDVRTATALEMPDRENTFVVKVEGPSEYILETSDALHVKAWVSDIQECLSPGPCPAISPRPMTLPLAPGTSFFTKDNTDSLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASFSPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSTPYPPLDTPEAATGSFLFQGESEGGEGDQPLSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSQRQQ-ERSTSRDPAQPSEPPPW-TDPPHPGAEEASGAPEVAAATAAAAKERQEKEKAGSGGVQEELVPVAELVPMVELEEAIAPGTEAQGGAGSSGDLEVSLMVQLQQLPLGGNGEEGGHPRAINNQYSFV
SH2-B-beta rat	MNGAPSPEDGVFPSPPALPPPPPPSWQEFCESHARAAALDLARRFRLyLAsHPQYAEPGAEAAFsGRFAELFLQHFEAEVARASGSLSPPVLAPLSPGVEIPPSHDLSLESCRVGGPLAVLGPSRsSEDLAGPLPSSVSS-STTSSKPKLKKRFSLRSVGRsVRGsVRGILQWRGAVESPSQAGPLETTSGPPVLGGNSNSNSSGGAGTVGRALANDGTSPGERWTHRFERLRLSRGGGTLRDGAGVIQREELLSFMGAEEAAPDPAGVGRGGGAAGLTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSTITDVRTATALEMPDRENTFVVKVEGPSEYILETTDALHVKAWVSDIQECLSPGPCPAISPRPMTLPLAPGTSFLTKDNTESLELPCLNHSESLPSQDLLLGPSESNDRLSQGAyGGLSDRPSASFSPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSTPyPPLDTPEAATGSFLFQGEAEGGEGDQPLSGYPWFHGMLSRLKAAQLVLEGGTSSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSQRQQ-GREQAGSHAGVCEGDRCYPDAS--STFLPFGASD----------------------CVTEHFP---------------------------------------------------------------
	**********::**:*:*********:*************:***************:********:************************:*******:**:*.**********************************:*.**********************************:*::**:******:***********************:*::***********************:*:****::**************************:**::**********************************************:******:***********************:**.**:********************:***************:*::**:****:***************************************:*********************************:*******:*********:**********:*****************************:***:********************************************************************************:::*.::.::.:::::.*::....::..........::::.................:...:.:::.*...................... ........................................
Consensus	MNGAPSPEDGAFPSPPALPPPPPPSWREFCESHARAAALDLARRFRLYLASHPQYAEPGAEAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEIPPSHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGAVDPPSQAGPLETSSGPPVLGGNSNSNSSGGAGTVGRALANDGTSPGERWTHRFERLRLSRGGGALKDGAGMIQREELLSFMGAEEAAPDPAGVGRGGGAAGLPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTATALEMPDRENTFVVKVEGPSEYILETVDAQHVKAWVSDIQECLSPGPCPAISPRPMTLPLAPGTSFLTRDNTDSLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSAPYPPLDTPEAATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSQRRQQEREQAGDHAQPCEGDR--TDPPHPGAEEASGAPDVAAAAAAAAKERQEKEKAGAGGCVEEHVPV-ELVP-VELEEAIAPG-EAQG-AGS-GD--V--MVQLQQ-PLGG-GEEGGHPRAINNQYSFV