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BIKE human	MKKFSRMPKSEGGsGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCkREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCkTPIIHRDLkVENILLNDGGNYVLCDFGSATNKFLNPQkDGVNVVEEEIkkYTTLSYRAPEMINLYGGkPITTKADIWALGCLLyKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANsATTAtPSVLTIQSSAtPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSySANRSVADKEAIANFTNQkNIsNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSDKNVDsLSAPHNHPPEDPFGsVPFISHSGsPEKKAEHSSINQENGTANPIKNGKTsPASKDQRTGKKTs----VQGQVQKGNDEsEsDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPENLGHRPLLMDsEDEEEEEKHSSDSDYEQAKAKySDMssVyRDRsGsGPtQDLNtILLTSAQLsSDVAVETPKQEFDVFGAVPFFAVRAQQPQQE-KNEKNLPQHRFPAAGLEQEEFDVFTKAPFSKKVNVQECHAVGPEAHTIPGYPKsVDVFGStPFQPFLTSTsKsEsNEDLFGLVPFDEITGSQ--QQKVKQRsLQKLssRQRRTKQDMSkSNGKRHHGTPtSTKKTLKPtyRtPERARRHKKVGRRDsQssNEFLtIsDsKENIsVALTDGKDRGNVLQPEESLLDPFGAKPFHsPDLsWHPPHQGLsDIRADHNtVLPGRPRQNsLHGsFHsADVLKMDDFGAVPFTELVVQSITPHQSQQSQPVELDPFGAAPFPSKQ
BIKE iso2 human	MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSsKGHLkAYFASQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
BIKE mouse	MKKFSRMPKSEGsGGGAAAGGAAGG---GLGGGFASSSMGVRVFAVGRYQVTLEESLAEGGFSTVFLVRTHSGIRCALKRMYVNNTPDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGSFTIPDNSRYSHNVHCLIRFMLEPDPECRPDIFQVSYFAFKFAKKDCPVSNINNSFLPSTLPEPMTATEAAARKSQMKARITDTIGPTETSIAPRQRPKANST-AATSSVLTIQSSATPVKVPAPGEFSNHKPKGALRPGNGSEVLMVQGPPQQPPQQHRVLQQLQQGDWRLQQLHLH-RHPHHHHQQQQQQQQQQQQQQLQQQ--------QQQQQQLLQNAYLQQYQHAMHQQHILQQQFLMHSVYQPQPPASQYPAMMQQYQQAFLQQQMLARHQQPAQQVSPEYLTSPQEFSPALVSYASSLPAQVGTIVDSSYGANRSVAEKEAVANFTNQKTISHPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLGAStPSDKTVDLPPAPHSRPPEEPFASVPFISHSGsPEKKTTEHsPNQKSITANLTKNGGSsPLCKDQRAGKKTsENPVIRGQVQKGHDDsEsDFESDPPSPKSSEEEQED--EDAQGEHGDFNDDDTEPENLGHRPLLMDSEDEEEDDKHSSDSECEQAKTKRGDTSSLRRDKPGVAPDTALLT----PAR--SPADALTPSQEFDVFGAVPFFAAPAPQSLQHRGDGKNLsQHAFP----EQEDFDVFTKAPFNKKVsVQDWPAVGPDARPLPARPRsVDIFGSTPFQPFSVSASKsEsKEDVFGLVPFEEITGSQQ-QQKVKQRSLQKLsSRQRRTKQDVSKSNGKRHHGtPTSAKKTLKPPYRtPERARRHKKVGRRDsQssNEFLtISDsKENISVALTDGKDRAsVLPSDESLLDPFGAKPFHPPDL-WHQPHQGLSDICVDHTTILPGRPRQNsVHGsFHSAETLRMDDFGAVPFTELVVQSVTPQ---QSQPVELDPFGAAPFPSKQ
BIKE rat	-------------------------------------------------------MTGVGGFSTVFLVRTHSGIRCALKRMYVNNTPDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFALPFGESQVAICDGSFTIPDNSRYSHNVHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSILPSTLPEPMTATEAAARKSQMKARRLSV--------------------------------------------GRAPSCGALRPGNGSDILMVQGPTQQPPQQHRVLQQLQQGDWRLQQLHLH-RHPQQQQQQQQQQ------QQQQQQ--------QQQQQQLLQNAYLQQYQHAMHQQQILQQQFLMHSVYQPQPLASQYPTMMQQYQQALLQQQMLAHHQQPAQQVSPEYLTSPQEFSPALAPYGSSLPAQVGTIVDSSYGATRSVAEKEAVANFTNQKTISHPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLGESTPSDKNVDPPPAPHSRPPEEPFASVPFISHSGSPEKK-TEHSPNQKNITAHPTKNGSSSPICK---AGQKTSENPVVRGHAQKGNDESESEFESDPPSPKSSEEEQED--EDAQGEHGDFNDEDTEPENLGHRPLLMDSEDEEEDDKHSSDSECEQAKAKGGESSSLRRNKPGGAPEPA-------------SSPALTPSQEFDVFGAVPFFAVPAPE-LQHRGSGKSVSQQMFP----EQEEYDVFTKAPFSKKVTVQDWPAVRPDTRPLPARPRsVDIFGSTPFQPFSTAASKSESKEDVFGLVPFEEITGSQQQQQKVKQRSLQKLSSRQRRTKQDVSKSNGKRHHGTPTSAKkPLKPPYRTPERARRHKRVGRRDsQSSNEFLTISDSKENISVALtDGKDRASVLPPDESLLDPFGAKPFHPPDL-WHQTHQGLSDICVDHTAILPGRPRQNSVHGSFHSADALRMDDFGAVPFTELVVQSVSPQ---QSQPVELDPFGAAPFPSKQ
	::::::::::::..:::::::::::...:.:.:.:.::.:::::::::.::::::::::************:*************:****:*************************************************************:*************************************:***********************************************************************:*************:**********:*:*************:***************************.:**:*******:********:***::::::::::::::::::::::..:::.::::::::::::::.::::::::.::********:::*::***:*************************:.***::::******::::::**:***........::::::***:**:******::**::***************.*****:**:*****::******.**:::**:***************::*:**********:****:*:****:***:*******:**:*********************************:::.:.:.:::.::...:::..:::.::.::::::::::::::....:.::...::...:::..::..:....:.:::......:.::::.:.:::.::::::::::::::..:  :..:::.:::::.:::::::::::::::::::::..::::::..::::.:....::..:...:..:......    ...  ......::.::::::::::::::.:....:.....:...:..::    :::..::::::::.:::.::...::.:.....:..:.:::.:::::::::..:.:::::.::.::::::.::::::. ::::::::::::::::::::::.::::::::::::::.::.:::.:::::::::::.::::::::::::::::::::::::::::::::..::...:::::::::::::.::: ::..:::::::.:::.:.:::::::::.:::::::..:.::::::::::::::::..:.   :::::::::::::::::::
Consensus	MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHQQQQQQLLQNAYLQQYQHAMQQQQILQQQFLMHSVYQPQPSASQYPTMMQQYQQAFLQQQMLAQHQQPAQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYGANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLGESAPSDKNVDLPPAPHSRPPEEPFASVPFISHSGSPEKK-TEHSPNQKNITANPTKNGGSSPACKDQRAGKKTSENPVVRGQVQKGNDESESDFESDPPSPKSSEEEQED--EDAQGEHGDFNDDDTEPENLGHRPLLMDSEDEEEDDKHSSDSECEQAKAKRGDMSSLRRDKPGGAPDQAL-T-----A---SDAAALTPSQEFDVFGAVPFFAVPAPQ-LQHRGNGKNLSQHAFP----EQEEFDVFTKAPFSKKVNVQDWPAVGPDARPLPARPRSVDIFGSTPFQPFSTSASKSESKEDVFGLVPFEEITGSQQ-QQKVKQRSLQKLSSRQRRTKQDVSKSNGKRHHGTPTSAKKTLKPPYRTPERARRHKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRASVLPPDESLLDPFGAKPFHPPDL-WHQPHQGLSDICVDHTTILPGRPRQNSVHGSFHSADALRMDDFGAVPFTELVVQSVTPQ---QSQPVELDPFGAAPFPSKQ