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NEK4 human	MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNAssRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVyRIIEGKLPPMPRDYSPELAELIRTMLsKRPEERPSVRSILRQPYIKRQIsFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTyIMGEGKCLSQEKPRASGLLKsPAsLKAHTCKQDLSNTTE-LATISSVNIDILPAKGRDsVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALsPKLECSGTILAHsNLRLLGssDsPAsAsRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNsGSEPSLsRQRRQKRREQTEHRGEKRQVRRDLFAFQEsPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSsKDRPLSARERRRLKQSQEEMsssGPsVRKAsLSVAGPGKPQEEDQPLPARRLssDCSVTQE---------RKQIHCLsEDELSSSTSSTDKsDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGsEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMNF
NEK4 iso2 human	MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTE-LATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQ----------------------------------------------DQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQE---------RKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVSVSLTVSRCLC-YRI-------F------
NEK4 mouse	MPQAAYCYMRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLtRTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTMLSRRPEERPSVRSILRQPYIKHHISLFLEATKAKTSKNNVKNCDSRAKPVAAVVSRKEESNTDVIHYQPRSSEGSALHVMGEDKCLSQEKPVDIGPLRSPAsLEGHTGKQDMNNtGESCATISRINIDILPAERRDSANAGVVQESQPQHVDAADEVDSQCSISQEK-ERLQGNTKSSDQPGNLLPRRssDGGDGEGSELVKPLYPSNKDQKPD-----------------------------------------------QDQVT--GIIENQDSIHPRSQPHSSMSEPSLSRQRRQKKREQtAHSGTKS-------QFQELPPRLLPSYPGIGKVDIIATQQNDGNQGGPVAGCVNSSRTSSTASAKDRPLSARERRRLKQSQEEMLPSGPAVQRTPs-AVEPLKPQEEDQPIPAQRFSSDCSITQMNHTLPREKEKRLMHGLsEDELSsSTSSTDKSDGDSREGKSHTNEMKDLVQLMTQTLRLEAKEsCEDLQVLNPGSEFRLHRKYRDTLVLHGKVAEEVE-PHCTELPTGIIPGSEKIRRIVEVLRADVIQGLGIQLLEQVFDLLGEEDELEREARLQEHMGDKYTTYCVKARQLKFFEENVSF
NEK4 rat	MPQAAYCYLRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHSDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSAELAELIRTMLSRRPEERPSVRSILRQPYIKHHISLFLEATKAKTSKNNVKNCDSRAKPVAAVVSRKEEPNHEMIPYQPRSSEGSAVHATGEDKCLSQEKPVDIGPLKSPASLEGHTGKQDMNRTAESCATVSRINIDILPAERRDSAKDGTVEEGRPQHVDASNEVDRQCSISQEK-ERLQGNSKSSDQPENLLPRWssGGGDGEGNELVKLLysSGKDQKPQ-----------------------------------------------QDQVTSGCILEDQDSIHPRLQPHSSVSEPSLSRQRRQRKREQTNHGRAKS-------QLQEsPPRLVPSHPDTGKADIISTQQSDGNQSGPVARSVNGSRSSSTASSKDRPLSARERRRLKQSQEEMLPSGPAVQRTPS-SVEPVKPQEEDQPIPAQRFSSDCNITQVNPTLLREK-KRLIHGLsEDELSSSTSSTDKSDGDSREGKSHTNEMRDLVQLMTQTLRLEAKESCEDLHVPNPGSEFRLHRKYRDTLVLHGKAAEEGE-PPCVELPPGITPGSEKIRRIVEVLRADVIQGLGVQLLEQVYDLLEEEDELEREARLQEHMGDKYTTYSVKARQLKFFEENVSF
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Consensus	MPQAAYCYLRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSRRPEERPSVRSILRQPYIKRQISLFLEATKAKTSKNNIKNCDSRAKPFAAVVSREAESNHEVIHPQPRSSEGSATHIMGEDKCLSQEKPRAIGLLKSPASLEAHTCKQDLNNTTESCATISRINIDILPAERRDSASDGFVQENQPRHLDASNELDGQCSISQEEEERLQDNTKSSAQPENLIPRWSSDGGDGEGNELVKPLQPLIKDQKPKDQ---------------------------------------------QDQVAGECIIEKQDRIHPRLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRLLPSHPIVGKVDIISTQQEAENQRRPVAGSVNSSRSSEMASSKDRPLSARERRRLKQSQEEMLPSGPAVRRAPLSVAEPGKPQEEDQPIPARRLSSDCSITQEN-TL-REK-RRQIHCLSEDELSSSTSSTDKSDGDSREGKGQTNEINALVQLMTQTLRLDAKESCEDLPVANPGSEFRLHRKYRDTLILHGKVAEEAEEIHCKELPSAIMPGSEKIRRIVEVLRADVIRGLGVQLLEQVYDLLEEEDELDREARLQEHMGDKYTTYSVKARQLKFFEENVSF