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PLK4 human	MATCIGEKIEDFKVGNLLGKGsFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYtLCGtPNyISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLsLssVLDHPFMsRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGsLFDKRRLLIGQPLPNKMtVFPKNKsSTDFSSSGDGNSFYtQWGNQET--SNSGRGRVIQDAEERPHSRYLRRAysSDRSGTSNSQSQAKTyTMERCHsAEMLsVSKRSGGGENEERysPTDNNANIFNFFKEKTSsSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEyDSIsPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQNTMKYMtALHsKPEIIQQECVFGSDPLSEQSKTRGMEPPWGyQNRTLRsItsPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPsPTDNIsRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKsYtLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALsPPPsVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH
PLK4 mouse	MAACIGERIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMSRNPSPKSKDVGTVEDsMDsGHAtLsttItAssGtsLsGsLLD-RRLLVGQPLPNKITVFQKNKNSSDFS-SGDGSNFCTQWGNPEQEANSRGRGRVIEDAEERPHSRYLRRAHSSDRASPS-NQSRAKTYSVERCHSVEMLSKPRRS-----------------------------------LDENQHSSNHHCLGKTPFPFADQTPQMEMVQQWFGNLQMNAHLGETNEHHTVSPNRDFQDYPDLQ-DTLRNAWTDTRASKNADTSANVHAVKQLSAMKYMSAHHHKPEVMPQEP--GLHPHSEQSKNRsMESTLGYQKPTLRSITSPLIAHRLKPIRQKTKKAVVSILDSEEVCVELLRECASEGYVKEVLQISSDGTMITVYYPNDGRGFPLADRPPLPTDNISRYSFDNLPEKYWRKYQYASRFIQLVRSKTPKITYFTRYAKCILMENSPGADFEVWFYDGAKIHKTENLIHIIEKTGISYNLKNENEVTSLKEEVKVYMDHANEGHRICLSLESVISEEEKRSRGSSFFPIIVGRKPGNTSSPKALSAPPVD-PSCCKGEQAsASRLSVNSAAFPTQSPGLSPSTVTVEGLGHTATATGTGVS-----SSLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPNFQ
PLK4 rat
	**:****:***************************************************************:*********:**********************:*****:******************************:*******************:*******************************:*************************************:***:**:*****************************:*:****:******:******:**:*****:**:****:*.****:*******:***:***:*:***.****::*:*****:*:..:::******:**************:****:::*.:**:****::*****:****:::**...................................:*:**::***:*:*********:***:*:*********:****::*:*::::*******::****.**::******:::**:*:*:*:*:***:::****:*:*:***:::**:..*::*:*****:*:**:::***::*********:****************************::*:**::************::**:****:***********:***************************:******:******************************:******::*::*****:**:**:*:**:*****:*:*************:***:*****:::*:::*****:*****:********:**::.::::::*:**::*::::***:***:*:*:**:**:****:*:**:**::*.....::***************************************************:*************:***********************:
Consensus	MAACIGERIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMSRNPSPKSKDLGTVEDSIDSGHATISTAITASSGTSISGSLLDKRRLLIGQPLPNKITVFQKNKNSSDFSSSGDGNNFCTQWGNQEQEANNRGRGRVIQDAEERPHSRYLRRAHSSDRAGPSNNQSRAKTYSMERCHSAEMLSKPRRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERLDNNQALSNHHCLGKTPFPFADQTPQMEMVQQWFGNLQINAHLRETNEHDSISPNRDFQDHPDLQKDTLRNAWTDTRAKKNADASANAHAVKQQNAMKYMSAHHHKPEIIQQECVFGLDPHSEQSKNRGMEPPLGYQNRTLRSITSPLIAHRLKPIRQKTKKAVVSILDSEEVCVELLRECASQEYVKEVLQISSDGNMITIYYPNDGRGFPLADRPPLPTDNISRYSFDNLPEKYWRKYQYASRFIQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGAKIHKTENLIQIIEKTGISYNLKNENEVNSLKEEIKMYMDHANEGHRICLALESIISEEERRSRGAPFFPIIIGRKPGNTSSPKALSAPPSDDPNCCKRERASANRLSMNSAAFPTQAPGLNPSMVTNEGLGHTATASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFQ