(        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670  )
	|         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |
RIPK1 human	MQPDMsLNVIKMkssDFLEsAELDsGGFGKVsLCFHRtQGLMIMKTVYkGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLkAEMSTPLSVkGRIILEIIEGMCYLHGKGVIHkDLkPENILVDNDFHIkIADLGLAsFkMWskLNNEEHNELREVDGTA-KkNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEkFRPFYLSQLEEsVEEDVksLKkEYsNENAVVkRMQsLQLdCVAVPssRsNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSkLQDEANyHLyGsRMDRQTKQQPRQNVAYNREEERRRRVsHDPFAQQRPyENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLyQNNGLyssHGFGTrPLDPGtAGPrVWyRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIkYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAkYQAIFDNTTSLTDkHLDPIRENLGkHWKNCARkLGFTQsQIDEIDHDYERDGLKEkVYQMLQKWVMREGIk K642-ac K642-ub GATVGkLAQALHQCSRIDLLSsLIYVSQN
RIPK1 iso2 human	MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAE----------------------------------------------IADLGLASFKMWSKLNNEEHNELREVDGTA-KKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
RIPK1 mouse	MQPDMSLDNIKMAssDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLkGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWsKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICtEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKkEyPDQsPVLQRMFsLQHDCVPLPPsRsN--SEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVsHDPFAQQRARENIkSAGARGHsDPSTTSRGIAVQQLSWPATQ---TVWNNGLYNQHGFGT-------TGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNSQPP----NNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEkVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS
RIPK1 rat	MQPDMSLDNIKMASDDLLERKDLDSGGFGKVSLCFHRTHGFVILKKVYTGPNRAEYNEALLEEGKMMHRLRHDRVVKLLGIIIEEGNYSLVMEYMEQGNLMHVLKTKESVPLSVKGRIIVEIIEGMHYLHDEGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEEHNKQREASSVT-KKNGGTLYYMAPEHLTDINTKPTEKSDVYSFAIVLWAIFANKEPYENVICTEQFLVCINSGNRPNVEDILEFCPREIISLMERCWQTNPEDRPTFFGIEKEFKPFYLSQFEEYVEEDVASLKKEYPSQsPVLKRMFSLQHDCVPLPPSRSN--SEQPGSLHSSQGLPMGPVEESWFSSSPEYPQEENERSVQAKLQEEASYHAFGIFAEKQTKSQPRLNEAYNREEERKRRVsHDPFAQQRVHENVKSAGAKGLPYPSTTSHGNAAHQLSGPASQIKVPLWNNGVYNHHGFGA-------TGTGVWYGPSVSQSYNAYKTPVPETNLPGsIPTMPYISLAPPDDSIRCTIYNSSRVQIGNYNYMDLGPSSQPP----TNTCKVESTSRHQAVFANTTSLTDKHLNPIRENMGKQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRTDLLNQLIQASQS
	*******::***:*:*:**.::************:**::*::*:*:**:***::*:**:****:***:****:*******:*****:*********:********:....:::.:::::.::::::.:::..:::::::::::::::.:::::*****:****:****::*::*:::*::::: *:*************:*:*:***********::*******:******:**::*::.**:*****:*::*:*:*********::**:::**:****.***::*:*****::**:*****:******:.:::*::**:***:***::*:****..:************.*********::*:*:**:**::*:*:***:**:**::*:::::***.***:*:********:************:.**.::::::*.:::*::*:*:*::*:*::::*..:..:***:*:.****:.......:*::***.*..*::::::::******.:*::****:.*::::*::*::**:**:::***::***::*..*:::....::::*:*:::::**:*:*******:**:*****:*::***********:**************************:****:***************:*:***:.**.:**:
Consensus	MQPDMSLNNIKMASSDLLESADLDSGGFGKVSLCFHRTQGLMILKKVYKGPNRAEHNEALLEEAKMMNRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKAEESVPLSVKGRIIVEIIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGLASFKMWSKLNNEEHNEQREVDGTA-KKNGGTLYYMAPEHLNDINAKPTEKSDVYSFAIVLWAIFANKEPYENAICEQQLIMCIKSGNRPNVDDILEYCPREIISLMERCWQANPEARPTFPGIEEEFRPFYLSQLEESVEEDVASLKKEYPNQNAVLKRMQSLQHDCVALPPSRSNSASEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENERSLQAKLQDEANYHAFGIRADRQTKQQPRQNEAYNREEERRRRVSHDPFAQQRPYENFQNAEAKGTAYPSAASHGNAVHQLSGLASQPQVLYQNNGLYNSHGFGTRPLDPGTAGPRVWYRPIPSQMPSLHNIPVPETNYLGNTPTMPFSSLPPTDDSIKYTIYNSSGIQIGAYNYMDIGGTSQPLLDSTNNNCKEEPAARHQAIFDNTTSLTDKHLNPIRENLGKQWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWLMREGIKGATVGKLAQALHQCCRIDLLNSLIYASQN