Multiple Sequence Alignment:
PKACB Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390         )
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PKACB human ------------------------------------------------MGNAAtAKKGsEVEsVkEFLAKAkEDFLKkWENPTQNNAGLEDFERkktLGtGsFGRVMLVKHkATEQyyAMKILDKQKVVKLkQIEHtLNEkRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEyLHSLDLIyRDLKPENLLIDHQGyIQVtDFGFAKRVKGRtWtLCGtPEyLAPEIILSkGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGkVRFPsHFSsDLkDLLRNLLQVDLTkRFGNLkNGVSDIkTHKWFATTDWIAIYQRkVEAPFIPkFRGsGDtsNFDDyEEEDIRVsItEkCAKEFGEF
PKACB iso2 human MMAAYREPPCNQyTGTTTALQKLEGFASRLFHRHsKGTAHDQKTALENDSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
PKACB mouse ------------------------------------------------MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKktLGtGsFGRVMLVKHKATEQyyAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILSkGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTkRFGNLkNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPkFRGsGDTSNFDDYEEEEIRVsITEKCGKEFCEF
PKACB iso4 mouse -MAAHKELssGQHSGTPTALQKLEGFAsRLFHRHsRGTAQEHRAALEDDGLRASEHTASWDKSMKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF
PKACB rat ------------------------------------------------MGNTAIAKKGSEVESVKEFLAKAkEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVkHKATEQyyAMKILDKQKVVKLKQIEHTLNEkRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRtWtLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSsDLkDLLRNLLQVDLTkRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGsGDTSNFDDYEEEEIRVsITEKCGKEFCEF
PKACB cow ------------------------------------------------MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPAPNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWtLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVsITEKCGKEFCEF
PKACB iso2 cow -MAAYREVPCNQYTGT-TALQKLEGFASRLFHRHSKGTAHDQKTALENDSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPAPNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWtLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVsITEKCGKEFCEF
   ...... ........ ...............................:::::.::::::::*:************:*****:::**************************************************************:*********:********************************************************************************************************************************************************************************************************************************:*********:***:**
Consensus ------------------------------------------------MGNAASAKKGSEVESVKEFLAKAKEDFLKKWENPPPNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCGKEFCEF
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.