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PKN3 human	MEEGAPRQPGPSQWPPEDEkEVIRRAIQkELKIKEGVENLRRVAtDRRHLGHVQQLLrSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGtPKERkLLAAAQQMLRDSQLkVALLRMKISSLEASGsPEPGPELLAEELQHRLHVEAAVAEGAkNVVkLLSSRRTQDRkALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVkPTALTGTLQVRLLGCEQLLTAVPGRsPAAALASsPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCsSPSTIsPPKGCPRtPTTLREAsDPAtPsNFLPkKTPLGEEMtPPPkPPRLYLPQEPtsEEtPRTKRPHMEPRTRRGPsPPAsPtRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGk K583-ac K583-ub YYAIkALKkQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLkLDNLLLDAQGFLKIADFGLCKEGIGFGDRtstFCGtPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQkCPEKRLGAGEQDAEEIkVQPFFRtTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALtPPAPHSLLTARQQAAFRDFDFVSERFLEP
PKN3 mouse	MEH---RKPGTGQRAPKDEKEMVRRAIQKELKIKEGMENMRRVATDRRHLGHVQQLLRASNRRLEQLHGELRELHAQVLLPASA----EPVTSEPQPRAEQSRARLSEALHRQLQVELKVKQGAENMIHTCASGTPKERKLLAAAQQMLKDSQLKVALLRMKISSLESSGSPEPGPDLLAEELQHRLRVEAAVAAGAKNVVKLLGGQRMQDRKALAEAQAQLQESSQKLDLLRLALELLLERLPPTHSLRSRVTQELWMAMLGNPQPLGTLVKPIALTGTLQVRLLGCKDLLVAVPGRSPMAVLAGSPSESWLRTRSRQQRGGGELASEVLAVLKVDNRVVGQTGWGLVAEKSWDQSFIISLDRARELEIGVHWRDWRQLCGVAFLKLEDFLDNACHQLSLSLVPQGRLFAQVTFCEPVIERRPRLQRQRCIFSKRRGRDFMRASQMNLSMAAWGRLVMSLLPPCSSPNTASPPKGRPSTAVC--GTPSAASPSNFLPMkTLSKEDTKPPPKPPRLYL-QEP-APGTPCTKRPHMDPRPAVVPALAALSTRKPPRLQDFRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILEtVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHEDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTStFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQALLARTVQPPFVPTLCGPADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVSEQFLES
PKN3 rat	MEH---RKPRTGQRAPEDEKEMIRRAIQKELKIKEGMENMRRVATDRRHLGHVQQLLRASNRRLEQLHGELRELHAQVLLPAPA---HEPMTSGPQPRAEQSRARLLEALHRQLEVELKVKQGAENMIHTCASGTPKERKLLAAAQQMLKDSQLKVALLRMKISGLEASGSPEPGPDLLAEELQHRLRIEAAVAAGAKNVVKLLGGQRIQDRKALAEAQAQLQESSQKLDLLRLALELLLERLPPTHSLRSRVTRELRMAMLGNPQPLGTLVKPIALTGTLQVRLLGCKELLATVPGRSPMAVLAASPSEGWLRTRSRQQRGGGELASEVLAVLKVDNRVVGQTGWGLVAEKSWDQAFSISLDRARELEIGVHWRDWRQLCGVAFLKLEEFLDNACHQLSLSLVPQGRLFAQVTFCEPVIERRPRLQRQRRVFSKRRGQDFLRASQMNLSMTAWGRLVMSLLPPCSSPSTVSPPKGCPSAAAC--ETSSSASPSNFRPVKTLPGEDMKPPPKPPRLYL-QEP-APGTPCTKRPHMDPRTGVAPPLAALSTRNPPQLQDFRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACIQTSSHACFVTEFLPGGDLMMQIHEDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEDEVFECIVNADVPCPHFLSAQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQALLARTVQPPFVPTLCGPADLRYFEGEFTSLPPTLTPPVPRRSLSARQQAAFRDFDFVSKRFLES
	**:...*:*:::*::*:****::*************:**:******************:*****************::***:::....**::*:*:*:***:***::***:***.************:*********************:**************:**:********:**********::*****:*********:::*.****************************:***:***:*:******:**::*::*:***:**:***:*************:.**::******:*:**:****:****::::***:************************:***:****:*.*:*:***********************:**:*****************:********:************:::******:**:*******:*:*******:********:*:*****:*:::::..:::::*:****:*.**:.:*:::**********.***.:::**:******:**::::*:::*::**:**:**********************:******************:****:**********:**:************.************:******:************:**:*************:*************************************************************************************:***:***::*:*:*:***:****:*******:*********:***********************:**********************:***:****::.::*:**************::***:
Consensus	MEH---RKPGTGQRAPEDEKEMIRRAIQKELKIKEGMENMRRVATDRRHLGHVQQLLRASNRRLEQLHGELRELHAQVLLPAPA---AEPVTSGPQPRAEQSRARLLEALHRQLQVELKVKQGAENMIHTCASGTPKERKLLAAAQQMLKDSQLKVALLRMKISSLEASGSPEPGPDLLAEELQHRLRVEAAVAAGAKNVVKLLGGQRIQDRKALAEAQAQLQESSQKLDLLRLALELLLERLPPTHSLRSRVTRELRMAMLGNPQPLGTLVKPIALTGTLQVRLLGCKDLLAAVPGRSPMAVLAASPSEGWLRTRSRQQRGGGELASEVLAVLKVDNRVVGQTGWGLVAEKSWDQAFIISLDRARELEIGVHWRDWRQLCGVAFLKLEDFLDNACHQLSLSLVPQGRLFAQVTFCEPVIERRPRLQRQRRIFSKRRGQDFLRASQMNLSMAAWGRLVMSLLPPCSSPSTASPPKGCPSTAAC--ETSSAASPSNFLPKKTLLGEDMKPPPKPPRLYL-QEP-APGTPCTKRPHMDPRTAVAPALAALSTRKPPRLQDFRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACIQTSSHACFVTEFLPGGDLMMQIHEDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFECIVNADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQALLARTVQPPFVPTLCGPADLRYFEGEFTSLPPTLTPPVPRSSLTARQQAAFRDFDFVSERFLES