(        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540   )
	|         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |
Src human	MGSNKSKPKDAsQRRRsLEPAENVHGAGGGAFPAsQtPsKPAsAdGHRGPsAAFAP-AAAEPkLFGGFNssDtVtsPQRAGPLAGGVTTFVALyDyEsRTETDLsFKKGERLQIVNNt------EGDWWLAHSLstGQtGyIPSNyVAPSDSIQAEEWyFGKITRRESERLLLNAENPRGtFLVRESEttKGAyCLSVSDFDNAKGLNVkHYKIRKLDSGGFyITSRTQFNSLQQLVAyySKHADGLCHRLTtVCPtSKPQtQGLAKDAWEIPREsLRLEVKLGQGCFGEVWMGtWNGTTRVAIkTLKPGtMsPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIyIVTEyMSKGsLLDFLKGETGKYLRLPQLVDMAAQIASGMAyVERMNyVHRDLRAANILVGENLVCKVADFGLARLIEDNEytARQGAk K426-ac K426-ub FPIk K430-ac K430-ub WTAPEAALyGRFTIKSDVWSFGILLTELTTKGRVPyPGMVNREVLDQVERGyRMPCPPECPEsLHDLMCQCWRKEPEERPTFEYLQAFLEDyFTstEPQyQPGENL
Src iso2 human	MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAP-AAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Src mouse	MGSNKSKPKDAsQRRRsLEPSENVHGAG-GAFPASQTPSKPASADGHRGPSAAFVPPA-AEPKLFGGFNSSDTVTsPQRAGPLAGGVTTFVALyDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLsTGQTgYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARlIEDNEYTARQGAKFPIKWTaPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFtSTEPQYQPGENL
Src iso1 mouse
Src rat	MGSNKSKPKDASQRRRsLEPAENVHGAG-GAFPASQTPSKPASADGHRGPNAAFVPPAAAEPKLFGGFNSSDTVTsPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNT------EGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAyCLSVSDFDNAKGLNVKHYKIRKLDSGGFyITSRTQFNSLQQLVAyYSKHADGLCHRLTTVCPTSkPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEyTARQGAkFPIKWTAPEAALyGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQyQPGENL
Src chicken	MGSSKSKPKDPsQRRRsLEPPDSTH---HGGFPASQtPNKTAAPDTHRtPsRSFGT-VATEPKLFGGFNTSDTVTsPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNT------EGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEyTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDyFTSTEPQyQPGENL
	***:******:*********::::*:::.*:*******:*:*::*:**:*:::*::.:::*********:***********:************************************......**********:***************************************:*******************************************************:*********************:**************************************************************************************************:***********:************:**************************************************************************************************************************************:*******************************
Consensus	MGSNKSKPKDASQRRRSLEPAENVHGAG-GAFPASQTPSKPASADGHRGPSAAFVPPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNT------EGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL