Multiple Sequence Alignment:
MKK4 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410)
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MKK4 human MAAPsPsGGGGSGGGSGsGTPGPVGsPAPGHPAVSSMQG-----------KRkALkLNFANPPFkStArFTLNPNPTGVQNPHIERLRtHsIESSGkLkIsPEQHWDFTAEDLkDLGEIGRGAYGSVNKMVHKPSGQIMAVkRIRSTVDEkEQkQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVkALNHLKENLKIIHRDIkPSNILLDRSGNIKLCDFGISGQLVDsIAKtRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPAtPssPMYVD
MKK4 iso2 human MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGFQINFCEKAQSKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
MKK4 mouse MAAPSPSGGGGSGGG--GGTPGPIGPPASGHPAVSSMQG-----------KRKALKLNFANPPVkStArFTLNPNTTGVQNPHIERLRTHsIESSGKLKIsPEQHWDFtAEDLkDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLkENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDsIAKtRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPAtPssPMYVD
MKK4 rat MAAPSPSGGGGSGGG--GGTPGPIGPPASGHPAVSSMQG-----------KRKALKLNFANPPVKSTArFTLNPNTTGVQNPHIERLRTHSIESSGKLKIsPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVkRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKyVySVLDDVIPEEILGKITLATVKALNHLkENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKtRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPAtPSSPMYVD
  ***************..:*****:*:**:**********           *************:***********:********************************************************************************************************************************************************************************************************************************************************************************************************************:*************************
Consensus MAAPSPSGGGGSGGGSGGGTPGPIGPPAPGHPAVSSMQG-----------KRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.