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Chk2 human	---MSRESDVEAQQsHGsSACsQPHGsVtQsQGSSs------QsQGIsssststMPNSsQsSHsSSGTLSsLEtVstQELYsIPEDQEPEDQEPEEPTPAPWARLWALQDGFANL-------------------------------------------ECVNDNYWFGRDksCEYCFDEPLLkRTDKYRTYsKKHFRIFREVGPKNSyIAYIEDHsGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLtVDDQsVYPKALRDEYIMSktLGSGACGEVkLAFERKTCKKVAIkIISKRKFAIGsAREADPALNVETEIEILKkLNHPCIIkIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHskILGEt T378-p T378-gl sLMRtLCGtPtyLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRtQVsLkDQITSGkYNFIPEVWAEVsEkALDLVKKLLVVDPk K472-m1 K472-ub ARFTTEEALRHPWLQDEDMKRkFQDLLSEENESTALPQVLAQPstSRkRPREGEAEGAETTKRPAVCAAVL
Chk2 iso9 human	---MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSS------QSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLETESGHVTQSDLELLLSSDPPASASQSAGIRGVRHHPRPVCSLKCVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Chk2 iso11 human	---MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSS------QSQGISSSSTSTMPNSSQSSH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSSGTLSSLETVSTQELYSIPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Chk2 iso12 human	---MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSS------QSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANL-------------------------------------------ECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV-----------------------------QITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Chk2 mouse	MKSHHQSHSSTSSKAHDSASCSQSQGGFSQPQGTPSQLHELSQYQGSSSSSTGTVPSSSQSSHSSSGtLSSLETVStQELCSIPEDQ-----EPEEPGPAPWARLWALQDGFSN-------------------------------------------LDCVNDNYWFGRDKSCEYCFDGPLLRRTDKYRTYSKKHFRIFREMGPKNCYIVYIEDHSGNGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDAEDYYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGEtsLMRTLCGtPTYLAPEVLVSNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALNHPWLQDEYMKKKFQDLLVQEKNSVTLPVAPAQT-SSQKRPLELEVEGMPSTKRLsVCGAVL
Chk2 rat	-MKSHQSHGSTSSKAHDSASCSQSQGGFSQSQGTPSQLHDLSQYQGASSSSTSTVPSSSQSSHSSSGTLSSLETVSTQELCSIPEDQ-----EPEEPGPTPWARLWALQDGFSN-------------------------------------------LDCVNDNYWFGRDKSCEYCFDGPLLKRTDKYRTYSKKHFRIFREMGPKNCYIVYLEDHSGNGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSKTLGSGACGEVKMAFERKTCKKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDVEDYYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLISNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNLIPEVWTDVSEKALDLVKKLLVVDPKARLTTEEALSHPWLQDEHMKKKFQDLLVQEKNLVPLPLAPAQT-SGQKRPLELEAEDAESSKRLAVCKAVL
	::::::::::::*:*::***::*:::*:**::*... ..*:**:*****:*:*:******:::::::::::::::::.::::::.....:::::.::::::::::::::::.                                          ..:::::::::::::::::::.::::::::::::::::::::::.::::.:::::::::::::::::::.:::::.::.:::::::::.:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::.::.:::::::.:..::::::::::::::::::::..::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::*::*:::*::::::*::****:*:*****:*************************:***************:*****::***:****************:******:*******:**:******::*:::::**:::**:::::***:*:*:*:::::**::**:***
Consensus	---MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSS------QSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANL------------------------------------------LDCVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL