Multiple Sequence Alignment:
p53 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400)
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p53 human ---MEEPQsDPsVEPPLsQEtFsDLWkLLPENNVLsPLPsQ---AMDDLMLsPDDIEQWFtEDPGPDEAPRMPEAAPPVAPAPAAPtPAAPAPAPSWPLSSSVPsQkTYQGsYGFrLGFLhSGTAkSVTCTySPALNkMFCQLAkTCPVQLWVDstPPPGtRVRAMAIYkQSQHMTEVVRRCPHHERCsDSDGLAPPQHLIRVEGNLRVEYLDDrNtFrHsVVVPyEPPEVGSDCTTIHYNYMCNSSCMGGMNRrPILTIITLEDSSGNLLGRNsFEVRVCACPGRDRRtEEENLrkkGEPHHELPPGStkRALPNNt-SssPQPkkkPLDGEyFTLQIrGrErFEMFRELNEALELkDAQAGkEPGGsRAHsSHLkskkGQstsRHkkLMFktEGPDsD
p53 iso2 human ---MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQ---AMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNT-SSSPQPKKKPLDGEYFTLQDQTSFQKENC----------------------------------------------------
p53 iso4 human ---------------------------------------------MDDLMLsPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNT-SSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKkGQSTSRHKkLMFKTEGPDSD
p53 mouse MTAMEEsQsDIsLELPLsQEtFsGLWKLLPPEDILPs-----PHCMDDL-LLPQDVEEFF---EGPsEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAkSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGsRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEyTTIHyKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKkEVLCPELPPGsAkRALPTCT-SAsPPQkkkPLDGEyFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLkTkkGQsTsRHkkTMVkkVGPDsD
p53 iso2 mouse MTAMEESQSDISLELPLsQETFSGLWKLLPPEDILPS-----PHCMDDL-LLPQDVEEFF---EGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQkTYQGNYGFHLGFLQSGTAkSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYkkSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCT-SASPPQKkKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSLQPRAFQ--------ALIkEEsPNC-
p53 rat ---MEDsQsDMsIELPLsQEtFsCLWKLLPPDDILPTTATGsPNSMEDL-FLPQDVAELL---EGPEEALQVS-APAAQEPGTEAPAPVAPASATPWPLSSSVPSQKTYQGNYGFHLGFLQSGTAkSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEEHCPELPPGSAKRALPTST-SSsPQQKKKPLDGEYFTLKIRGRERFEMFRELNEALELKDARAAEESGDSRAHSSYPKTKkGQSTsRHkkPMIKKVGPDsD
p53 rabbit ---MEESQSDLSLEPPLSQETFSDLWKLLPENNLLTTSLNP---PVDDL-LSAEDVANWLNEDPEE--GLRVPAAPAPEAPAPAAPALAAPAPATSWPLSSSVPSQKTYHGNYGFRLGFLHSGTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPCPELPPGSSKRALPTTTTDSSPQTKKKPLDGEYFILKIRGRERFEMFRELNEALELKDAQAEKEPGGSRAHSSYLKAKKGQSTSRHKKPMFKREGPDSD
p53 green monkey ---MEEPQSDPSIEPPLsQETFSDLWKLLPENNVLsPLPSQ---AVDDLMLsPDDLAQWLTEDPGPDEAPRMSEAAPHMAPTPAAPTPAAPAPAPSWPLSSSVPSQKTYHGSYGFRLGFLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPCHELPPGSTkRALPNNT-SSsPQPkKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGkEPAGSRAHSSHLkSkkGQSTSRHkkFMFkTEGPDsD
     :::::::.:.::::::::::.:::::::.:.:...... . .::**.::::*:::::...:::.:::::::*:::.:*::::*:::***:*::*****:*******:*:***:****:*******:****:.***:**************::***:*:*********:*******************:***************:::**::**:**************:**::*****:********************************:********************:***:::::******:*****:.* ::**::**********:*::::::::*::::::::::::::.:.:::::::::::..:.:::::::::::.:.:.::::::
Consensus ---MEESQSDPSLEPPLSQETFSDLWKLLPENNILPPLPSQ---AMDDLMLSPDDVEQWFTEDPGPDEALRMPEAAAPQAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGNYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPCHELPPGSTKRALPNNT-SSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.