Multiple Sequence Alignment:
MYPT1 Download MSA
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MYPT1 human MKMADAKQkRNEQLKRWIGsEtDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINyANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWtPLHAAAHWGkEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQkkQNLLHsEKRDKKsPLIEsTANMDNNQsQKTFKNKETLIIEPEKNASRIEsLEQEKVDEEEEGKKDESSCSSEEDEEDDsESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQAtPtsPIKKFPttAtKIsPKEEERKDEsPATWRLGLRktGsyGALAEItASkEGQkEKDtAGVTRsAssPRLsssLDNKEKEKDsKGTRLAyVAPtIPRRLAstsDIEEKENRDS--SSLRTsSSYtRRKWEDDLKkNssV----NEGstyHksCsFGRRQDDLISSSVPSTtSTPtVTsAAGLQKsLLSSTSTTTKITTGSSSAGTQsstSNRLWAEDsTEKEKDSVPTAVtIPVAPTVVNAAAS-TTtLTTTtAGTVSSTTEVRERRRsyLtPVRDEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRstRtREQENEEKEKEEKEKQDKEKQEEkKESEtsREDEykQKysRtyDEtyQRyRPVSTSSSTTPs-SSLSTMSSsLyAssQLNRPNsLVGITSAysRGITKENEREGEKREEEKEGEDKSQPKsIRERRRPREKRRstGVsFWtQDsDENEQEQQsDtEEGsNKKETQtDsIsRyEtss--TsAGDRyDsLLGRsGsysyLEERKPyssRLEKDDSTDFKKLyEQILAENEkLKAQLHDTNMELTDLKLQLEKATQRQERFADRsLLEMEKRERRALERRIsEMEEELkMLPDLkADNQRLKDENGALIRVISKLsK
MYPT1 iso2 human MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDS--SSLRTSSSYTRRKWEDDLKKNSSV----NEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAAS-TTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPS-SSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSS--TSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKK-----------------------------------RQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
MYPT1 iso3 human
MYPT1 iso4 human MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDS--SSLRTSSSYTRRKWEDDLKKNSSV----NEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQ------------------------------------------------------------SRsYLtPVRDEESEsQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPS-SSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSS--TSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
MYPT1 mouse MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERVMLRDARQWLNSGHISDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMETVNKVGQTAFDVADEDILGYLEELQkkQTLLHSEKRDKKsPLIEStANMENNQPQKAFKNkETLIIEPEKNASRIEsLEHEKADEEEEGKKDEssCSSEEDEEDDSEsEAEtDKTKPMASVsNAHTSSTQAAPAAVTAPTLSSNQGTPTSPVKKFPISTTKIsPKEEERKDESPASWRLGLRKtGsyGALAEISASKEAQKEKDtAGVMRSAssPRLSSsLDNKEKEKDNKGTRLAyVtPTIPRRLAstsDIEEKENRES--SsLRTsssYTRRKWEDDLKKNSsI----NEGSTyHRSCsFGRRQDDLIsCsVPStTSTPTVTsAAGLQRSLPSstsTAAKtPPGSsSAGTQSSTSNRLWAEDstEKEKDSAPTAVTIPVAPTVVNAAAPSTTTLTTTTAGTV---SEVRERRRsYLTPVRDEESESQRKARSRQARQSRRstQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESEASREDEYKQKySRTyDETyTRyRPVSTSSSSAPSSSSLSTLGStLYASSQLNRPNsLVGITSAYSRGLAkENEREGEKKEEEKEGEDKsQPKsIRERRRPREKRRstGVSFWTQDsDENEQERQsDtEDGSsKRETQTDSVSRYDsSS--TSSSDRyDsLLGRsAsySYLEDRKPySSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSQLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLkDENGALIRVIsKLSK
MYPT1 rat MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHISDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMETVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKsPLIESTANMENNQPQKTFKNKETLIIEPEKNASRIESLEQEKADEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPMASVTNAHTASTQAAPAAVTTPTLSSNQGTPTSPVKKFPTSTTKIsPKEEERKDEsPASWRLGLRKtGsyGALAEITASKEAQKEKDTAGVIRSASsPRLSSSLDNKEKEKDNKGTRLAYVAPTIPRRLGstsDIEEKENRES--SNLRTSSSYTRRKWEDDLKKNSSI----NEGSTYHRSCSFGRRQDDLISCSVPSTTSTPTVTSAAGLQKSFLSSTSTTAKTPPGSsPAGTQSSTSNRLWAEDsTEKEKDSAPTAATILVAPTVVSAAASSTTALTTTTAGTLSSTSEVRERRRsYLTPVRDEESESQRKARSRQARQSRRstQGVTLTDLQEAEKTIGRSRSTRTREQENEEKDKEEKEKQDKEKQEEKKESEVSREDEYKQKYSRTYDETYARYRPVSTSSSSTPSSSSLSTLGSSLYASSQLNRPNSLVGITSAYSRGLTKDNEREGEKKEEEKEGEDKSQPKSIRERRRPREKRRstGVSFWTQDsDENEQERQsDTEDGSSKRDTQTDSVSRYDSSS--TSSSDRYDSLLGRSAsYSYLEERKPYGSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLkDENGALIRVISKLSK
MYPT1 pig MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKREKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDDEEEGKKDESSCSSEEDEEDDSESEAETDKTKPMAPVTNANTSSTQAAPVAVTTPTLSSGQATPTSPIKKFPTPATKISPKEEERKDESPASWRLGLRKTGSYGALAEITASKEAQKEKDTAGVIRSASSPRLSSSLDNKEKEKDNKGTRLAYVAPTIPRRLASTSDMEEKENRDS--LGLRTSSSYTRRKWEDDLKKNSSI----NEGSTYQKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKGLLSSTSTTTKITTGSSSAGTQSSTSNRVWAEDSTEKDKDSVPTALTVPVAPAVVNAAAA-TTTLTTTTAGTVSSTSEVRERRRSYLTPVRDEESESQRKARSRQARQSRRStQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTFDETYQRYRPASTSGSATPS-SSLSTMSSSLYASSQLNRPNSLVGITSAYSRGST-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
MYPT1 chicken MKMADAKQKRNEQLKRWIGSETDLEPPVVKRKKTKVKFDDGAVFLAACSSGDTEEVLRLLERGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEYLISQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQARYDVNIKDYDGWTPLHAAAHWGKEEACRILVENLCDMEAVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKREKKSPLIESTANLDNNQTQKTFKNKETLIMEQEKNASSIESLEHEKADEEEEGKKDESSCSSEEEEDDDSESEAETDKAKTLANANTT-----STQSASMTAPSVAGGQGTPTSPLKKFPTSTTKVSPKEEERKDESPASWRLGLRKTGSYGALAEITASKEAQKEKDSAGVIRSASSPRLSSSLDNKEKEKDGKGTRLAYVAPtIPRRLASTSDIDEKENRDSSASSIRSGSSYARRKWEEDVKKNSLNEGPTSLNTSYQRSGSFGRRQDDLVSSNVPSTAS--TVTSSAGLQKTLPASANTTTKSTTGSTSAGVQSSTSNRLWAEDSTEKEKDSVPTAVTVPVAPSVVNAAAT-TTAMTTATSGTVSSTSEVRERRRsYLTPVRDEESESQRKARSRQARQSRRstQGVTLTDLQEAEKtIGRSRStRTREQENEEKEKEEKEKQDKEKQEEKKESET-KDDDYRQRYSRTVEEPYHRYRPTSTSTST-SSTSSLSTSTSSLSSSSQLNRPNSLIGITSAYSRSGTKESEREGGKKEEEK-EEDKSQPKSIRERRRPREKRRstGVSFWTQDSDENEQEHQSDSEEGTNKKETQSDSLSRYDTGSLSVSSGDRYDSAQGRSGSQSYLEDRKPYCSRLEKEDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKTTQRQERFADRSLLEMEKRVSGKSQYLLGGKKSSRK--KDI-----------------------
MYPT1 cow MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKREKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDDEEEGKKDESSCSSEEDEEDDSESEAETDKTKPMASVTNANTSSTQAAPVAVTTPTVSSGQPTPTSPIKKFPASATKISPKEEERKDESPASWRLGLRKTGSYGALAEITASKEAQKEKDTAGVMRSASSPRLSSSLDNKEKEKDSKGTKLAYVTPTIPRRLASTSDIEEKENRDS--SSLRTSSSYTRRKWEDDLKKNSSI----NEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAAS-TTTLTTTTAGTVSSTAEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEK--EEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDEAYQRYRPVSTSSSTTPS-SLLSTMSSSLYASSQLNRPNSLVGITSAYSRGLTKENEREGEKKEEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKEVQTDSISRYEISS--TSASDRYDSLLGRSGSYSYSEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRTEDCTEKNRTKTHTEMQLLYSVKADNQRLKDENGALIRVISKLSK
  *******************************:*********************:***:**:**************************************************************:**:************************************************:**************:******************************:******************************:******:***************************:*******:***********::***:**:********:*:*****:*****:**:*:***************:*:***********:*::*:::::::::::::::::*:*:::::*:*****:****:::**:*************:*****************:****:*****:***.********************:***:****:*******:****::*****:*  :::*::***:*****:*:****::    :::::*::*:*********:*::****:*::****:****:::::*::*::*:::**::**:*:::::::::::::::::::::::::::::::::::::. ::::::::::::::::::::::*************************************************************::******************::::*:*:*:****::*:*:****:***:*:::* *:***::*:*::**********:********:.::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::.::::.::  ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::...:.:........:.:.:.:.:::::::::::::::::::::::
Consensus MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTSATKISPKEEERKDESPASWRLGLRKTGSYGALAEITASKEAQKEKDTAGVIRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDS--SSLRTSSSYTRRKWEDDLKKNSSI----NEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAAS-TTTLTTTTAGTVSSTSEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPS-SSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKKEEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSS--TSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.