(        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670       680       690       700       710       720       730       740       750       760       770       780       790         )
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GR human	MDSKEsL-TPGREENPSSVLAQERGDVMDFyKtLrGGAtVKVSAssPSLAVASQsDsk K57-ub K57-sm QRRLLVDFPk K67-ub K67-sm GSVSNA--------------------QQPDLsKAVSLSMGLyMGEtEtkVMGNDLGFPQQGQISLSSGETDLKLLEEsIANLNRstsVPENPkSSASTAVSAAPTEk K154-ac K154-ub EFPKTHSDVsSEQQHLkGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGsPGkEtNEsPWRSDLLIDENCLLsPLAGEDDsFLLEGNsNEDCKPLILPDTkPKIKDNGDLVLssPSNVtLPQVk K277-ub K277-sm TEkEDFIELCtPGVIk K293-ub K293-sm QEkLGTVyCQAsFPGANIIGNKMsAISVHGVSTSGGQMYHYDMNTASLSQQQDQkPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFsNGYSSPSMRPDVSsPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEG-QHNYLCAGRNDCIIDKIRRKNCPACRYRkCLQAGMNLEARkTkkKIk K498-ub K498-sm GIQQATTGVsQETSENPGNKtIVPAtLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDStWRIMTtLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMtLLQYSWMFLMAFALGWRSYRQSsANLLCFAPDLIINEQRMtLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKtLLLLSSVPkDGLk K681-ub K681-sm sQELFDEIRMTYIkELGkAIVkREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMsIEFPEMLAEIITNQIPKYSNGNIkkLLFHQK
GR iso2 human	MDSKESL-TPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNA--------------------QQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEG-QHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHENVMWLKPESTSHTLI-----------------------------------
GR iso3 human	MDSKESL-TPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNA--------------------QQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
GR iso10 human	MDSKESL-TPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNA--------------------QQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIA--------------------------SLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEG-QHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
GR mouse	MDSKESLAPPGRDEVPSSLLGRGrGSVMDLYKTLrGGATVKVsASsPSVAAASQADSKQQRILLDFSKGSASNAQQQ------------QQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLlEESIANLNRSTSRPENPKSSTPAAGCAtPtEKEFPQtHsDPSSEQQNRKSQPGTNGGSvKLYTTDQSTFDILQDLEFSAGSPGKETNESpWRSDLLIdEN-LLSPLAGEDDPfLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPsSVaLPqvKteKDDFIELCTpGVIKQEKLGPVYcQASFSGTNIIGNKmSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSS-TAtGPPPKLCLVCSDEaSVCHYGVLTCGSCKVFFKRAVEG-QHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGvSQDTSENA-NKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
GR rat	MDSKESLAPPGRDEVPGSLLGQGrGSVMDFYKSLRGGATVKVSASSPSVAAASQADSkQQRILLDFSkGSTSNVQQRQQQQQQQQQQQQQQQQQQQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTsVPENPKSSTSATGCAtPTEKEFPKtHSDASSEQQNRKSQTGTNGGSVKLYPTDQSTFDLLKDLEFSAGsPSKDTNEsPWRSDLLIDEN-LLsPLAGEDDPFLLEGNTNEDCKPLILPDTKPKIkDTGDTILssPSSVALPQVkTEKDDFIELCTPGVIkQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSsPGMRPDVSSPPSSSS-AATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEG-QHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVsQDTSENP-NKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAILGLRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGNLLCFAPDLIINEQRMSLPCMYDQCKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVkREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
	*******.:***:*:*:*:*:::**:***:**:***************:*:***:****:*:*:**:***:**:..             .....:*****************************:*****::*******::**************:*******::::::*:*******:****:*****::*:*:*****:****:*******:*:*****:***:*:***************:**********:*****::****************:*:**::*****:*:********:*****************:*******:*:***:::::::::::::::::::::::::::**********:*********************:*:*****::**:**:*********:*************:::****************:********************* *****************************************************:****:****::*******:*******************************:*************************:*:*******************************:*:****************:************::*:**:***********************:************************************************::*::*:.::::::*::::::::::::::::::::::::::::::::::::
Consensus	MDSKESL-TPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNA--------------------QQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEG-QHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK