Multiple Sequence Alignment:
MCL1 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350  )
           |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |  
MCL1 human MFGLkRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEkEASARREIGGGEAGAVIGGSAGAsPPStLtPDSRRVARPPPIGAEVPDVTAtPARLLFFAPTRRAAPLEEMEAPAADAIMsPEEELDGyEPEPLGkRPAVLPLLELVGEsGNNtStDGsLPstPPPAEEEEDELYRQSLEIISRYLREQATGAkDTkPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRkLDIkNEDDVksLSRVMIHVFSD--GVTNWGRIVTLISFGAFVAkHLkTINQESCIEPLAESITDVLVRtkRDWLVkQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAyLIR
MCL1 iso2 human MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGWVCGVLPCRGPRR--WHQECAAGFCRCCWSRSWFGISNkIALL-------------------------------------------------------------------------------
MCL1 mouse MFGLRRNAVIGLNLYCGGASLGAGGGS--PAGARLVAEEA--KARRE-GGGE--------------AALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVsPEEELDGCEPEAIGkRPAVLPLLERVSEAAkSsGADGsLPStPPPPEEEEDDLYRQSLEIISRYLREQATGSkDSkPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIkNEGDVKSFSRVMVHVFKD--GVTNWGRIVTLISFGAFVAKHLkSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
MCL1 rat MFGLRRNAVIGLNLYCGGASLGAGGGS--PAGTRLAAEEA--KARRE-GGGE--------------AALLPGARVVARPPPVGAEDPDVTASAERRLLKSPGLLAVPPEEMAASA-AAIMSPEEELDGCEPEVLSKRPAVLPLLERVSEAAKSSGADGSLPStPPPPEEEDDELYRQSLEIISRYLREQATGSKDAKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSFSRVMTHVFKD--GVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  ****:**************:****:*:..::*:**:*:*:..:****.****..............::*:*::*:******:***:*****:::*:*.::*:::*:*:***:*:*::**:********:***:::**********:*:*:::::::**********:***:*:*******************:**:**:*::**::*:**********************::::::::::.::::.::::.::*.:  ::::*::*:::*:::::::::::..::::.::::::.::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
Consensus MFGLRRNAVIGLNLYCGGAGLGAGGGGATRAGGRLLAEEAEAKARREIGGGEAGAVIGGSAGASPPAALLPDARRVARPPPIGAEDPDVTASAARRLFKAPGRRAAPLEEMAAPAAAAIMSPEEELDGCEPEPLGKRPAVLPLLERVGEAANNSGADGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPLGRAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSFSRVMAHVFKD--GVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.