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CDC25A human	MELGPEPPHRRRLLFACsPPPASQPVVKALFGASAAGGLsPVTNLTVTMDQLQGLGSDyEQPLEVKNNSNLQRMGssEstDsGFCLDsPGPLDSKENLENPMRRIHsLPQkLLGCsPALkRSHsDsLDHDIFQLIDPDENKENEAFEFKk K150-ac K150-ub PVRPVsRGCLHSHGLQEGkDLFTQRQNsAPARMLsSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMR-TTNLDNRCkLFDsPSLCSSSTR---SVLKRPErsQEEsPPGSTKrRKsMsGASPkESTNPEKAHETLHQSLSLAssPKGTIENILDNDPRDLIGDFSkGYLFHTVAGkHQDLkyIsPEIMAsVLNGkFANLIkEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKkPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYkEFFMKCQSYCEPPSyRPMHHEDFKEDLKKFRTKSRtWAGEKsKREMYsRLKKL
CDC25A iso2 human	MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKEN----------------------------------------LSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMR-TTNLDNRCKLFDSPSLCSSSTR---SVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
CDC25A mouse	MELGPEPPHRRRLFFACSPTPAPQPTGKMLFGASAAGGLSPVTNLTVTMDQLEGLGSDCEK-MEVRNNSSLQRMGsSESTDSGFCLDSPGPLDSKENLEISLTRINSLPQKLLGCSPALKRSHsDSLDHDTFHLIDQDENKENEAFEFKKPIRPASR-----HIYEESKDPFTHRQNSAPARMLSSNES---ESGNFSPLFIPQSPVKATLSDEDDGFIDLLDGENMKNDEETPSCMASLWTAPLVMRRPANLADRCGLFDSPSPCGSSTR---AVLKRADRSHEEPPRGTK-RRKSVPSPVKAKADVPE-PAQLPSQsLSLMSSPKGTIENILDSDPRDLIGDFSKGYLFNTVSGKHQDLKYISPEIMASVLNGKFAGLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKNPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEkSKREMYSRLKKL
CDC25A rat	MELGPEPPHRRRLLFTCSPTPAPQPTGKVQFGASRAGGLSPVTNLTVTMDQLEGLGSDYEKPMDVRNSSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLRRINCLPQKLLGCSPALKRSHSDSLDHDIFQLIDQDENKENEAFEFKKPIRPASRGCLNAHVHEESKDPFTHRQNSAPARMLSSNESDISESGNFSPLFTPQSPVKASLSDEDDGFIDLLDGENLKNDEETPSCMSSLWTAPLVMRRPTNLADRCGLFDSPSPCSSTSSCSTRAVKRADRSHEESPRGTK-RRKSsEA-SPVKADVPE-PTQLPHQSLSLTSFPKGTIENIFHSDPRDLIGDFSKGYLFHTVSGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEEFLLKKPIVPADGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
	*************:*:***:**:**::*::****:*****************:*****:*::::*:*:*:*****************************::::**::***********************:*:***:******::::::::.::.::.....:...:.::.::.:::::::::*****::.:*:***:***:*****:*:********:*******:**:*******:**********.::**::**:******:*:*:::   :::**::**:**:*:*::.****..:.:::::::**.::::::*****:*:********:::***************:**:***********************:**********************************:****:****:******************************************************:****:********************************************
Consensus	MELGPEPPHRRRLLFACSPPPAPQPTGKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVRNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPLRRINSLPQKLLGCSPALKRSHSDSLDHDIFQLIDQDENKENEAFEFKKPIRPASRGCL--HGHEESKDPFTHRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVKATLSDEDDGFIDLLDGENLKNDEETPSCMASLWTAPLVMRRPTNLANRCGLFDSPSLCSSSTR---SVLKRADRSQEESPRGSKKRRKSMSGASPKEADNPEKAHQLLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL