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Caldesmon human	MDDFERRRELRRQ--KREEMRLEAERIAyQRNDDDEEEAARERRRRARQERLRQKQEEEsLGQVTDQVEVNAQNsVPDEEAKTTttNtQVEGDDEAAFLERLARREERRQKRLQEALERQkEFDPtITDAsLsLPSRRMQNDtAENETTEKEEKsESRQERyEIEETETVTkSyQkNDWRDAEENKKEDKEKEEEEEEkPKRGsIGENQVEVMVEEKTTEsQEE---TVVMSLKNGQISSEEPKQEEEREQGsDEISHHEKMEEEDKERAEAERARLEA--EERERIKAEQDKKIADERARIEAEEKAAAQERERRE-------AEERERMREEEK-RAAEERQRIKEEEK-RAAEERQRIKEEEKRAAEERQR------------IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQEtKIKGEKVEQKIEGKWVNEKKAQEDkLQTAVLKKQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEVkSFMDRKKGFTEVKsQNGE--FMTHKLKHtENtFsRPGGR-AsVDtKEAEGAPQVEAGkRLEELRRRRGEtEsEEFEKLKQKQQEAALELEELkKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLsDDKKPFKCFTPkGssLk K645-ac K645-sm IEERAEFLNk K655-ac K655-ub sVQKssGVKStHQAAIVskIDsRLEQyTsAIEGTksAKPtKPAASDLPVPAEGVRNIksMWEkGNVFssPtAAGtPNk K733-ac K733-ub EtAGLKVGVSsRINEWLTktPDGNksPAPKPsDLRPGDVsSk K775-m1 K775-ub RNLWEKQsVDKVtsPtKV--------------------
Caldesmon iso2 human	MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGsIGENQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE--FMTHKLKHTENTFSRPGGR-ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQyTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV--------------------
Caldesmon iso3 human	ML--GG----SGs--HGRRsLAALsQIAyQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGsIGENQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE--FMTHKLKHTENTFSRPGGR-ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV--------------------
Caldesmon iso4 human	MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKrGsIGENQI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE--FMTHKLKHTENTFSRPGGR-ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTsPTKV--------------------
Caldesmon iso5 human	ML--GG----SGS--HGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE--FMTHKLKHTENTFSRPGGR-ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV--------------------
Caldesmon iso6 human	MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGsIGENQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE--FMTHKLKHTENTFSRPGGR-ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKsVQK-SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV--------------------
Caldesmon mouse	MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEAHVQNSVPDEESKPASSNTQVEGDEEAALLERLARREERRQKRLQEALERQkEFDPTItDGsLSGPSRRMQNDsAENEtAEGEEKREsRsGRyEVEETEVVIKSYQKNsYQDAEDKKKEEKEEE--EQEKLkGGsLGENQVEKMVEEKTPEIQEE---AVLMVLENGQVSAEESKIEGDGEQDMEEIARRKKMGEEERERAEAERLRLEVEGQEQERIKAEQDRKLAEERARVEAEQKAAAEERERRE-------AEERERREAEER-ERREAE------------------------ERAEQAR------------IQEEQRRVAEAQKKAKAEEEEKARIEEQRQKQQLEEQRSEKREAKDKGEKGAEKADRKGVNEREAPDDRLQTAVPKTQEEEKGVKGQAQRQKPRDD-KPAFRKEEIKDEKIKKDKEPKEEVKSFLDRKKGFTEVKAQNGE--FMTHKLKQTENAFS--RSGGRAsGDKEAEGAPQVEAGKRLEELRRRRGEtENEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKAREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSsLKIEERAEFLNksVQK-SGVRSTHQAAVVSKIDSRLEQyTNAIEGTKASKPMKPAASDLPVPAEGVRNIKSMWEKGSVFsAPsAsGtPNKETAGLKVGVSSRINEWLtKsPDGNKsPAPKPSDLRPGDVSGkRNLWEKQsVDKVtsPtKV--------------------
Caldesmon iso5 mouse	--------MLSGSGsQGRRCLATLSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEAHVQNSVPDEESKPASSNTQVEGDEEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSGPSRRMQNDSAENETAEGEEKRESRSGRYEVEETEVVIKSYQKNSYQDAEDKKKEEKEE--EEQEKLKGGsLGEN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QIKDEKIKKDKEPKEEVKSFLDRKKGFTEVKAQNGE--FMTHKLkQTENAFsPsRSGGRAsGDKEAEGAPQVEAGkRLEELRRRRGEtENEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKAREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSSLKIEERAEFLNKSVQK-SGVRSTHQAAVVSKIDSRLEQYTNAIEGTKASKPMKPAASDLPVPAEGVRNIKSMWEKGSVFSAPSASGTPNKETAGLKVGVSSRINEWLTKSPDGNKSPAPKPSDLRPGDVSGKRNLWEKQSVDKVTSPTKV--------------------
Caldesmon rat	--------MLSRSGSQGRRCLATLSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEAHVQNSAPDEESKPATANAQVEGDEEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSVPSRRMQNNSAENETAEGEEkGESRSGRYEMEETEVVITSYQKNSYQDAEDKKKEEKEEE-EEEEkLKGGNLGEN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QIkDEKIKKDKEPKEEVKNFLDRKKGFTEVKAQNGE--FMTHkLKQTENAFsPSRSGGRAsGDkEAEGAPQVEAGkRLEELRRRRGETESEEFEKLKQKQQEAALELEELkKKREERRKVLEEEEQRRKQEEADRKAREEEEKRRLkEEIERRRAEAAEKRQKMPEDGLSEDKkPFKCFTPKGSSLkIEERAEFLNKSVQK-SGVKSTHQAAVVSkIDSRLEQYTNAIEGTKASkPMKPAASDLPVPAEGVRNIkSMWEKGSVFSsPSASGtPNKETAGLKVGVSSRINEWLTksPDGNKsPAPkPSDLRPGDVSGKRNLWEkQSVDKVTsPTKV--------------------
Caldesmon rabbit	MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVADQVEVHAQNSVSNEDSKPSTTSTQVEGDDEAALLERLARREERRQKRLQEALERQKEFDPTVTDASASLPSRRMPNDTAENATAEKEAKAESRRERYETVETKMVTKSEQKNDWRDAEDKKKDEKEREDGEEEKSKQESVGENQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKDEKIKKDKEAKEEVKSFMDRKKGFTDVKSQNGE--FMTHKLKHAENTFSPGRSG-A----RPSGDAQEAEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRKKQEEADRKVREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK-SGVKSTHQAAVVSKIDSRLEQYTSAIEGTKAAKSTKPAASDLPVPAEGVRNIKSMWEKGNVFSAPTASGTPNKETAGLKVGVSSRINEWLTKTPDGSKSPAPKPSDLRPGDVSGKRNLWEKQSVDKVTsPTKV--------------------
Caldesmon chicken	MDDFERRRELRRQ--KREEMRLEAERLsyQRNDDDEEEAARERRRRARQERLRQKEEGDVsGEVTEKSEVNAQNsVAEEETKR-------STDDEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSVPSRREVNNVEENEITGKEEKVETRQGRCEIEETETVTKSYQRNNWRQDGEEEGK-KEEKDSEEEKPKEVPTEENQVDVAVEKSTDKEEVVETKTLAVNAENDT------NAMLEGEQSITDA--------ADKEKEEAEKEREKLEAEEKERLKAEEEKKAAEEKQKAEEEKKA-AEERERAKAEEEKRAAEERERAKAEEERKAAEERERAKAEEERKAAEERAKA-EEERKAAEERAKAEEERKAAEERAKAEKERKAAEERERAKAEEEKRAA----------------EEKARLEA---EKLKEKKKMEEKKAQEEKAQANLLRKQEEDKEAKVEAKKESLPEKLQPTSKKDQVKD-NKDKEKAPKEEMKSVWDRKRGVPEQKAQNGERELtTPKLKsTENAFGRSNLKGAANA----------E-----------------AGSEKLKEKQQEAAVELDELKKRREERRKILEEEEQKKKQEEAERKIREEEEKKRMKEEIERRRAEAAEKRQKVPEDGVSEEKKPFKCFsPKGSsLKIEERAEFLNKsAQK-SGMKPAHttAVVsKIDsRLEQyTsAVVGNKAAKPAKPAAsDLPVPAEGVRNIKsMWEKGNVFSsPGGTGtPNKEtAGLKVGVSsRINEWLTKtPEGNKsPAPKPSDLRPGDVSGKRNLWEKQsVEKPAASSSKVTATGKKSETNGLRQFEKEP
Caldesmon cow	MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEEALGQVTDQVEVNTQNSVPDEEVKTTTTNTQAEGDDEAALLERLARREERRQKRLQEALERQKEFDPTITDASLSLSSRRMQNDTTDNETAEKEGRSESRQERQELEETEIVTKSHQKNDWMEAEEKKKEEKEKEEEEEEKPKPGSIEENQLKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKTKKD-KESKDVKRFLDAKKGFTEVKSQNGE--FMTHKLKHAENTFSRAGGR-VS-EAKEAEGTSQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRKKQEEAERKVREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSSLKIEERAEFLNKSVQK-SGVKPTHQAAVVSKIDSRLEQYTSAIEGTKAAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTASGTPNKETAGLKVGVSSRINEWLTKTPEGSKsPAPKPSDLRPGDVSGKRNLWEKQSVDKVTsPTKV--------------------
	:::::::::::::  :::::::::::::***************************:*::::*:*::::*:::***:::*::*::::::::::*:***:****************************:**:*:*::***::*::::*:::::*:::*:*::*:*.:**:.*::*:*:*::::::::::::**::.:*:**:*.::.:**:                                                                                                                                                                                                                                                               .................. ........:::::::*::::::::*:::*:*:*::::*:****  ::*:***::**:*::::::.::.:.:::::::::*::::::::::::::::::::****:******:**:****:******:******::*****:**:******:*:*****************:****:*::*******:******************:**.**::::*::*:************:*::*:*::*::************************:***:*:::************************:*:*:****************:**********:*:::::::
Consensus	MDDFERRRELRRQ--KREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAALLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-K--K--A----------P---K-EIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE--FMTHKLKHTENTFSRPGGR-ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK-SGVKSTHQAAIVSKIDSRLEQYTSAIEGTKAAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSGKRNLWEKQSVDKVTSPTKV--------------------