Multiple Sequence Alignment:
Tau Download MSA
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Tau human MAEPRQEFEVMEDHAGTyGLGDRKDQGGYTMHQDQEGDtDAGLKEsPLQtPTEDGsEEPGsETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPG----------PPGLSHQLMSGMPGAPLLPEGPREATRQPsGtGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDsPPSKAsPAQDG-------RPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRA-KGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGE--GPEARGPSLGEDTKEADLPEPsEKQPAAAPRGKPVsRVPQLKARMVSKSKDGtGsDDKKAKTSTRSSAKTLKNRPCLsPKHPTPGSSDPLIQPSSPAVCPEPPSSPK----YVSSVTSRtGsSGAKEMKLKGADGK--TKIATPRGAAPPGQKGQANATRIPAKtPPAPKtPPs------------------SGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPtREPKKVAVVRtPPKsPssAKsRLQTAPVPMPDLKNVKSKIGstENLKHQPGGGKVQIINKKLDLsNVQSKCGskDNIKHVPGGGsVQIVykPVDLsKVtSKCGsLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGsLDNITHVPGGGNkkIETHKLtFRENAKAKTDHGAEIVyKsPVVsGDtsPRHLsNVsstGsIDMVDsPQLAtLADEVSASLAKQGL
Tau iso2 human MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLK----------------------------------------------------------AEEAGIGDTPsLEDEAAGHVTQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVSKsKDGtGSDD----------------------------------------------------------------------KKAKGADGK--TKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPS------------------SGEPPKSGDRSGYSSPGSPGTPGSRSRTPsLPTPPTREPKKVAVVRtPPKsPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG-------------------------------KVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGsLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKsPVVSGDTsPRHLsNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Tau iso3 human ----------------------------------------------------------------------------------------------MLRALQQRKREAGIGDTPSLEDEAAGHVTQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVSKsKDGtGSDD----------------------------------------------------------------------KKAKGADGK--TKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPS------------------SGEPPKSGDRSGYssPGsPGTPGSRSRTPSLPTPPTREPKKVAVVRtPPKsPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG-------------------------------KVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKsPVVSGDTsPRHLsNVSsTGSIDMVDsPQLATLADEVSASLAKQGL
Tau iso4 human MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAE-----------------------------AEEAGIGDTPSLEDEAAGHVTQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVSKSKDGTGSDD----------------------------------------------------------------------KKAKGADGK--TKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPS------------------SGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG-------------------------------KVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Tau iso5 human MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPsLEDEAAGHVTQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVSKsKDGtGSDD----------------------------------------------------------------------KKAKGADGK--TKIATPRGAAPPGQKGQANATRIPAKTPPAPKtPPs------------------SGEPPKSGDRsGYssPGsPGtPGSRSRTPSLPTPPTREPKKVAVVRtPPKsPSSAKSRLQTAPVPMPDLKNVKSKIGsTENLKHQPGGG-------------------------------KVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGsLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKsPVVsGDTsPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Tau iso6 human MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLK----------------------------------------------------------AEEAGIGDTPsLEDEAAGHVTQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVSKsKDGtGSDD----------------------------------------------------------------------KKAKGADGK--TKIATPRGAAPPGQKGQANATRIPAKTPPAPKtPPS------------------SGEPPKSGDRSGYSSPGsPGtPGSRSRTPSLPTPPTREPKKVAVVRtPPKsPSSAKSRLQTAPVPMPDLKNVKSKIGsTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGsLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKsPVVSGDTsPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Tau iso7 human MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKsTPTAE-----------------------------AEEAGIGDtPsLEDEAAGHVTQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVSKsKDGtGSDD----------------------------------------------------------------------KKAKGADGK--TKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPS------------------SGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Tau iso8 human MAEPRQEFEVMEDHAGtyGLGDRKDQGGyTMHQDQEGDtDAGLkEsPLQtPtEDGsEEPGSETSDAKstPtAEDVTAPLVDEGAPGKQAAAQPHtEIPEGttAEEAGIGDtPsLEDEAAGHVtQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVSKsKDGtGSDD----------------------------------------------------------------------KKAKGADGK--TKIAtPRGAAPPGQkGQANAtRIPAktPPAPktPPs------------------SGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPtREPKKVAVVRtPPKsPssAKsRLQtAPVPMPDLkNVKsKIGstENLkHQPGGGkVQIINkkLDLsNVQskCGsKDNIKHVPGGGsVQIVykPVDLsKVTskCGsLGNIHHKPGGGQVEVksEKLDFKDRVQskIGsLDNItHVPGGGNKKIEtHKLtFRENAKAKtDHGAEIVyKsPVVsGDtsPRHLsNVsstGsIDMVDsPQLAtLADEVsAsLAKQGL
Tau mouse MADPRQEFDTMEDHA-----------GDYTLLQDQEGDMDHGLKEsPPQPPADDGAEEPGSEtsDAKstPTAEDVTAPLVDERAPDKQAAAQPHTEIPEGITAEEAGIGDtPNQEDQAAGHVTQ----------------GRREGQAPDLGTSDWTRQQVSSMSGAPLLPQGLREATCQPSGTRPEDIEKSHPASELLR---------RGPPQKEGWGQDRLGsEEEVDEDLTVDESSQD-SPPSQASLTPGRAAPQAGS---GSVCGETASVPGLPTEGSVPLPADFFSKVSAETQASQPEGPGTGPMEEGHEAAPEFTFHVEIKASTPKEQD-----LEGATVVGVPGEEQKAQTQGPSVGKGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKARVA--SKDRTGNDEKKAKTSTPSCAKAPSHRPCLSPTRPTLGSSDPLIKPSSPAVSPEPATS---PKHVS-SVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAAsPAQKGtSNATRIPAKttPsPKtPPGs------------------GEPPKsGERsGyssPGsPGtPGsRsRtPsLPtPPtREPKKVAVVRtPPKsPsAsKSRLQTAPVPMPDLkNVRSkIGstENLKHQPGGGKVQIINKkLDLSNVQskCGsKDNIKHVPGGGsVQIVykPVDLSKVTSkCGsLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGsLDnITHVPGGGNkKIETHKLtFRENAKAKTDHGAEIVyKsPVVsGDtsPRHLsNVsstGsIDMVDsPQLATLADEVSASLAKQGL
Tau iso3 mouse MADPRQEFDTMEDHA-----------GDYTLLQDQEGDMDHGLKESPPQPPADDGAEEPGSETSDAKSTPTAEDVTAPLVDERAPDKQAAAQPHTEIPEGITAEEAGIGDtPNQEDQAAGHVTQ----------------ARVA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKDRTGNDE----------------------------------------------------------------------KKAKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGS------------------GEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Tau iso7 mouse ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-------------DPRQEFDTME--------DHAG---------------------DYTLLQDQEGDMDHGLKAEEAGIGDtPNQEDQAAGHVTQARVASKDRTGNDEKKAKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKtPPGSASKQPQRKLPPAGAKSERGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Tau rat MAEPRQEFDTMEDQA-----------GDYTMLQDQEGDMDHGLKEsPPQPPADDGSEEPGsETSDAKStPtAEDVTAPLVEERAPDKQATAQSHTEIPEGTTAEEAGIGDTPNMEDQAAGHVTQEPQKVEIFSQSLLVEPGRREGQAPDSGISDWTHQQVPSMSGAPLPPQGLREATHQPLGTRPEDVERSHPASELLW---------QEsPQKEAWGKDRLGsEEEVDEDITMDESSQE-SPPSQASLAPGTATPQARSVSASGVSGETTSIPGFPAEGSIPLPADFFSKVSAETQASPPEGPGTGPSEEGHEAAPEFTFHVEIKASAPKEQD-----LEGATVVGAPAEEQKA--RGPSVGKGTKEAsLLEPTDKQPAAGLPGRPVSRVPQLKARVAGVSKDRTGNDEKKAKTSTPSCAKTPSNRPCLSPTRPTPGSSDPLIKPSSPAVCPEPATSPK----YVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGTSNATRIPAKtTPsPKtPPGS------------------GEPPKSGERSGyssPGsPGtPGsRSRtPsLPtPPTREPKKVAVVRtPPKsPSASKsRLQTAPVPMPDLkNVRSKIGsTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVHIVYKPVDLSKVTSKCGsLGNIHHKPGGGQVEVKSEkLDFkDRVQSKIGsLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVyKsPVVsGDtsPRHLSNVssTGsIDMVDsPQLATLADEVSASLAKQGL
Tau cow MAEPRQEFDVMEDHAQ----------GDYT-LQDQEGDMDPGLKESPLQTPADDGSEEPGSETSDAKSTPTAEDATAPLVDEGAPGEQAAAQAPAEIPEGTAAEEAGIGDTSNLEDQAAGHVTQARMV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKGKDGTGPDDKKTKGA--------------------------------------------------------------------DGKPG--TKIATPRGAAPPGQKGQANATRIPAKTTPTPKTSPATM--QVQKKPPPAGAKSERGESGKSGDRsGYSSPGsPGtPGSRSRTPSLPTPPTREPKKVAVVRTPPKsPSAAKSRLQAAPGPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKsPVVSGDTsPRHLSNVSSTGsIDMVDSPQLATLADEVSASLAKQGL
  :::::::::::::::...........::::.::::::::::::::::.:.:..::.:::::::::::::::::.............................:::::::::::::::::::::::                                                                                                                                                                                                                                                                               :.:::::*::*:::                                                                      :::::::::  :*********:*:***::*********:*:***:*:                  .**::***:********************************************::*****:**:********:****************::::::::::::::::::::::::::::::::*:**************************************************************************************************************************************
Consensus MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDE-AP-KQAAAQ-HTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMVSKSKDGTGSDD----------------------------------------------------------------------KKAKGADGK--TKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPS------------------SGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.