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ADAM12 human	MAARPLP-VSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNrFVEEGEECDCGEPEECMNrCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKG-LMRKPPDsyPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWEtGLRLAPLRPAPQyPHQVPRSTHTAYIK
ADAM12 mouse	MAERPARRAPPARALLLALAGALLAPRAARGMSLWDQRGTYEVARASLLSKDPGIPGQSIPAKDHPDVLTVQLQLESRDLILSLERNEGLIANGFTETHYLQDGTDVSLTRNHT---DHCYYHGHVQGDAASVVSLSTCSGLRGLIMFENKTYSLEPMKNTTDSYKLVPAESMTNIQGLCGSQHNKSNLTMEDVSPGTSQMRARRHKRETLkMTkYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDIDKCSISQDPFTSLHEFLDWRKIKLLPRKSHDNAQLISGVYFQGTTIGMAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNPSTGFPFPMVFSSCSRKDLEASLEKGMGMCLFNLPEVKQAFGGRKCGNGYVEEGEECDCGEPEECTNRCCNATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDLPEFCTGTAPHCPANVYLHDGHPCQGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKSAFAKCELRDAKCGKIQCQGGASRPVIGTNAVSIETNIPQQEGGRILCRGTHVYLGDDMPDPGLVLAGTKCAEGKICLNRRCQNISVFGVHKCAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTVGILVSILCLLAAGFVVYLKRKTLMRLLFTHkKTTMEkLRCVHPSRTPsGPHLGQAHH-TPGKGLLMNRAPHFNTPKD--RHSLKCQNMDISRPLDARAVPQLQSPQRVLLPLHQTPRAPSGPARPLPASPAVRQAQGIRKPsPPQKPLPADPLSRTSRLTSALVRTPGQQEPGHRPAPIRPAPK--HQVPRPSHNAyIK
ADAM12 rat	MAERPARRAPPARALLLALAGALLAPRAARGVSLWDQRGAYEVAKASLLTKDPGSPGQSIPAKDHPDVLTVQLQLESRELILSLERNEGLIANGFTETHYLQDGSDVSFTRNYT---DHCYYHGHVQGDAASVVSLSTCSGLRGLIVFENKTYILEPMKNTTDRYKLVPAENMKNIQGLCGSHHNKSSLTMEDVFPEPSQMWGRRHKRETLKMTKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDIDKCSISQDPFTSLHEFLDWRKLKLLPRKSHDNAQLISGVYFQGTTIGMAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNPSTGFPFPMVFSSCSRKDLEASLEKGMGMCLFNLPEVKQAFGGRKCGNGYVEDGEECDCGEPEECTNRCCNATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDLPEFCTGTAPHCPANVYLHDGHPCQGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKSSFVKCELRDAKCGKIQCQGGASRPVIGTNAVSIETNIPQQEGGRILCRGTHVYLGDDMPDPGLVLAGTKCAEGKICLNRQCQNISVFGVHKCAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTVGILVSVLCLLAAGFVVYLKRKTLMRLLFTHKKNTMEKLRCVHTSRTPSGPRPGQAHH-ILGKGPLMSRPPHFNTTKD--RHSLKCQNIDISRPLNARVVPQPQSPQRVLLPLHQAPRAPSGPARPLPANPAVRQAQGTHKPSPPQKPLPADPLSRTSRLTGALVRTPGQQESGHRPAPIRPAPK--HQVPRLSHNAYIK
	**:**:::::****************::***:***:*::::**:.**::::*:::*::*:::*:**:**:::**:**::**::*********::**********:***::**:*...:********:*:::*:*************:***::*.*****::*::***:**:.:::::*:***:**:::*::::*:*.:**:::*********:*********************************************************:****:****************.*************:*********************:****:******:***********************:*****:**:********:***:***************:*******:********:::***:****::**:************:********************:*********:*****:*************::*************:**:************************************************:***:*:***:*******************************:*:******************************:*******:**********:***************************************************:****::*****************:*****:**:*:******::**:*:*:.::***:..:***.**.::*:::::**..*::*:***.******::::***:**:****:***::*****:*******.**:*****:.**:***********:**:***.**:*****:*.*:*:**:****:..*****.:*:****
Consensus	MAERPARRAPPARALLLALAGALLAPRAARGVSLWDQRGAYEVARASLLSKDPGIPGQSIPAKDHPDVLTVQLQLESRELILSLERNEGLIANGFTETHYLQDGTDVSLTRNYT---DHCYYHGHVQGDAASVVSLSTCSGLRGLIVFENKTYILEPMKNTTDRYKLVPAENMKNIQGLCGSHHNKSNLTMEDVFPEPSQMWARRHKRETLKMTKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDIDKCSISQDPFTSLHEFLDWRKIKLLPRKSHDNAQLISGVYFQGTTIGMAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNPSTGFPFPMVFSSCSRKDLEASLEKGMGMCLFNLPEVKQAFGGRKCGNGYVEEGEECDCGEPEECTNRCCNATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDLPEFCTGTAPHCPANVYLHDGHPCQGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKSSFAKCELRDAKCGKIQCQGGASRPVIGTNAVSIETNIPQQEGGRILCRGTHVYLGDDMPDPGLVLAGTKCAEGKICLNRQCQNISVFGVHKCAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTVGILVSILCLLAAGFVVYLKRKTLMRLLFTHKKTTMEKLRCVHPSRTPSGPRPGQAHH-HLGKGLLMRRPPHFNTPKD--RHSLKCQNIDISRPLNARAVPQPQSPQRVLLPLHQAPRAPSGPARPLPANPAVRQAQGTRKPSPPQKPLPADPLSRTSRLTGALVRTPGQQEPGHRPAPIRPAPK--HQVPRLSHNAYIK