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ER-alpha human	MTMTLHtKAsGMALLHQIQGNELEPLNRPQLkIPLERPLGEVYLDssKPAVyNYPEGAAYEFNAAAAANAQ-----VYGQTGLPYGPGSEAAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNsDNRRQGGRERLAsTNDk K171-ac K171-m1 K171-m2 K171-sm GSMAMESAk K180-m2 K180-sm ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRsIQGHNDyMCPATNQCTIDKNRRKsCQACRLRkCyEVGMMk K252-ac K252-hy GGIRkDRrGGRMLk K266-ac K266-m1 K266-sm Hk K268-ac K268-sm RQRDDGEGrGEVGsAGDMRAANLWPsPLMIk K299-ac K299-sm RSk K302-ac K302-me K302-m1 K302-ub k K303-ac K303-ub NsLALSLtADQMVSALLDAEPPILYSEYDPTRPFSEAsMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGkLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEk K472-ac K472-sm DHIHRVLDKITDtLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLyDLLLEMLDAHRLHAPTsRGGAsVEETDQSHLATAGSTSsHsLQKYYITGEAEGFPAtV
ER-alpha mouse	MTMTLHTKAsGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPtVFNYPEGAAYEFNAAAAAAAA-ASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQLsPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRsNsDNRRQNGRERLSsSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRsIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGAsGDMRAANLWPsPLVIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYtFLSsTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATtSSTSAHSLQTYYIPPEAEGFPNTI
ER-alpha rat	MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAYEFNAAAAAAAAGASAPVYGQSSITYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPPHVsPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSSEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCyEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGTSGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKsIILLNSGVYTFLSsTLKSLEEKDHIHRVLDKINDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI
	********************************:*:**:*****:*:***:*:****************:*:.::::****::::**********::*:**:**:****************::****:***:***********:*:**::*******:*******:*****:*:::**:*:**************************************************************************************************:***:*:*::*************:**::****:*******************.:******:*********************************:**:***************************************************************************************************************:******************:************************:*************************:**:*:::**::*::*:*::***:****:***::******:*:
Consensus	MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAYEFNAAAAAAAA-ASAPVYGQSGIAYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPIIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQSQLATTSSTSAHSLQTYYIPPEAEGFPNTI