Multiple Sequence Alignment:
eIF2-alpha Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340   )
           |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |   
eIF2-alpha human MPGLSCRFYQHkFPEVEDVVMVNVRsIAEMGAYVSLLEYNNIEGMILLsELsRRRIRsINkLIRIGRNECVVVIRVDKEkGyIDLskRRVsPEEAIkCEDk
FTkSkTVYsILRHVAEVLEYTkDEQLESLFQrTAWVFDDk
Yk
RPGyGAyDAFk
HAVsDPSILDSLDLNEDEREVLINNINRRLtPQAVkIRADIEVACyGyEGIDAVkEALRAGLNCsTENMPIkINLIAPPRyVMTTTTLERtEGLSVLSQAMAVIkEKIEEkrGVFNVQMEPkVVtDtDEtELARQMERLERENAEVDGDDDAEEMEAkAED----------------------------
eIF2-alpha mouse MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELsRrrIRSINKLIRIGRNECVVVIRVDKEKGyIDLSKRRVSPEEAIKCEDkFTkSkTVYsILRHVAEVLEYTkDEQLESLFQRTAWVFDDk
YKRPGyGAyDAFKHAVsDPSILDsLDLNEDEREVLINNINRRLtPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIkEKIEEKRGVFNVQMEPKVVtDTDETELARQLERLERENAEVDGDDDAEEMEAKAED----------------------------
eIF2-alpha rat MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELsRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDkYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED----------------------------
eIF2-alpha rabbit -PGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGRILLsELsR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
eIF2-alpha fruit fly -MALTSRFYNERYPEIEDVVMVNVLSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGKTEPVVVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRHVADILGFEGNEKLEDLYQKTAWHFEKKYNNKT-VAYDIFKQSVTDPTVFDECNLEPETKEVLLSNIKRKLVSPTVKIRADIECSCYGYEGIDAVKASLTKGLELSTEELPIRINLIAPPLYVMTTSTTKKTDGLKALEVAIEHIRAKTSEYDGEFKVIMAPKLVTAIDEADLARRLERAEAENAQVAGDDDEEDGADQEGMQFDPEKEFNHKGSGAGRANEEDEEEEED
  .::*::***::::**:********:*********:*********:********:::::::::::.:..:.:::::::::::::::::::::::.:.::...::::::..:.:::::..:.....:.::.:.:.:::.:..::......::::::.::.::...:...:.....:::..::.:.:...:::::::::.:::::::::::::::.:::..:::..::.:::::::.:::::.:...:.::.::..:.:.:.::..:..:.:.:.::::.:::.:::.:::..::::::::.::::::::..::.:..                            
Consensus MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED----------------------------
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.