Multiple Sequence Alignment:
CREM Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360 )
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CREM human ----------------MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGSPAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKRREILSRRPsyRKILNELsSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETELAPSHMAAATGDMPTYQIRAPtAALPQGVVMAAsPGsLHsPQQLAEEAtRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY
CREM iso2 human MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQV-------------------------------------------------AAIAETDESAESEGVIDSHKRREILSRRPsYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQY---------------------------------------------------------------------------TATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY
CREM iso6 human MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGSPAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKRREILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQ------------AATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAARECRRKKKEYVkCLENrVAVLENQNkTLIEELkALkDLYCHKVE-
CREM iso8 human ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVT---GDDTDEEtELAPSHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAARECRRKKKEYVkCLENrVAVLENQNkTLIEELkALkDLYCHKVE-
CREM mouse MSKCGRKKYMRTNVRQMTMETVESQQDRSVTRSVAEHSSAHM--QTGQISVPTLAQVSVAGSGTGRGSPAVTLVQLPSGQTVQVQGVIQTPHPSVIQSPQIQTVQVATIAEtDDsADs-EVIDsHKRREILSRRPsYRKILNELssDVPGIPKIEEEKsEEEGTPPNIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETDLAPSHMAAATGDMPTYQIRAPTTALPQGVVMAAsPGSLHsPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD-
CREM iso2 mouse MSKCGRKKYMRTNVRQMTMETVESQQDRSVTRSVAEHSSAHM--QTGQISVPTLAQV-------------------------------------------------ATIAETDDSADS-EVIDSHKRREILSRRPsYRKILNELSSDVPGIPKIEEEKSEEEGTPPNIATMAVPTSIYQTSTGQYN---------------------------------------------------------------EETDLAPSHMAAATGDMPTYQIRAPTTALPQGVVMAAsPGsLHsPQQLAEEATRKRELRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELkALKDLYCHKAE-
CREM iso3 mouse MSKCGRKKYMRTNVRQMTMETVESQQDRSVTRSVAEHSSAHM--QTGQISVPTLAQV-------------------------------------------------ATIAETDDSADS-EVIDSHKRREILSRRPSYRKILNELSSDVPGIPKIEEEKSEEEGTPPNIATMAVPTSIYQTSTGQYN---------------------------------------------------------------EETDLAPSHMAAATGDMPTYQIRAPTTALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD-
  ::::.::::..::.:::::::::::.:.::::::::..:::...::::.::::::::.................................................::::::::::::..::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::................................................................:::.::::::::**************:****************************************:****:*********:******:***:*****::***::::*:: 
Consensus MSKCGRKKYMRTNVRQMTMETVESQQDRSITASLAEHKSAHM--QTGQNSIPALAQV-------------------------------------------------AAIAETDDSADS-EVIDSHKRREILSRRPSYRKILNELSSDVPGIPKIEEERSEEEGTPPNIATMAVPTSIYQTSTGQYI---------------------------------------------------FFVP---VVVQ-EETDLAPSHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD-
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.