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NHE3 human	MWGLGARGPDRGLLLAL--ALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRyRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNyLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAIsYVAEGERRGsLAFIRSPstDNVVNVDFT-PRSSTVEASVSYLLRENVsAVCLDMQsLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELtPTEDEKQDREIFHRTMRKRLEsFKSTKLGLNQNKKAAKL-YkRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYD--EEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYsPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
NHE3 mouse	MWHR-ALGPGWKLLLAL--ALTSLQGARGAEEEP----SSDGSFQVVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSIVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVNPDIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSkVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGsLAFIRSPSTDNMVNVDFNTPRPSTVEASVSYFLRENVsAVCLDMQSLEQRRRsIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKL-YKRERAQKRRNSSIPNGKLPMENLAHNYTIKEKDLELSEHEEATNYE---EISGGIEFLASVTQDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNsPsNFRRLTPFRLsNKsVDsFLQADGHEEQLQPAAPESTHM
NHE3 rat	MWHP-ALGPGWKPLLALAVAVTSLRGVRGIEEEP----NSGGSFQIVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGsLAFIRSPsTDNMVNVDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRsIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELtPNEDEKQDKEIFHRTMRKRLEsFKSAKLGINQNKKAAKL-YKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELsEPEEATNYE---EISGGIEFLASVTKDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNsPsNFRRLTPFRLsNksVDsFLQADGPEEQLQPAsPESTHM
NHE3 rabbit	MSGRGGCGPCWGLLLALVLALGALPWTQGAEQE---HHDEIQGFQIVTFKWHHVQDPYIIALWVLVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVLAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFSNLGSILLYAVVGTVWNAATTGLSLYGVFLSGIMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFQSFVTLGGDKVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRVIEPGFVFIISYLSYLTSEMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPLIWTWNTAFVLLTLLFVSVFRAIGVVLQTWLLNRYRMVQLELIDQVVMSYGGLRGAVAFALVALLDGNKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWANFDRRFLsKLLMRQsAQKsRDRILNVFHELNLKDAISYVTEGERRGsLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYLLRESASAVCLDMQSLEQRRRsVRDAEDVITHHTLQQYLYKPRQEYKHLYSRHVLSPSEDEKQDKEIFHRTMRKRLEsFKSAKLGLGQSKKATKHKRERERAQKRRNSSVPNGKLPLDSPAYGLTLKERELELsDPEEAPDYYEAEKMSGGIEFLASVTKDTTSDSPAGIDNPVFSPDEDLAPSLLARVPPWLSPGEAVVPSQRARVQIPYSPGNFRRLAPFRLSNKSVDSFLLAEDGAEH-----PESTHM
	*::..:.**.:::****..*:::*..:.*:*.*:  ...:.::**:***:*:******:****:********:*********:******************:*************:***********************:***:******:**:*****************:**:*:************:*******************************************:***:****:*************************:****************:*******:***************:************************************:**************:*.*************:*:**:**********:**********.*****:**********:***:***:.************:***************************:***:*********************************::***:***::***:*************************:******************:*****.:**:*********:***::****************:**:**::***********************:*:*.******:****************:***::*:***:*: ::***********:******::::*.:.*:**::****:.**:::*.  .::***********:*::***:************:*::*:*:*:********:********:***:**::*:**:*****:*******:*::.:*...::.******
Consensus	MWGRGALGPGWGLLLAL--ALGSLAGARGAEEEP---HNEDGGFQIVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVNPDIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAFALVVLLDEKKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKL-YKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSDPEEAPNYE--EEISGGIEFLASVTKDTASDSGAGIDNPVFSPDEDLDPSILARVPPWLSPGETVVPSQRARVQIPNSPGNFRRLTPFRLSNKSVDSFLQADGPEEQLQPAAPESTHM