Multiple Sequence Alignment:
CASP8 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570    )
           |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |    
CASP8 human -----------------------------------------------------------MDFSRNLYDIGEQLDsEDLASLkFLSLDYIPQRkQEPIkDALMLFQRLQEKRMLEESNLSFLkELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYR--------------------------------VMLYQISEEVsRSELRSFkFLLQEEISkCKLDDDMNLLDIFIEMEkRVILGEGk
LDILkRVCAQINkSLLkIINDyEEFSkERSSSLEGsPDEFSN--GEELCGVMTIsDsPREQDSEsQTLDkVYQMkSKPRGyCLIINNHNFAKAREKVPkLHSIRDRNGtHLDAGALTTtFEELHFEIKPHDDCTVEQIYEILKIYQLMDHsNMDCFICCILSHGDKGIIYGTDGQEAPIyELTSQFTGLkCPsLAGkPkVFFIQACQGDNYQKGIPVEtDsE--EQPyLEMDLSsPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNyEVSNKDDKKNMGkQMPQPTFTLRKkLVFPSD
CASP8 iso2 human
CASP8 iso4 human -----------------------------------------------------------MDFSRNLyDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEF---------------Sk--GEELCGVMTISDsPREQDSESQTLDKVyQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIyELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE--EQPyLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNyEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
CASP8 iso5 human -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYR--------------------------------VMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSN--DFGQSL-------PNEkQTSG-ILS-----DHQQSQFCKSTGESAQTSQH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
CASP8 iso6 human -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYR--------------------------------VMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEF---------------Sk--DFGQSL-------PNEkQTSG-ILS-----DHQQSQFCKSTGESAQTSQH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
CASP8 iso9 human MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADyILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYR--------------------------------VMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGkLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSN--GEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE--EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
CASP8 mouse -----------------------------------------------------------MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYR--------------------------------VMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMsLEGREELPPsVLDEMSLKMAELCDsPREQDSESRTSDkVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGtDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVP--DEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP-
CASP8 rat -----------------------------------------------------------MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSFLKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAYR--------------------------------VMLFKLSEDMDKEDLKSFKFLLITEIPKCKLQDNSSLLDIFVEMEKRTILAENNLVTLKSICFRVNRSLLGRIDDYERSSTERRMstEGGEELPVSVLDEVTIKMQDMWDSPGEQESESLNSDNVYQMKSKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEALSKTFKELHFEIVSFSDCTASQIHEVLVSYQSKDHKGKDCFICCILSHGDKGIVYGTDGKEASIYELTSYFTGSKCPSLAGKPKIFFIQACQGNNFQKAVPVPDETGLE-QEHVLEEDSSSYKNYIPDEADFLLGMATVKNCVSYRDPTRGTWYIQSLCQSLRERCPRGEDILSILTGVNYDVSNKDNPRNMGKQMPQPIFTLRKKLFFPPN
                                                             ***:::**:*:*:*::*:**:****:**:**::***:*:*:::**:**:*::****:**********:*:*:***:::*::::***:***:::::**:*:**                                ***:::**::::::*:******::**:****:*:::**:**:*****::*:*::*::**::*:::*:***::*:***:::.::..:.::.....:.  ::.........::*:*:::::.:::.:::::::::::*:::::::::::::....:....::.::..:..::..::.::::::....:::...:.:.:..::..::...::::::::::::::..:::::.::.::.:::.:::.:::::.::::.::::::::.:.:::.:......  .:.......::....:::::::::::::::.::::::.:..:::::::::::::::::.:.:::.:::.:::.:::::...:.:::::::.:::::::.::..
Consensus -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYR--------------------------------VMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSN--DEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE--EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.