Multiple Sequence Alignment:
Ikaros Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540  )
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Ikaros human MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVA--------------------SNVkVEtQsDEENGRACEMNGEECAEDLrMLDAsGEkMNGsHRDQGSSALsGVGGIRLPNGkLKCDICGIICIGPNVLMVHKRSHtGERPFQCNQCGASFTQkGNLLRHIkLHsGEkPFkCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRssLEEHkERCHNYLESMGLPGTLYPVIkEETNHSEMAEDLCkIGsERsLVLDRLAsNVAkRKSSMPQkFLGDkGLsDtPyDssAsyEkENEMMKSHVMDQAINNAINyLGAESLRPLVQtPPGGSEVVPVIsPMyQLHKPLAEGtPRsNHsAQDsAVENLLLLskAkLVPSEREAsPsNsCQDstDTEsNNEEQRsGLIyLtNHIAPHARNGLsLkEEHRAyDLLRAAsENsQDALRVVSTSGEQMkVYKCEHCRVLFLDHVMYTIHMGC---HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
Ikaros iso2 human MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRV-----------------------------------------------------------------------------------------------------------VGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGC---HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
Ikaros iso3 human MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVA--------------------SNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHS---------------------------------------------------------------------------------------GDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGC---HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
Ikaros iso7 human MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVA--------------------SNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHs------------------------------------------VIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGC---HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
Ikaros mouse MDVDEGQDMSQVsGKESPPVSDtPDEGDEPMPVPEDLSTTSGAQQNSKSDRGMG--------------------SNVkVETQsDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGsSALSGVGGIRLPNGKLKCDICGIVCIGPNVLMVHKRSHt-ERPFQCNQCGASFTQKGNLLRHIKLHsGEKPFKCHLCNYACRRRDALTGHLRTHsVGKPHKCGYCGRSYKQRssLEEHKERCHNYLESMGLPG-VCPVIkEETNHNEMAEDLCKIGAERSLVLDRLAsNVAKRKSSMPQKFLGDKCLSDMPYDsAN-YE-KEDMMTSHVMDQAINNAINyLGAEsLRPLVQtPPGssEVVPVIssMyQLHKPPsDGPPRsNHsAQD-AVDNLLLLsKAKSVSSEREAsPsNsCQDstDtESNAEEQRsGLIYLTNHINPHARNGLALKEEQRAYEVLRAAsENsQDAFRVVSTSGEQLKVYKCEHCRVLFLDHVMYTIHMGCHGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRYHLS
Ikaros iso9 mouse MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTTSGAQQNSKSDRGMVAYGADGFRDFHAIIPKSFsPSNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIVCIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPG-MYPVIKEETNHNEMAEDLCKIGAERSLVLDRLASNVAKRKSSMPQKFLGDKCLSDMPYDSAN-YE-KEDMMTSHVMDQAINNAINYLGAESLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQD-AVDNLLLLSKAKSVSSEREASPSNSCQDSTDTESNAEEQRSGLIYLTNHINPHARNGLALKEEQRAYEVLRAASENSQDAFRVVSTSGEQLKVYKCEHCRVLFLDHVMYTIHMGC---HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRYHLS
  **:*****************************:*********:**:*****:..                    ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::*******************************************************::::::::::::::::::::::::::::::::::::::...:::::::::.::::::::::::::::::::::::::::::::::::***:***:****:::**::::**:*****************************:********:*******:::*:*********:**:*********:*:********************:**************:*******:****:***::***********:*********:************************   ********************************:*:*
Consensus MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVA--------------------SNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPG-LYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGC---HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.